UniProtKB - P75745 (PXPC_ECOLI)
Protein
5-oxoprolinase subunit C
Gene
pxpC
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.1 Publication
Catalytic activityi
- EC:3.5.2.91 Publication
GO - Molecular functioni
- 5-oxoprolinase (ATP-hydrolyzing) activity Source: UniProtKB-EC
- ATP binding Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:G6381-MONOMER MetaCyc:G6381-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: 5-oxoprolinase subunit CCurated (EC:3.5.2.91 Publication)Short name: 5-OPase subunit CCurated Alternative name(s): 5-oxoprolinase (ATP-hydrolyzing) subunit CCurated |
Gene namesi | Name:pxpC1 Publication Synonyms:ybgK Ordered Locus Names:b0712, JW0702 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Pathology & Biotechi
Disruption phenotypei
Deletion of the gene slows growth on minimal medium with ammonium as nitrogen source.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000168709 | 1 – 310 | 5-oxoprolinase subunit CAdd BLAST | 310 |
Proteomic databases
jPOSTi | P75745 |
PaxDbi | P75745 |
PRIDEi | P75745 |
Interactioni
Subunit structurei
Forms a complex composed of PxpA, PxpB and PxpC.
By similarityProtein-protein interaction databases
BioGRIDi | 4259922, 246 interactors 849693, 1 interactor |
DIPi | DIP-11397N |
IntActi | P75745, 7 interactors |
STRINGi | 511145.b0712 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P75745 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the PxpC family.Curated
Phylogenomic databases
eggNOGi | COG1984, Bacteria |
HOGENOMi | CLU_028967_0_3_6 |
InParanoidi | P75745 |
PhylomeDBi | P75745 |
Family and domain databases
Gene3Di | 2.40.100.10, 1 hit |
InterProi | View protein in InterPro IPR003778, CT_A_B IPR029000, Cyclophilin-like_dom_sf |
Pfami | View protein in Pfam PF02626, CT_A_B, 1 hit |
SMARTi | View protein in SMART SM00797, AHS2, 1 hit |
SUPFAMi | SSF50891, SSF50891, 1 hit |
TIGRFAMsi | TIGR00724, urea_amlyse_rel, 1 hit |
i Sequence
Sequence statusi: Complete.
P75745-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLKIIRAGMY TTVQDGGRHG FRQSGISHCG ALDMPALRIA NLLVGNDANA
60 70 80 90 100
PALEITLGQL TVEFETDGWF ALTGAGCEAR LDDNAVWTGW RLPMKAGQRL
110 120 130 140 150
TLKRPQHGMR SYLAVAGGID VPPVMGSCST DLKVGIGGLE GRLLKDGDRL
160 170 180 190 200
PIGKSKRDSM EAQGVKQLLW GNRIRALPGP EYHEFDRASQ DAFWRSPWQL
210 220 230 240 250
SSQSNRMGYR LQGQILKRTT DRELLSHGLL PGVVQVPHNG QPIVLMNDAQ
260 270 280 290 300
TTGGYPRIAC IIEADMYHLA QIPLGQPIHF VQCSLEEALK ARQDQQRYFE
310
QLAWRLHNEN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC73806.1 AP009048 Genomic DNA Translation: BAA35376.1 |
PIRi | G64806 |
RefSeqi | NP_415240.1, NC_000913.3 WP_000912724.1, NZ_SSZK01000033.1 |
Genome annotation databases
EnsemblBacteriai | AAC73806; AAC73806; b0712 BAA35376; BAA35376; BAA35376 |
GeneIDi | 57729890 945317 |
KEGGi | ecj:JW0702 eco:b0712 |
PATRICi | fig|1411691.4.peg.1561 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC73806.1 AP009048 Genomic DNA Translation: BAA35376.1 |
PIRi | G64806 |
RefSeqi | NP_415240.1, NC_000913.3 WP_000912724.1, NZ_SSZK01000033.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5DUD | X-ray | 2.80 | A/C | 1-310 | [»] | |
SMRi | P75745 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4259922, 246 interactors 849693, 1 interactor |
DIPi | DIP-11397N |
IntActi | P75745, 7 interactors |
STRINGi | 511145.b0712 |
Proteomic databases
jPOSTi | P75745 |
PaxDbi | P75745 |
PRIDEi | P75745 |
Genome annotation databases
EnsemblBacteriai | AAC73806; AAC73806; b0712 BAA35376; BAA35376; BAA35376 |
GeneIDi | 57729890 945317 |
KEGGi | ecj:JW0702 eco:b0712 |
PATRICi | fig|1411691.4.peg.1561 |
Organism-specific databases
EchoBASEi | EB3091 |
Phylogenomic databases
eggNOGi | COG1984, Bacteria |
HOGENOMi | CLU_028967_0_3_6 |
InParanoidi | P75745 |
PhylomeDBi | P75745 |
Enzyme and pathway databases
BioCyci | EcoCyc:G6381-MONOMER MetaCyc:G6381-MONOMER |
Miscellaneous databases
PROi | PR:P75745 |
Family and domain databases
Gene3Di | 2.40.100.10, 1 hit |
InterProi | View protein in InterPro IPR003778, CT_A_B IPR029000, Cyclophilin-like_dom_sf |
Pfami | View protein in Pfam PF02626, CT_A_B, 1 hit |
SMARTi | View protein in SMART SM00797, AHS2, 1 hit |
SUPFAMi | SSF50891, SSF50891, 1 hit |
TIGRFAMsi | TIGR00724, urea_amlyse_rel, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PXPC_ECOLI | |
Accessioni | P75745Primary (citable) accession number: P75745 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 1, 1997 | |
Last modified: | April 7, 2021 | |
This is version 134 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families