UniProtKB - P75804 (YLII_ECOLI)
Protein
Aldose sugar dehydrogenase YliI
Gene
yliI
Organism
Escherichia coli (strain K12)
Status
Functioni
Aldose sugar dehydrogenase with broad substrate specificity. The physiological substrate is unknown. Can oxidize glucose to gluconolactone. Can also utilize D-arabinose, L-arabinose and 2-deoxy-glucose. Has higher activity towards oligomeric sugars, such as maltose, maltotriose or cellobiose. It may function to input sugar-derived electrons into the respiratory network.1 Publication
Cofactori
Protein has several cofactor binding sites:- Ca2+1 PublicationNote: Binds 2 calcium ions per monomer.1 Publication
- pyrroloquinoline quinone
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 82 | PQQ1 Publication | 1 | |
Active sitei | 147 | Proton acceptorBy similarity | 1 | |
Metal bindingi | 240 | Calcium1 Publication | 1 | |
Metal bindingi | 250 | Calcium; via carbonyl oxygen1 Publication | 1 | |
Binding sitei | 261 | PQQ1 Publication | 1 |
GO - Molecular functioni
- calcium ion binding Source: EcoCyc
- oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor Source: EcoCyc
- pyrroloquinoline quinone binding Source: EcoCyc
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Calcium, Metal-binding, PQQ |
Enzyme and pathway databases
BioCyci | EcoCyc:G6437-MONOMER MetaCyc:G6437-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Aldose sugar dehydrogenase YliI1 Publication (EC:1.1.5.-)Short name: Asd1 Publication Alternative name(s): Soluble aldose sugar dehydrogenase YliI |
Gene namesi | Name:yliI Ordered Locus Names:b0837, JW0821 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cell outer membrane 1 Publication
GO - Cellular componenti
- cell outer membrane Source: UniProtKB-SubCell
- outer membrane-bounded periplasmic space Source: EcoCyc
Keywords - Cellular componenti
Cell outer membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000025584 | 21 – 371 | Aldose sugar dehydrogenase YliIAdd BLAST | 351 |
Proteomic databases
jPOSTi | P75804 |
PaxDbi | P75804 |
PRIDEi | P75804 |
Interactioni
Subunit structurei
Monomer.
1 PublicationProtein-protein interaction databases
BioGRIDi | 4261449, 280 interactors |
IntActi | P75804, 2 interactors |
STRINGi | 511145.b0837 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P75804 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P75804 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 214 – 215 | PQQ | 2 | |
Regioni | 312 – 314 | PQQ | 3 | |
Regioni | 341 – 343 | PQQ | 3 |
Sequence similaritiesi
Belongs to the PQQ oxidoreductase GdhB family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | COG2133, Bacteria |
HOGENOMi | CLU_012253_1_1_6 |
InParanoidi | P75804 |
PhylomeDBi | P75804 |
Family and domain databases
Gene3Di | 2.120.10.30, 1 hit |
InterProi | View protein in InterPro IPR011042, 6-blade_b-propeller_TolB-like IPR012938, Glc/Sorbosone_DH IPR011041, Quinoprot_gluc/sorb_DH |
Pfami | View protein in Pfam PF07995, GSDH, 1 hit |
SUPFAMi | SSF50952, SSF50952, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P75804-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHRQSFFLVP LICLSSALWA APATVNVEVL QDKLDHPWAL AFLPDNHGML
60 70 80 90 100
ITLRGGELRH WQAGKGLSAP LSGVPDVWAH GQGGLLDVVL APDFAQSRRI
110 120 130 140 150
WLSYSEVGDD GKAGTAVGYG RLSDDLSKVT DFRTVFRQMP KLSTGNHFGG
160 170 180 190 200
RLVFDGKGYL FIALGENNQR PTAQDLDKLQ GKLVRLTDQG EIPDDNPFIK
210 220 230 240 250
ESGARAEIWS YGIRNPQGMA MNPWSNALWL NEHGPRGGDE INIPQKGKNY
260 270 280 290 300
GWPLATWGIN YSGFKIPEAK GEIVAGTEQP VFYWKDSPAV SGMAFYNSDK
310 320 330 340 350
FPQWQQKLFI GALKDKDVIV MSVNGDKVTE DGRILTDRGQ RIRDVRTGPD
360 370
GYLYVLTDES SGELLKVSPR N
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC73924.1 AP009048 Genomic DNA Translation: BAA35540.1 |
PIRi | E64821 |
RefSeqi | NP_415358.1, NC_000913.3 WP_000555031.1, NZ_SSZK01000002.1 |
Genome annotation databases
EnsemblBacteriai | AAC73924; AAC73924; b0837 BAA35540; BAA35540; BAA35540 |
GeneIDi | 57729565 945467 |
KEGGi | ecj:JW0821 eco:b0837 |
PATRICi | fig|1411691.4.peg.1441 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC73924.1 AP009048 Genomic DNA Translation: BAA35540.1 |
PIRi | E64821 |
RefSeqi | NP_415358.1, NC_000913.3 WP_000555031.1, NZ_SSZK01000002.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2G8S | X-ray | 1.50 | A/B | 21-370 | [»] | |
SMRi | P75804 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4261449, 280 interactors |
IntActi | P75804, 2 interactors |
STRINGi | 511145.b0837 |
Proteomic databases
jPOSTi | P75804 |
PaxDbi | P75804 |
PRIDEi | P75804 |
Genome annotation databases
EnsemblBacteriai | AAC73924; AAC73924; b0837 BAA35540; BAA35540; BAA35540 |
GeneIDi | 57729565 945467 |
KEGGi | ecj:JW0821 eco:b0837 |
PATRICi | fig|1411691.4.peg.1441 |
Organism-specific databases
EchoBASEi | EB3253 |
Phylogenomic databases
eggNOGi | COG2133, Bacteria |
HOGENOMi | CLU_012253_1_1_6 |
InParanoidi | P75804 |
PhylomeDBi | P75804 |
Enzyme and pathway databases
BioCyci | EcoCyc:G6437-MONOMER MetaCyc:G6437-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P75804 |
PROi | PR:P75804 |
Family and domain databases
Gene3Di | 2.120.10.30, 1 hit |
InterProi | View protein in InterPro IPR011042, 6-blade_b-propeller_TolB-like IPR012938, Glc/Sorbosone_DH IPR011041, Quinoprot_gluc/sorb_DH |
Pfami | View protein in Pfam PF07995, GSDH, 1 hit |
SUPFAMi | SSF50952, SSF50952, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | YLII_ECOLI | |
Accessioni | P75804Primary (citable) accession number: P75804 Secondary accession number(s): Q9R7R6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | February 1, 1997 | |
Last modified: | February 10, 2021 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families