UniProtKB - P75713 (ALLE_ECOLI)
Protein
(S)-ureidoglycine aminohydrolase
Gene
allE
Organism
Escherichia coli (strain K12)
Status
Functioni
Involved in the anaerobic nitrogen utilization via the assimilation of allantoin. Catalyzes the second stereospecific hydrolysis reaction (deamination) of the allantoin degradation pathway, producing S-ureidoglycolate and ammonia from S-ureidoglycine.2 Publications
Catalytic activityi
- EC:3.5.3.261 Publication1 Publication
Cofactori
Mn2+1 PublicationNote: Also able to use Co2+).1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 196 | ManganeseBy similarity | 1 | |
Binding sitei | 196 | SubstrateBy similarity | 1 | |
Metal bindingi | 198 | ManganeseBy similarity | 1 | |
Metal bindingi | 202 | ManganeseBy similarity | 1 | |
Metal bindingi | 236 | ManganeseBy similarity | 1 | |
Binding sitei | 236 | SubstrateBy similarity | 1 | |
Binding sitei | 249 | SubstrateBy similarity | 1 | |
Binding sitei | 253 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- manganese ion binding Source: EcoCyc
- ureidoglycine aminohydrolase activity Source: EcoCyc
GO - Biological processi
- purine nucleobase metabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Biological process | Purine metabolism |
Ligand | Manganese, Metal-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:G6284-MONOMER MetaCyc:G6284-MONOMER |
BRENDAi | 3.5.3.26, 2026 |
Names & Taxonomyi
Protein namesi | Recommended name: (S)-ureidoglycine aminohydrolase1 Publication (EC:3.5.3.261 Publication1 Publication)Short name: UGHY1 Publication Short name: UGlyAH |
Gene namesi | Name:allE Synonyms:glxB6, ylbA Ordered Locus Names:b0515, JW0503 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 2 Publications
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000168644 | 1 – 261 | (S)-ureidoglycine aminohydrolaseAdd BLAST | 261 |
Proteomic databases
jPOSTi | P75713 |
PaxDbi | P75713 |
PRIDEi | P75713 |
Expressioni
Inductioni
By glyoxylate and allantoin under anaerobic conditions.1 Publication
Interactioni
Subunit structurei
Monomer.
2 PublicationsProtein-protein interaction databases
BioGRIDi | 4262016, 8 interactors |
DIPi | DIP-12689N |
IntActi | P75713, 7 interactors |
STRINGi | 511145.b0515 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P75713 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P75713 |
Family & Domainsi
Sequence similaritiesi
Belongs to the UGHY family.Curated
Phylogenomic databases
eggNOGi | COG3257, Bacteria |
HOGENOMi | CLU_056083_3_0_6 |
InParanoidi | P75713 |
PhylomeDBi | P75713 |
Family and domain databases
Gene3Di | 2.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR017627, CHP03214_cupin IPR013096, Cupin_2 IPR008579, DUF861_Cupin_3 IPR014710, RmlC-like_jellyroll IPR011051, RmlC_Cupin_sf |
Pfami | View protein in Pfam PF07883, Cupin_2, 1 hit PF05899, Cupin_3, 1 hit |
SUPFAMi | SSF51182, SSF51182, 1 hit |
TIGRFAMsi | TIGR03214, ura-cupin, 1 hit |
i Sequence
Sequence statusi: Complete.
P75713-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGYLNNVTGY REDLLANRAI VKHGNFALLT PDGLVKNIIP GFENCDATIL
60 70 80 90 100
STPKLGASFV DYLVTLHQNG GNQQGFGGEG IETFLYVISG NITAKAEGKT
110 120 130 140 150
FALSEGGYLY CPPGSLMTFV NAQAEDSQIF LYKRRYVPVE GYAPWLVSGN
160 170 180 190 200
ASELERIHYE GMDDVILLDF LPKELGFDMN MHILSFAPGA SHGYIETHVQ
210 220 230 240 250
EHGAYILSGQ GVYNLDNNWI PVKKGDYIFM GAYSLQAGYG VGRGEAFSYI
260
YSKDCNRDVE I
Sequence cautioni
The sequence AAB93856 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 204 | A → T in AAB93856 (PubMed:10601204).Curated | 1 | |
Sequence conflicti | 204 | A → T in AAB40267 (Ref. 2) Curated | 1 | |
Sequence conflicti | 225 – 261 | GDYIF…RDVEI → RRLHLYGRLFFTGWLWCRAW in AAB40267 (Ref. 2) CuratedAdd BLAST | 37 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U89279 Genomic DNA Translation: AAB93856.1 Frameshift. U82664 Genomic DNA Translation: AAB40267.1 U00096 Genomic DNA Translation: AAC73617.1 AP009048 Genomic DNA Translation: BAE76293.1 |
PIRi | B64783 |
RefSeqi | NP_415048.1, NC_000913.3 WP_000540997.1, NZ_SSZK01000024.1 |
Genome annotation databases
EnsemblBacteriai | AAC73617; AAC73617; b0515 BAE76293; BAE76293; BAE76293 |
GeneIDi | 945149 |
KEGGi | ecj:JW0503 eco:b0515 |
PATRICi | fig|511145.12.peg.535 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U89279 Genomic DNA Translation: AAB93856.1 Frameshift. U82664 Genomic DNA Translation: AAB40267.1 U00096 Genomic DNA Translation: AAC73617.1 AP009048 Genomic DNA Translation: BAE76293.1 |
PIRi | B64783 |
RefSeqi | NP_415048.1, NC_000913.3 WP_000540997.1, NZ_SSZK01000024.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1RC6 | X-ray | 2.60 | A/B | 1-261 | [»] | |
SMRi | P75713 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4262016, 8 interactors |
DIPi | DIP-12689N |
IntActi | P75713, 7 interactors |
STRINGi | 511145.b0515 |
Proteomic databases
jPOSTi | P75713 |
PaxDbi | P75713 |
PRIDEi | P75713 |
Genome annotation databases
EnsemblBacteriai | AAC73617; AAC73617; b0515 BAE76293; BAE76293; BAE76293 |
GeneIDi | 945149 |
KEGGi | ecj:JW0503 eco:b0515 |
PATRICi | fig|511145.12.peg.535 |
Organism-specific databases
EchoBASEi | EB3387 |
Phylogenomic databases
eggNOGi | COG3257, Bacteria |
HOGENOMi | CLU_056083_3_0_6 |
InParanoidi | P75713 |
PhylomeDBi | P75713 |
Enzyme and pathway databases
BioCyci | EcoCyc:G6284-MONOMER MetaCyc:G6284-MONOMER |
BRENDAi | 3.5.3.26, 2026 |
Miscellaneous databases
EvolutionaryTracei | P75713 |
PROi | PR:P75713 |
Family and domain databases
Gene3Di | 2.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR017627, CHP03214_cupin IPR013096, Cupin_2 IPR008579, DUF861_Cupin_3 IPR014710, RmlC-like_jellyroll IPR011051, RmlC_Cupin_sf |
Pfami | View protein in Pfam PF07883, Cupin_2, 1 hit PF05899, Cupin_3, 1 hit |
SUPFAMi | SSF51182, SSF51182, 1 hit |
TIGRFAMsi | TIGR03214, ura-cupin, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ALLE_ECOLI | |
Accessioni | P75713Primary (citable) accession number: P75713 Secondary accession number(s): O54410, P77128, Q2MBR3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 1, 1997 | |
Last modified: | April 7, 2021 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families