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Entry version 158 (07 Apr 2021)
Sequence version 1 (01 Feb 1997)
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Protein

Dipeptide permease D

Gene

dtpD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable proton-dependent permease that transports dipeptides.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPeptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:B0709-MONOMER
MetaCyc:B0709-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.17.1.4, the proton-dependent oligopeptide transporter (pot/ptr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dipeptide permease D
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dtpD
Synonyms:ybgH
Ordered Locus Names:b0709, JW0699
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 48PeriplasmicSequence analysisAdd BLAST14
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 77CytoplasmicSequence analysis8
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Topological domaini99 – 100PeriplasmicSequence analysis2
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Topological domaini122 – 137CytoplasmicSequence analysisAdd BLAST16
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 166PeriplasmicSequence analysis8
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 211CytoplasmicSequence analysisAdd BLAST24
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Topological domaini233 – 234PeriplasmicSequence analysis2
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Topological domaini256 – 266CytoplasmicSequence analysisAdd BLAST11
Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
Topological domaini288 – 311PeriplasmicSequence analysisAdd BLAST24
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Topological domaini333 – 343CytoplasmicSequence analysisAdd BLAST11
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Topological domaini365 – 378PeriplasmicSequence analysisAdd BLAST14
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Topological domaini400 – 412CytoplasmicSequence analysisAdd BLAST13
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Topological domaini434 – 461PeriplasmicSequence analysisAdd BLAST28
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Topological domaini483 – 493CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000643281 – 493Dipeptide permease DAdd BLAST493

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P75742

PRoteomics IDEntifications database

More...
PRIDEi
P75742

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4263335, 112 interactors
851691, 1 interactor

Database of interacting proteins

More...
DIPi
DIP-11394N

Protein interaction database and analysis system

More...
IntActi
P75742, 2 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b0709

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1493
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P75742

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG3104, Bacteria

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P75742

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P75742

Family and domain databases

Conserved Domains Database

More...
CDDi
cd17346, MFS_DtpA_like, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01880, PTR2_DtpD_subfam, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023777, AA/pep_transptr_DtpD
IPR005279, Dipep/tripep_permease
IPR020846, MFS_dom
IPR036259, MFS_trans_sf
IPR000109, POT_fam
IPR018456, PTR2_symporter_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11654, PTHR11654, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00854, PTR2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473, SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00924, yjdL_sub1_fam, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850, MFS, 1 hit
PS01022, PTR2_1, 1 hit
PS01023, PTR2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P75742-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKHASQPRA IYYVVALQIW EYFSFYGMRA LLILYLTNQL KYNDTHAYEL
60 70 80 90 100
FSAYCSLVYV TPILGGFLAD KVLGNRMAVM LGALLMAIGH VVLGASEIHP
110 120 130 140 150
SFLYLSLAII VCGYGLFKSN VSCLLGELYE PTDPRRDGGF SLMYAAGNVG
160 170 180 190 200
SIIAPIACGY AQEEYSWAMG FGLAAVGMIA GLVIFLCGNR HFTHTRGVNK
210 220 230 240 250
KVLRATNFLL PNWGWLLVLL VATPALITIL FWKEWSVYAL IVATIIGLGV
260 270 280 290 300
LAKIYRKAEN QKQRKELGLI VTLTFFSMLF WAFAQQGGSS ISLYIDRFVN
310 320 330 340 350
RDMFGYTVPT AMFQSINAFA VMLCGVFLAW VVKESVAGNR TVRIWGKFAL
360 370 380 390 400
GLGLMSAGFC ILTLSARWSA MYGHSSLPLM VLGLAVMGFA ELFIDPVAMS
410 420 430 440 450
QITRIEIPGV TGVLTGIYML LSGAIANYLA GVIADQTSQA SFDASGAINY
460 470 480 490
SINAYIEVFD QITWGALACV GLVLMIWLYQ ALKFRNRALA LES
Length:493
Mass (Da):54,159
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i930DB6EDAE448B7D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC73803.1
AP009048 Genomic DNA Translation: BAA35368.1

Protein sequence database of the Protein Information Resource

More...
PIRi
D64806

NCBI Reference Sequences

More...
RefSeqi
NP_415237.1, NC_000913.3
WP_001032689.1, NZ_SSZK01000033.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC73803; AAC73803; b0709
BAA35368; BAA35368; BAA35368

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
947368

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW0699
eco:b0709

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.1564

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC73803.1
AP009048 Genomic DNA Translation: BAA35368.1
PIRiD64806
RefSeqiNP_415237.1, NC_000913.3
WP_001032689.1, NZ_SSZK01000033.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Q65X-ray3.40A1-493[»]
SMRiP75742
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi4263335, 112 interactors
851691, 1 interactor
DIPiDIP-11394N
IntActiP75742, 2 interactors
STRINGi511145.b0709

Protein family/group databases

TCDBi2.A.17.1.4, the proton-dependent oligopeptide transporter (pot/ptr) family

Proteomic databases

PaxDbiP75742
PRIDEiP75742

Genome annotation databases

EnsemblBacteriaiAAC73803; AAC73803; b0709
BAA35368; BAA35368; BAA35368
GeneIDi947368
KEGGiecj:JW0699
eco:b0709
PATRICifig|1411691.4.peg.1564

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB3088

Phylogenomic databases

eggNOGiCOG3104, Bacteria
InParanoidiP75742
PhylomeDBiP75742

Enzyme and pathway databases

BioCyciEcoCyc:B0709-MONOMER
MetaCyc:B0709-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P75742

Family and domain databases

CDDicd17346, MFS_DtpA_like, 1 hit
HAMAPiMF_01880, PTR2_DtpD_subfam, 1 hit
InterProiView protein in InterPro
IPR023777, AA/pep_transptr_DtpD
IPR005279, Dipep/tripep_permease
IPR020846, MFS_dom
IPR036259, MFS_trans_sf
IPR000109, POT_fam
IPR018456, PTR2_symporter_CS
PANTHERiPTHR11654, PTHR11654, 1 hit
PfamiView protein in Pfam
PF00854, PTR2, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit
TIGRFAMsiTIGR00924, yjdL_sub1_fam, 1 hit
PROSITEiView protein in PROSITE
PS50850, MFS, 1 hit
PS01022, PTR2_1, 1 hit
PS01023, PTR2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDTPD_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P75742
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: April 7, 2021
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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