UniProtKB - P75826 (LYSO_ECOLI)
Protein
Lysine exporter LysO
Gene
lysO
Organism
Escherichia coli (strain K12)
Status
Functioni
Mediates export of lysine.1 Publication
GO - Molecular functioni
- L-lysine efflux transmembrane transporter activity Source: EcoCyc
GO - Biological processi
- L-lysine transmembrane transport Source: EcoCyc
Keywordsi
Biological process | Amino-acid transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:G6458-MONOMER MetaCyc:G6458-MONOMER |
Protein family/group databases
TCDBi | 2.A.124.1.1, the lysine exporter (lyso) family |
Names & Taxonomyi
Protein namesi | Recommended name: Lysine exporter LysOCuratedAlternative name(s): Lys outward permease1 Publication |
Gene namesi | Name:lysO1 Publication Synonyms:ybjE Ordered Locus Names:b0874, JW0858 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane Curated; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- integral component of plasma membrane Source: EcoCyc
- plasma membrane Source: EcoCyc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1 – 21 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 31 – 51 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 58 – 78 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 109 – 129 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 131 – 151 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 169 – 189 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 207 – 227 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 277 – 297 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Null mutant is hypersensitive to the lysine antimetabolite thialysine.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000168737 | 1 – 299 | Lysine exporter LysOAdd BLAST | 299 |
Proteomic databases
PaxDbi | P75826 |
PRIDEi | P75826 |
Expressioni
Inductioni
Repressed by arginine, via the ArgR repressor.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4259999, 17 interactors 851475, 1 interactor |
DIPi | DIP-11447N |
IntActi | P75826, 2 interactors |
STRINGi | 511145.b0874 |
Family & Domainsi
Sequence similaritiesi
Belongs to the LysO family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2431, Bacteria |
HOGENOMi | CLU_045681_1_0_6 |
InParanoidi | P75826 |
Family and domain databases
InterProi | View protein in InterPro IPR005642, LysO |
PANTHERi | PTHR35804, PTHR35804, 1 hit |
Pfami | View protein in Pfam PF03956, Lys_export, 1 hit |
i Sequence
Sequence statusi: Complete.
P75826-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFSGLLIILV PLIVGYLIPL RQQAALKVIN QLLSWMVYLI LFFMGISLAF
60 70 80 90 100
LDNLASNLLA ILHYSAVSIT VILLCNIAAL MWLERGLPWR NHHQQEKLPS
110 120 130 140 150
RIAMALESLK LCGVVVIGFA IGLSGLAFLQ HATEASEYTL ILLLFLVGIQ
160 170 180 190 200
LRNNGMTLKQ IVLNRRGMIV AVVVVVSSLI GGLINAFILD LPINTALAMA
210 220 230 240 250
SGFGWYSLSG ILLTESFGPV IGSAAFFNDL ARELIAIMLI PGLIRRSRST
260 270 280 290
ALGLCGATSM DFTLPVLQRT GGLDMVPAAI VHGFILSLLV PILIAFFSA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC73961.2 AP009048 Genomic DNA Translation: BAA35588.1 |
RefSeqi | NP_415395.2, NC_000913.3 WP_000491142.1, NZ_STEB01000019.1 |
Genome annotation databases
EnsemblBacteriai | AAC73961; AAC73961; b0874 BAA35588; BAA35588; BAA35588 |
GeneIDi | 58388675 947142 |
KEGGi | ecj:JW0858 eco:b0874 |
PATRICi | fig|1411691.4.peg.1403 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC73961.2 AP009048 Genomic DNA Translation: BAA35588.1 |
RefSeqi | NP_415395.2, NC_000913.3 WP_000491142.1, NZ_STEB01000019.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4259999, 17 interactors 851475, 1 interactor |
DIPi | DIP-11447N |
IntActi | P75826, 2 interactors |
STRINGi | 511145.b0874 |
Protein family/group databases
TCDBi | 2.A.124.1.1, the lysine exporter (lyso) family |
Proteomic databases
PaxDbi | P75826 |
PRIDEi | P75826 |
Genome annotation databases
EnsemblBacteriai | AAC73961; AAC73961; b0874 BAA35588; BAA35588; BAA35588 |
GeneIDi | 58388675 947142 |
KEGGi | ecj:JW0858 eco:b0874 |
PATRICi | fig|1411691.4.peg.1403 |
Organism-specific databases
EchoBASEi | EB3200 |
Phylogenomic databases
eggNOGi | COG2431, Bacteria |
HOGENOMi | CLU_045681_1_0_6 |
InParanoidi | P75826 |
Enzyme and pathway databases
BioCyci | EcoCyc:G6458-MONOMER MetaCyc:G6458-MONOMER |
Miscellaneous databases
PROi | PR:P75826 |
Family and domain databases
InterProi | View protein in InterPro IPR005642, LysO |
PANTHERi | PTHR35804, PTHR35804, 1 hit |
Pfami | View protein in Pfam PF03956, Lys_export, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LYSO_ECOLI | |
Accessioni | P75826Primary (citable) accession number: P75826 Secondary accession number(s): Q9R2W1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | April 27, 2001 | |
Last modified: | April 7, 2021 | |
This is version 136 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families