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UniProtKB - P75811 (RCDA_ECOLI)
Protein
HTH-type transcriptional regulator RcdA
Gene
rcdA
Organism
Escherichia coli (strain K12)
Status
Functioni
Regulates the expression of a number of genes involved in biofilm formation and stress response. Target genes include six stress-response transcriptional regulators: csgD, which is a master regulator of biofilm formation, appY, sxy, ycgF, fimB and rcdA itself. This indicates that a large number of genes must be regulated indirectly via these transcriptional regulators. Acts by binding to the upstream region of its target genes.
1 PublicationMiscellaneous
Has a strong cooperative DNA-binding mode, leading to aggregation of RcdA-DNA complexes.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 30 – 49 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 20 |
GO - Molecular functioni
- DNA binding Source: EcoCyc
- DNA-binding transcription factor activity Source: EcoliWiki
GO - Biological processi
- positive regulation of transcription, DNA-templated Source: EcoliWiki
- transcription, DNA-templated Source: EcoCyc
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | EcoCyc:G6444-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: HTH-type transcriptional regulator RcdAAlternative name(s): Regulator of csgD |
Gene namesi | Name:rcdA Synonyms:ybjK Ordered Locus Names:b0846, JW5114 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070634 | 1 – 178 | HTH-type transcriptional regulator RcdAAdd BLAST | 178 |
Proteomic databases
PaxDbi | P75811 |
PRIDEi | P75811 |
Expressioni
Inductioni
Autoregulated.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4262832, 5 interactors |
STRINGi | 511145.b0846 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P75811 |
SMRi | P75811 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 67 | HTH tetR-typePROSITE-ProRule annotationAdd BLAST | 61 |
Phylogenomic databases
eggNOGi | COG3226, Bacteria |
HOGENOMi | CLU_069356_21_2_6 |
InParanoidi | P75811 |
OMAi | SMTYHFD |
PhylomeDBi | P75811 |
Family and domain databases
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001647, HTH_TetR IPR036271, Tet_transcr_reg_TetR-rel_C_sf |
Pfami | View protein in Pfam PF00440, TetR_N, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF48498, SSF48498, 1 hit |
PROSITEi | View protein in PROSITE PS50977, HTH_TETR_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P75811-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRRANDPQRR EKIIQATLEA VKLYGIHAVT HRKIATLAGV PLGSMTYYFS
60 70 80 90 100
GIDELLLEAF SSFTEIMSRQ YQAFFSDVSD APGACQAITD MIYSSQVATP
110 120 130 140 150
DNMELMYQLY ALASRKPLLK TVMQNWMQRS QQTLEQWFEP GTARALDAFI
160 170
EGMTLHFVTD RKPLSREEIL RMVERVAG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC73933.1 AP009048 Genomic DNA Translation: BAA35550.2 |
PIRi | F64822 |
RefSeqi | NP_415367.1, NC_000913.3 WP_001295289.1, NZ_SSZK01000002.1 |
Genome annotation databases
EnsemblBacteriai | AAC73933; AAC73933; b0846 BAA35550; BAA35550; BAA35550 |
GeneIDi | 945473 |
KEGGi | ecj:JW5114 eco:b0846 |
PATRICi | fig|511145.12.peg.874 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC73933.1 AP009048 Genomic DNA Translation: BAA35550.2 |
PIRi | F64822 |
RefSeqi | NP_415367.1, NC_000913.3 WP_001295289.1, NZ_SSZK01000002.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5X5I | X-ray | 2.55 | A/B/C/D/E/F/G/H | 1-178 | [»] | |
7ACL | X-ray | 2.05 | A/B | 1-178 | [»] | |
7ACM | X-ray | 1.76 | A/B | 1-178 | [»] | |
7ACO | X-ray | 1.80 | A/B | 1-178 | [»] | |
AlphaFoldDBi | P75811 | |||||
SMRi | P75811 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4262832, 5 interactors |
STRINGi | 511145.b0846 |
Proteomic databases
PaxDbi | P75811 |
PRIDEi | P75811 |
Genome annotation databases
EnsemblBacteriai | AAC73933; AAC73933; b0846 BAA35550; BAA35550; BAA35550 |
GeneIDi | 945473 |
KEGGi | ecj:JW5114 eco:b0846 |
PATRICi | fig|511145.12.peg.874 |
Organism-specific databases
EchoBASEi | EB3444 |
Phylogenomic databases
eggNOGi | COG3226, Bacteria |
HOGENOMi | CLU_069356_21_2_6 |
InParanoidi | P75811 |
OMAi | SMTYHFD |
PhylomeDBi | P75811 |
Enzyme and pathway databases
BioCyci | EcoCyc:G6444-MONOMER |
Miscellaneous databases
PROi | PR:P75811 |
Family and domain databases
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001647, HTH_TetR IPR036271, Tet_transcr_reg_TetR-rel_C_sf |
Pfami | View protein in Pfam PF00440, TetR_N, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF48498, SSF48498, 1 hit |
PROSITEi | View protein in PROSITE PS50977, HTH_TETR_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RCDA_ECOLI | |
Accessioni | P75811Primary (citable) accession number: P75811 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 27, 2002 |
Last sequence update: | March 27, 2002 | |
Last modified: | May 25, 2022 | |
This is version 149 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references