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UniProtKB - P75798 (GSIC_ECOLI)
Protein
Glutathione transport system permease protein GsiC
Gene
gsiC
Organism
Escherichia coli (strain K12)
Status
Functioni
Part of the ABC transporter complex GsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane.
1 PublicationGO - Molecular functioni
- glutathione transmembrane transporter activity Source: GO_Central
GO - Biological processi
- glutathione transmembrane transport Source: GO_Central
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:YLIC-MONOMER |
BRENDAi | 7.4.2.10, 2026 |
Protein family/group databases
TCDBi | 3.A.1.5.11, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Glutathione transport system permease protein GsiCCurated |
Gene namesi | Name:gsiC1 Publication Synonyms:yliC Ordered Locus Names:b0831, JW0815 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing Source: ComplexPortal
- integral component of plasma membrane Source: EcoCyc
- plasma membrane Source: EcoCyc
Other locations
- membrane Source: ComplexPortal
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 8 | CytoplasmicCurated | 8 | |
Transmembranei | 9 – 29 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 30 – 102 | PeriplasmicCuratedAdd BLAST | 73 | |
Transmembranei | 103 – 123 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 124 – 134 | CytoplasmicCuratedAdd BLAST | 11 | |
Transmembranei | 135 – 155 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 156 – 168 | PeriplasmicCuratedAdd BLAST | 13 | |
Transmembranei | 169 – 189 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 190 – 228 | CytoplasmicCuratedAdd BLAST | 39 | |
Transmembranei | 229 – 249 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 250 – 277 | PeriplasmicCuratedAdd BLAST | 28 | |
Transmembranei | 278 – 298 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 299 – 306 | Cytoplasmic1 Publication | 8 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000060261 | 1 – 306 | Glutathione transport system permease protein GsiCAdd BLAST | 306 |
Proteomic databases
PaxDbi | P75798 |
PRIDEi | P75798 |
Interactioni
Subunit structurei
The complex is composed of two ATP-binding proteins (GsiA), two transmembrane proteins (GsiC and GsiD) and a solute-binding protein (GsiB) (Probable). In the presence of glutathione, interacts with the glutathione-binding protein GsiB (PubMed:30515393).
1 Publication1 PublicationProtein-protein interaction databases
BioGRIDi | 4259983, 14 interactors |
ComplexPortali | CPX-4325, Glutathione ABC transporter complex |
IntActi | P75798, 2 interactors |
STRINGi | 511145.b0831 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 95 – 292 | ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST | 198 |
Sequence similaritiesi
Belongs to the binding-protein-dependent transport system permease family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0601, Bacteria |
HOGENOMi | CLU_036879_0_0_6 |
InParanoidi | P75798 |
OMAi | MQEDYMR |
PhylomeDBi | P75798 |
Family and domain databases
CDDi | cd06261, TM_PBP2, 1 hit |
Gene3Di | 1.10.3720.10, 1 hit |
InterProi | View protein in InterPro IPR045621, BPD_transp_1_N IPR000515, MetI-like IPR035906, MetI-like_sf |
Pfami | View protein in Pfam PF00528, BPD_transp_1, 1 hit PF19300, BPD_transp_1_N, 1 hit |
SUPFAMi | SSF161098, SSF161098, 1 hit |
PROSITEi | View protein in PROSITE PS50928, ABC_TM1, 1 hit |
i Sequence
Sequence statusi: Complete.
P75798-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLNYVIKRLL GLIPTLFIVS VLVFLFVHML PGDPARLIAG PEADAQVIEL
60 70 80 90 100
VRQQLGLDQP LYHQFWHYIS NAVQGDFGLS MVSRRPVADE IASRFMPTLW
110 120 130 140 150
LTITSMVWAV IFGMAAGIIA AVWRNRWPDR LSMTIAVSGI SFPAFALGML
160 170 180 190 200
LIQVFSVELG WLPTVGADSW QHYILPSLTL GAAVAAVMAR FTRASFVDVL
210 220 230 240 250
SEDYMRTARA KGVSETWVVL KHGLRNAMIP VVTMMGLQFG FLLGGSIVVE
260 270 280 290 300
KVFNWPGLGR LLVDSVEMRD YPVIQAEILL FSLEFILINL VVDVLYAAIN
PAIRYK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC73918.1 AP009048 Genomic DNA Translation: BAA35526.1 |
PIRi | G64820 |
RefSeqi | NP_415352.1, NC_000913.3 WP_000936043.1, NZ_STEB01000019.1 |
Genome annotation databases
EnsemblBacteriai | AAC73918; AAC73918; b0831 BAA35526; BAA35526; BAA35526 |
GeneIDi | 66670895 945460 |
KEGGi | ecj:JW0815 eco:b0831 |
PATRICi | fig|1411691.4.peg.1447 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC73918.1 AP009048 Genomic DNA Translation: BAA35526.1 |
PIRi | G64820 |
RefSeqi | NP_415352.1, NC_000913.3 WP_000936043.1, NZ_STEB01000019.1 |
3D structure databases
AlphaFoldDBi | P75798 |
SMRi | P75798 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4259983, 14 interactors |
ComplexPortali | CPX-4325, Glutathione ABC transporter complex |
IntActi | P75798, 2 interactors |
STRINGi | 511145.b0831 |
Protein family/group databases
TCDBi | 3.A.1.5.11, the atp-binding cassette (abc) superfamily |
Proteomic databases
PaxDbi | P75798 |
PRIDEi | P75798 |
Genome annotation databases
EnsemblBacteriai | AAC73918; AAC73918; b0831 BAA35526; BAA35526; BAA35526 |
GeneIDi | 66670895 945460 |
KEGGi | ecj:JW0815 eco:b0831 |
PATRICi | fig|1411691.4.peg.1447 |
Organism-specific databases
EchoBASEi | EB3247 |
Phylogenomic databases
eggNOGi | COG0601, Bacteria |
HOGENOMi | CLU_036879_0_0_6 |
InParanoidi | P75798 |
OMAi | MQEDYMR |
PhylomeDBi | P75798 |
Enzyme and pathway databases
BioCyci | EcoCyc:YLIC-MONOMER |
BRENDAi | 7.4.2.10, 2026 |
Miscellaneous databases
PROi | PR:P75798 |
Family and domain databases
CDDi | cd06261, TM_PBP2, 1 hit |
Gene3Di | 1.10.3720.10, 1 hit |
InterProi | View protein in InterPro IPR045621, BPD_transp_1_N IPR000515, MetI-like IPR035906, MetI-like_sf |
Pfami | View protein in Pfam PF00528, BPD_transp_1, 1 hit PF19300, BPD_transp_1_N, 1 hit |
SUPFAMi | SSF161098, SSF161098, 1 hit |
PROSITEi | View protein in PROSITE PS50928, ABC_TM1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GSIC_ECOLI | |
Accessioni | P75798Primary (citable) accession number: P75798 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | February 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families