UniProtKB - P75726 (CILA_ECOLI)
Protein
Citrate lyase alpha chain
Gene
citF
Organism
Escherichia coli (strain K12)
Status
Functioni
Represents a citrate:acetyl-ACP transferase.By similarity
Catalytic activityi
GO - Molecular functioni
- citrate (pro-3S)-lyase activity Source: UniProtKB-EC
- citrate CoA-transferase activity Source: UniProtKB-EC
GO - Biological processi
- acetyl-CoA metabolic process Source: InterPro
Keywordsi
Molecular function | Lyase, Transferase |
Enzyme and pathway databases
BioCyci | EcoCyc:CITTRANS-MONOMER MetaCyc:CITTRANS-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:citF Synonyms:ybdV Ordered Locus Names:b0615, JW5087 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
Other locations
- citrate lyase complex Source: InterPro
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000089752 | 1 – 510 | Citrate lyase alpha chainAdd BLAST | 510 |
Proteomic databases
PaxDbi | P75726 |
PRIDEi | P75726 |
Expressioni
Inductioni
Repressed by H-NS. Part of the citCDEFXG operon.1 Publication
Interactioni
Subunit structurei
Oligomer with a subunit composition of (alpha,beta,gamma)6.
By similarityProtein-protein interaction databases
BioGRIDi | 4261998, 7 interactors |
ComplexPortali | CPX-4781, Citrate lyase complex |
STRINGi | 511145.b0615 |
Family & Domainsi
Phylogenomic databases
eggNOGi | COG3051, Bacteria |
HOGENOMi | CLU_046521_2_0_6 |
InParanoidi | P75726 |
PhylomeDBi | P75726 |
Family and domain databases
InterProi | View protein in InterPro IPR006472, Citrate_lyase_asu IPR037171, NagB/RpiA_transferase-like |
PANTHERi | PTHR40596, PTHR40596, 1 hit |
Pfami | View protein in Pfam PF04223, CitF, 1 hit |
PIRSFi | PIRSF009451, Citrt_lyas_alpha, 1 hit |
SUPFAMi | SSF100950, SSF100950, 2 hits |
TIGRFAMsi | TIGR01584, citF, 1 hit |
i Sequence
Sequence statusi: Complete.
P75726-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTQKIEQSQR QERVAAWNRR AECDLAAFQN SPKQTYQAEK ARDRKLCANL
60 70 80 90 100
EEAIRRSGLQ DGMTVSFHHA FRGGDLTVNM VMDVIAKMGF KNLTLASSSL
110 120 130 140 150
SDCHAPLVEH IRQGVVTRIY TSGLRGPLAE EISRGLLAEP VQIHSHGGRV
160 170 180 190 200
HLVQSGELNI DVAFLGVPSC DEFGNANGYT GKACCGSLGY AIVDADNAKQ
210 220 230 240 250
VVMLTEELLP YPHNPASIEQ DQVDLIVKVD RVGDAAKIGA GATRMTTNPR
260 270 280 290 300
ELLIARSAAD VIVNSGYFKE GFSMQTGTGG ASLAVTRFLE DKMRSRDIRA
310 320 330 340 350
DFALGGITAT MVDLHEKGLI RKLLDVQSFD SHAAQSLARN PNHIEISANQ
360 370 380 390 400
YANWGSKGAS VDRLDVVVLS ALEIDTQFNV NVLTGSDGVL RGASGGHCDT
410 420 430 440 450
AIASALSIIV APLVRGRIPT LVDNVLTCIT PGSSVDILVT DHGIAVNPAR
460 470 480 490 500
PELAERLQEA GIKVVSIEWL RERARLLTGE PQPIEFTDRV VAVVRYRDGS
510
VIDVVHQVKE
Sequence cautioni
The sequence AAB40815 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U82598 Genomic DNA Translation: AAB40815.1 Different initiation. U00096 Genomic DNA Translation: AAC73716.1 AP009048 Genomic DNA Translation: BAA35251.2 |
PIRi | E64795 |
RefSeqi | NP_415148.1, NC_000913.3 WP_000192242.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC73716; AAC73716; b0615 BAA35251; BAA35251; BAA35251 |
GeneIDi | 945230 |
KEGGi | ecj:JW5087 eco:b0615 |
PATRICi | fig|1411691.4.peg.1653 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U82598 Genomic DNA Translation: AAB40815.1 Different initiation. U00096 Genomic DNA Translation: AAC73716.1 AP009048 Genomic DNA Translation: BAA35251.2 |
PIRi | E64795 |
RefSeqi | NP_415148.1, NC_000913.3 WP_000192242.1, NZ_LN832404.1 |
3D structure databases
SMRi | P75726 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4261998, 7 interactors |
ComplexPortali | CPX-4781, Citrate lyase complex |
STRINGi | 511145.b0615 |
Proteomic databases
PaxDbi | P75726 |
PRIDEi | P75726 |
Genome annotation databases
EnsemblBacteriai | AAC73716; AAC73716; b0615 BAA35251; BAA35251; BAA35251 |
GeneIDi | 945230 |
KEGGi | ecj:JW5087 eco:b0615 |
PATRICi | fig|1411691.4.peg.1653 |
Organism-specific databases
EchoBASEi | EB3311 |
Phylogenomic databases
eggNOGi | COG3051, Bacteria |
HOGENOMi | CLU_046521_2_0_6 |
InParanoidi | P75726 |
PhylomeDBi | P75726 |
Enzyme and pathway databases
BioCyci | EcoCyc:CITTRANS-MONOMER MetaCyc:CITTRANS-MONOMER |
Miscellaneous databases
PROi | PR:P75726 |
Family and domain databases
InterProi | View protein in InterPro IPR006472, Citrate_lyase_asu IPR037171, NagB/RpiA_transferase-like |
PANTHERi | PTHR40596, PTHR40596, 1 hit |
Pfami | View protein in Pfam PF04223, CitF, 1 hit |
PIRSFi | PIRSF009451, Citrt_lyas_alpha, 1 hit |
SUPFAMi | SSF100950, SSF100950, 2 hits |
TIGRFAMsi | TIGR01584, citF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CILA_ECOLI | |
Accessioni | P75726Primary (citable) accession number: P75726 Secondary accession number(s): P77102, Q9R7T5, Q9R7T6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |