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UniProtKB - P75719 (RZPD_ECOLI)
Protein
Prophage Rz endopeptidase RzpD
Gene
rzpD
Organism
Escherichia coli (strain K12)
Status
Functioni
Necessary for host cell lysis. It is believed to code for an endopeptidase that cleaves the amino-carboxyl cross-link between the diaminopimelic acid and D-alanine residues in the murein component of the bacterial cell wall (By similarity).
By similarityMiscellaneous
Encoded by the cryptic lambdoid prophage DLP12.
GO - Molecular functioni
- peptidase activity Source: UniProtKB-KW
GO - Biological processi
- cytolysis Source: UniProtKB-KW
- defense response to bacterium Source: UniProtKB-KW
- viral release from host cell Source: InterPro
Keywordsi
Molecular function | Antimicrobial, Bacteriolytic enzyme, Hydrolase, Protease |
Enzyme and pathway databases
BioCyci | EcoCyc:G6311-MONOMER |
Protein family/group databases
MEROPSi | X19.001 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:rzpD Synonyms:ybcT Ordered Locus Names:b0556, JW5079 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000077572 | 1 – 153 | Prophage Rz endopeptidase RzpDAdd BLAST | 153 |
Proteomic databases
PaxDbi | P75719 |
PRIDEi | P75719 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4262925, 2 interactors |
STRINGi | 511145.b0556 |
Family & Domainsi
Phylogenomic databases
eggNOGi | ENOG50330HV, Bacteria |
HOGENOMi | CLU_117687_2_0_6 |
InParanoidi | P75719 |
OMAi | QCVSTAS |
PhylomeDBi | P75719 |
Family and domain databases
HAMAPi | MF_04137, I_SPANIN_LAMBDA, 1 hit |
InterProi | View protein in InterPro IPR004929, I-spanin |
Pfami | View protein in Pfam PF03245, Phage_lysis, 1 hit |
i Sequence
Sequence statusi: Complete.
P75719-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRVTAIISA LIICIIVSLS WAVNHYRDNA IAYKVQRDKN ARELKLANAA
60 70 80 90 100
ITDMQMRQRD VAALDAKYTK ELADAKAEND ALRDDVAAGR RRLHIKAVCQ
110 120 130 140 150
SVREATTASG VDNAASPRLA DTAERDYFTL RERLITMQKQ LEGTQKYINE
QCR
Sequence cautioni
The sequence AAB40752 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U82598 Genomic DNA Translation: AAB40752.1 Different initiation. U00096 Genomic DNA Translation: AAC73657.1 AP009048 Genomic DNA Translation: BAE76331.1 |
PIRi | B64788 |
RefSeqi | NP_415088.1, NC_000913.3 |
Genome annotation databases
EnsemblBacteriai | AAC73657; AAC73657; b0556 BAE76331; BAE76331; BAE76331 |
GeneIDi | 945929 |
KEGGi | ecj:JW5079 eco:b0556 |
PATRICi | fig|1411691.4.peg.1719 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U82598 Genomic DNA Translation: AAB40752.1 Different initiation. U00096 Genomic DNA Translation: AAC73657.1 AP009048 Genomic DNA Translation: BAE76331.1 |
PIRi | B64788 |
RefSeqi | NP_415088.1, NC_000913.3 |
3D structure databases
AlphaFoldDBi | P75719 |
SMRi | P75719 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4262925, 2 interactors |
STRINGi | 511145.b0556 |
Protein family/group databases
MEROPSi | X19.001 |
Proteomic databases
PaxDbi | P75719 |
PRIDEi | P75719 |
Genome annotation databases
EnsemblBacteriai | AAC73657; AAC73657; b0556 BAE76331; BAE76331; BAE76331 |
GeneIDi | 945929 |
KEGGi | ecj:JW5079 eco:b0556 |
PATRICi | fig|1411691.4.peg.1719 |
Organism-specific databases
EchoBASEi | EB3400 |
Phylogenomic databases
eggNOGi | ENOG50330HV, Bacteria |
HOGENOMi | CLU_117687_2_0_6 |
InParanoidi | P75719 |
OMAi | QCVSTAS |
PhylomeDBi | P75719 |
Enzyme and pathway databases
BioCyci | EcoCyc:G6311-MONOMER |
Miscellaneous databases
PROi | PR:P75719 |
Family and domain databases
HAMAPi | MF_04137, I_SPANIN_LAMBDA, 1 hit |
InterProi | View protein in InterPro IPR004929, I-spanin |
Pfami | View protein in Pfam PF03245, Phage_lysis, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RZPD_ECOLI | |
Accessioni | P75719Primary (citable) accession number: P75719 Secondary accession number(s): P77084, Q2MBM5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |