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Protein

Putative formate acetyltransferase 3

Gene

ybiW

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + formate = CoA + pyruvate.

Pathwayi: pyruvate fermentation

This protein is involved in step 1 of the subpathway that synthesizes formate from pyruvate.
Proteins known to be involved in this subpathway in this organism are:
  1. Formate acetyltransferase 1 (pflB), Putative formate acetyltransferase 3 (ybiW), Formate acetyltransferase 2 (pflD)
This subpathway is part of the pathway pyruvate fermentation, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes formate from pyruvate, the pathway pyruvate fermentation and in Fermentation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BioCyciEcoCyc:G6426-MONOMER
UniPathwayi
UPA00920;UER00891

Names & Taxonomyi

Protein namesi
Recommended name:
Putative formate acetyltransferase 3 (EC:2.3.1.54)
Alternative name(s):
Pyruvate formate-lyase 3
Gene namesi
Name:ybiW
Ordered Locus Names:b0823, JW0807
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13328 ybiW

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001666901 – 810Putative formate acetyltransferase 3Add BLAST810

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei786Glycine radicalPROSITE-ProRule annotation1

Keywords - PTMi

Organic radical

Proteomic databases

PaxDbiP75793
PRIDEiP75793

Interactioni

Protein-protein interaction databases

BioGridi4259978, 3 interactors
IntActiP75793, 6 interactors
STRINGi316385.ECDH10B_0892

Structurei

3D structure databases

ProteinModelPortaliP75793
SMRiP75793
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 682PFLPROSITE-ProRule annotationAdd BLAST672
Domaini689 – 810Glycine radicalPROSITE-ProRule annotationAdd BLAST122

Phylogenomic databases

eggNOGiENOG4105C6N Bacteria
COG1882 LUCA
HOGENOMiHOG000274400
InParanoidiP75793
KOiK00656
PhylomeDBiP75793

Family and domain databases

InterProiView protein in InterPro
IPR005949 Form_AcTrfase
IPR019777 Form_AcTrfase_GR_CS
IPR001150 Gly_radical
IPR010098 PFL2/GDeHydtase_fam
IPR004184 PFL_dom
PfamiView protein in Pfam
PF01228 Gly_radical, 1 hit
PF02901 PFL-like, 1 hit
PIRSFiPIRSF000379 For_Ac_trans_1, 1 hit
TIGRFAMsiTIGR01774 PFL2-3, 1 hit
PROSITEiView protein in PROSITE
PS00850 GLY_RADICAL_1, 1 hit
PS51149 GLY_RADICAL_2, 1 hit
PS51554 PFL, 1 hit

Sequencei

Sequence statusi: Complete.

P75793-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTLKLDTLS DRIKAHKNAL VHIVKPPVCT ERAQHYTEMY QQHLDKPIPV
60 70 80 90 100
RRALALAHHL ANRTIWIKHD ELIIGNQASE VRAAPIFPEY TVSWIEKEID
110 120 130 140 150
DLADRPGAGF AVSEENKRVL HEVCPWWRGQ TVQDRCYGMF TDEQKGLLAT
160 170 180 190 200
GIIKAEGNMT SGDAHLAVNF PLLLEKGLDG LREEVAERRS RINLTVLEDL
210 220 230 240 250
HGEQFLKAID IVLVAVSEHI ERFAALAREM AATETRESRR DELLAMAENC
260 270 280 290 300
DLIAHQPPQT FWQALQLCYF IQLILQIESN GHSVSFGRMD QYLYPYYRRD
310 320 330 340 350
VELNQTLDRE HAIEMLHSCW LKLLEVNKIR SGSHSKASAG SPLYQNVTIG
360 370 380 390 400
GQNLVDGQPM DAVNPLSYAI LESCGRLRST QPNLSVRYHA GMSNDFLDAC
410 420 430 440 450
VQVIRCGFGM PAFNNDEIVI PEFIKLGIEP QDAYDYAAIG CIETAVGGKW
460 470 480 490 500
GYRCTGMSFI NFARVMLAAL EGGHDATSGK VFLPQEKALS AGNFNNFDEV
510 520 530 540 550
MDAWDTQIRY YTRKSIEIEY VVDTMLEENV HDILCSALVD DCIERAKSIK
560 570 580 590 600
QGGAKYDWVS GLQVGIANLG NSLAAVKKLV FEQGAIGQQQ LAAALADDFD
610 620 630 640 650
GLTHEQLRQR LINGAPKYGN DDDTVDTLLA RAYQTYIDEL KQYHNPRYGR
660 670 680 690 700
GPVGGNYYAG TSSISANVPF GAQTMATPDG RKAHTPLAEG ASPASGTDHL
710 720 730 740 750
GPTAVIGSVG KLPTAAILGG VLLNQKLNPA TLENESDKQK LMILLRTFFE
760 770 780 790 800
VHKGWHIQYN IVSRETLLDA KKHPDQYRDL VVRVAGYSAF FTALSPDAQD
810
DIIARTEHML
Length:810
Mass (Da):90,125
Last modified:February 1, 1997 - v1
Checksum:i8578C59C67F95DE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC73910.1
AP009048 Genomic DNA Translation: BAA35504.1
PIRiG64819
RefSeqiNP_415344.1, NC_000913.3
WP_000209309.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73910; AAC73910; b0823
BAA35504; BAA35504; BAA35504
GeneIDi945444
KEGGiecj:JW0807
eco:b0823
PATRICifig|1411691.4.peg.1455

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC73910.1
AP009048 Genomic DNA Translation: BAA35504.1
PIRiG64819
RefSeqiNP_415344.1, NC_000913.3
WP_000209309.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP75793
SMRiP75793
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259978, 3 interactors
IntActiP75793, 6 interactors
STRINGi316385.ECDH10B_0892

Proteomic databases

PaxDbiP75793
PRIDEiP75793

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73910; AAC73910; b0823
BAA35504; BAA35504; BAA35504
GeneIDi945444
KEGGiecj:JW0807
eco:b0823
PATRICifig|1411691.4.peg.1455

Organism-specific databases

EchoBASEiEB3112
EcoGeneiEG13328 ybiW

Phylogenomic databases

eggNOGiENOG4105C6N Bacteria
COG1882 LUCA
HOGENOMiHOG000274400
InParanoidiP75793
KOiK00656
PhylomeDBiP75793

Enzyme and pathway databases

UniPathwayi
UPA00920;UER00891

BioCyciEcoCyc:G6426-MONOMER

Miscellaneous databases

PROiPR:P75793

Family and domain databases

InterProiView protein in InterPro
IPR005949 Form_AcTrfase
IPR019777 Form_AcTrfase_GR_CS
IPR001150 Gly_radical
IPR010098 PFL2/GDeHydtase_fam
IPR004184 PFL_dom
PfamiView protein in Pfam
PF01228 Gly_radical, 1 hit
PF02901 PFL-like, 1 hit
PIRSFiPIRSF000379 For_Ac_trans_1, 1 hit
TIGRFAMsiTIGR01774 PFL2-3, 1 hit
PROSITEiView protein in PROSITE
PS00850 GLY_RADICAL_1, 1 hit
PS51149 GLY_RADICAL_2, 1 hit
PS51554 PFL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPFLF_ECOLI
AccessioniPrimary (citable) accession number: P75793
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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Main funding by: National Institutes of Health

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