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Protein

Probable cyclic di-GMP phosphodiesterase PdeI

Gene

pdeI

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG (By similarity). Overexpression reduces biofilm formation. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria (PubMed:19460094).By similarity1 Publication

Catalytic activityi

Cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine.By similarity

GO - Molecular functioni

  • cyclic-guanylate-specific phosphodiesterase activity Source: EcoCyc

Keywordsi

Molecular functionHydrolase
Ligandc-di-GMP

Enzyme and pathway databases

BioCyciEcoCyc:G6433-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cyclic di-GMP phosphodiesterase PdeICurated (EC:3.1.4.52By similarity)
Gene namesi
Name:pdeI1 Publication
Synonyms:yliE
Ordered Locus Names:b0833, JW0817
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13476 yliE

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Transmembranei286 – 306HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Cells lacking this gene have a weak reduction in swarm size.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001687291 – 782Probable cyclic di-GMP phosphodiesterase PdeIAdd BLAST782

Proteomic databases

PaxDbiP75800
PRIDEiP75800

Interactioni

Protein-protein interaction databases

BioGridi4259986, 11 interactors
STRINGi316385.ECDH10B_0902

Structurei

3D structure databases

ProteinModelPortaliP75800
SMRiP75800
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini527 – 781EALPROSITE-ProRule annotationAdd BLAST255

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZU Bacteria
ENOG410XNMH LUCA
HOGENOMiHOG000118172
OMAiEFRHFSE
PhylomeDBiP75800

Family and domain databases

CDDicd01948 EAL, 1 hit
Gene3Di3.20.20.450, 1 hit
InterProiView protein in InterPro
IPR033418 CHASE9
IPR001633 EAL_dom
IPR035919 EAL_sf
PfamiView protein in Pfam
PF17153 CHASE9, 1 hit
PF00563 EAL, 1 hit
SMARTiView protein in SMART
SM00052 EAL, 1 hit
SUPFAMiSSF141868 SSF141868, 1 hit
PROSITEiView protein in PROSITE
PS50883 EAL, 1 hit

Sequencei

Sequence statusi: Complete.

P75800-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSLYEKIKI RLIILFLLAA LSFIGLFFII NYQLVSERAV KRADSRFELI
60 70 80 90 100
QKNVGYFFKD IERSALTLKD SLYLLKNTEE IQRAVILKME MMPFLDSVGL
110 120 130 140 150
VLDDNKYYLF SRRANDKIVV YHQEQVNGPL VDESGRVIFA DFNPSKRPWS
160 170 180 190 200
VASDDSNNSW NPAYNCFDRP GKKCISFTLH INGKDHDLLA VDKIHVDLNW
210 220 230 240 250
RYLNEYLDQI SANDEVLFLK QGHEIIAKNQ LAREKLIIYN SEGNYNIIDS
260 270 280 290 300
VDTEYIEKTS AVPNNALFEI YFYYPGGNLL NASDKLFYLP FAFIIIVLLV
310 320 330 340 350
VYLMTTRVFR RQFSEMTELV NTLAFLPDST DQIEALKIRE GDAKEIISIK
360 370 380 390 400
NSIAEMKDAE IERSNKLLSL ISYDQESGFI KNMAIIESNN NQYLAVGIIK
410 420 430 440 450
LCGLEAVEAV FGVDERNKIV RKLCQRIAEK YAQCCDIVTF NADLYLLLCR
460 470 480 490 500
ENVQTFTRKI AMVNDFDSSF GYRNLRIHKS AICEPLQGEN AWSYAEKLKL
510 520 530 540 550
AISSIRDHMF SEFIFCDDAK LNEIEENIWI ARNIRHAMEI GELFLVYQPI
560 570 580 590 600
VDINTRAILG AEALCRWVSA ERGIISPLKF ITIAEDIGFI NELGYQIIKT
610 620 630 640 650
AMGEFRHFSQ RASLKDDFLL HINVSPWQLN EPHFHERFTT IMKENGLKAN
660 670 680 690 700
SLCVEITETV IERINEHFYL NIEQLRKQGV RISIDDFGTG LSNLKRFYEI
710 720 730 740 750
NPDSIKVDSQ FTGDIFGTAG KIVRIIFDLA RYNRIPVIAE GVESEDVARE
760 770 780
LIKLGCVQAQ GYLYQKPMPF SAWDKSGKLV KE
Length:782
Mass (Da):90,049
Last modified:February 1, 1997 - v1
Checksum:i608DFB0068611DFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC73920.1
AP009048 Genomic DNA Translation: BAA35528.1
PIRiA64821
RefSeqiNP_415354.1, NC_000913.3
WP_001360263.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73920; AAC73920; b0833
BAA35528; BAA35528; BAA35528
GeneIDi945462
KEGGiecj:JW0817
eco:b0833
PATRICifig|1411691.4.peg.1445

Similar proteinsi

Entry informationi

Entry nameiPDEI_ECOLI
AccessioniPrimary (citable) accession number: P75800
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 1, 1997
Last modified: April 25, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

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