UniProtKB - P75746 (PXPA_ECOLI)
Protein
5-oxoprolinase subunit A
Gene
pxpA
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.UniRule annotation1 Publication
Catalytic activityi
- EC:3.5.2.9UniRule annotation1 Publication
GO - Molecular functioni
- 5-oxoprolinase (ATP-hydrolyzing) activity Source: UniProtKB-UniRule
- ATP binding Source: UniProtKB-UniRule
GO - Biological processi
- carbohydrate metabolic process Source: InterPro
- nitrogen compound metabolic process Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:G6382-MONOMER MetaCyc:G6382-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: 5-oxoprolinase subunit AUniRule annotationCurated (EC:3.5.2.9UniRule annotation1 Publication)Short name: 5-OPase subunit AUniRule annotationCurated Alternative name(s): 5-oxoprolinase (ATP-hydrolyzing) subunit AUniRule annotationCurated |
Gene namesi | Name:pxpA1 PublicationUniRule annotation Synonyms:ybgL Ordered Locus Names:b0713, JW0703 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Pathology & Biotechi
Disruption phenotypei
Deletion of the gene slows growth on minimal medium with ammonium as nitrogen source.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000185007 | 1 – 244 | 5-oxoprolinase subunit AAdd BLAST | 244 |
Proteomic databases
jPOSTi | P75746 |
PaxDbi | P75746 |
PRIDEi | P75746 |
Interactioni
Subunit structurei
Forms a complex composed of PxpA, PxpB and PxpC.
UniRule annotationProtein-protein interaction databases
BioGRIDi | 4259933, 106 interactors |
DIPi | DIP-11398N |
IntActi | P75746, 4 interactors |
STRINGi | 511145.b0713 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P75746 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P75746 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG1540, Bacteria |
HOGENOMi | CLU_069535_0_0_6 |
InParanoidi | P75746 |
PhylomeDBi | P75746 |
Family and domain databases
HAMAPi | MF_00691, PxpA, 1 hit |
InterProi | View protein in InterPro IPR011330, Glyco_hydro/deAcase_b/a-brl IPR005501, LamB/YcsF/PxpA-like |
PANTHERi | PTHR30292, PTHR30292, 1 hit |
Pfami | View protein in Pfam PF03746, LamB_YcsF, 1 hit |
SUPFAMi | SSF88713, SSF88713, 1 hit |
i Sequence
Sequence statusi: Complete.
P75746-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKIDLNADLG EGCASDAELL TLVSSANIAC GFHAGDAQIM QACVREAIKN
60 70 80 90 100
GVAIGAHPSF PDRENFGRSA MQLPPETVYA QTLYQIGALA TIARAQGGVM
110 120 130 140 150
RHVKPHGMLY NQAAKEAQLA DAIARAVYAC DPALILVGLA GSELIRAGKQ
160 170 180 190 200
YGLTTREEVF ADRGYQADGS LVPRSQSGAL IENEEQALAQ TLEMVQHGRV
210 220 230 240
KSITGEWATV AAQTVCLHGD GEHALAFARR LRSAFAEKGI VVAA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC73807.1 AP009048 Genomic DNA Translation: BAA35377.1 |
PIRi | H64806 |
RefSeqi | NP_415241.1, NC_000913.3 WP_000687112.1, NZ_SSZK01000033.1 |
Genome annotation databases
EnsemblBacteriai | AAC73807; AAC73807; b0713 BAA35377; BAA35377; BAA35377 |
GeneIDi | 945318 |
KEGGi | ecj:JW0703 eco:b0713 |
PATRICi | fig|511145.12.peg.743 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC73807.1 AP009048 Genomic DNA Translation: BAA35377.1 |
PIRi | H64806 |
RefSeqi | NP_415241.1, NC_000913.3 WP_000687112.1, NZ_SSZK01000033.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1XW8 | X-ray | 2.00 | A | 1-244 | [»] | |
SMRi | P75746 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4259933, 106 interactors |
DIPi | DIP-11398N |
IntActi | P75746, 4 interactors |
STRINGi | 511145.b0713 |
Proteomic databases
jPOSTi | P75746 |
PaxDbi | P75746 |
PRIDEi | P75746 |
Genome annotation databases
EnsemblBacteriai | AAC73807; AAC73807; b0713 BAA35377; BAA35377; BAA35377 |
GeneIDi | 945318 |
KEGGi | ecj:JW0703 eco:b0713 |
PATRICi | fig|511145.12.peg.743 |
Organism-specific databases
EchoBASEi | EB3092 |
Phylogenomic databases
eggNOGi | COG1540, Bacteria |
HOGENOMi | CLU_069535_0_0_6 |
InParanoidi | P75746 |
PhylomeDBi | P75746 |
Enzyme and pathway databases
BioCyci | EcoCyc:G6382-MONOMER MetaCyc:G6382-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P75746 |
PROi | PR:P75746 |
Family and domain databases
HAMAPi | MF_00691, PxpA, 1 hit |
InterProi | View protein in InterPro IPR011330, Glyco_hydro/deAcase_b/a-brl IPR005501, LamB/YcsF/PxpA-like |
PANTHERi | PTHR30292, PTHR30292, 1 hit |
Pfami | View protein in Pfam PF03746, LamB_YcsF, 1 hit |
SUPFAMi | SSF88713, SSF88713, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PXPA_ECOLI | |
Accessioni | P75746Primary (citable) accession number: P75746 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 134 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families