UniProtKB - P75685 (RCLC_ECOLI)
Protein
Inner membrane protein RclC
Gene
rclC
Organism
Escherichia coli (strain K12)
Status
Functioni
Probably involved in reactive chlorine species (RCS) stress resistance.1 Publication
GO - Biological processi
- response to hypochlorite Source: EcoCyc
Keywordsi
Biological process | Stress response |
Enzyme and pathway databases
BioCyci | EcoCyc:G6171-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Inner membrane protein RclCAlternative name(s): Reactive chlorine resistance protein C |
Gene namesi | Name:rclC Synonyms:ykgB Ordered Locus Names:b0301, JW5038 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cell inner membrane 1 Publication; Multi-pass membrane protein 1 Publication
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 15 | PeriplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 16 – 36 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 37 – 85 | CytoplasmicSequence analysisAdd BLAST | 49 | |
Transmembranei | 86 – 106 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 107 – 112 | PeriplasmicSequence analysis | 6 | |
Transmembranei | 113 – 133 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 134 – 197 | CytoplasmicSequence analysisAdd BLAST | 64 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Mutants are more sensitive to HOCl treatment than wild-type cells.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000168566 | 1 – 197 | Inner membrane protein RclCAdd BLAST | 197 |
Proteomic databases
PaxDbi | P75685 |
PRIDEi | P75685 |
Expressioni
Inductioni
Induced by RclR in response to hypochlorous acid (HOCl).1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4259798, 5 interactors |
STRINGi | 511145.b0301 |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG3059, Bacteria |
HOGENOMi | CLU_102847_0_0_6 |
InParanoidi | P75685 |
PhylomeDBi | P75685 |
Family and domain databases
InterProi | View protein in InterPro IPR016865, RclC IPR007339, RclC-like |
PANTHERi | PTHR40106, PTHR40106, 1 hit |
Pfami | View protein in Pfam PF04224, DUF417, 1 hit |
PIRSFi | PIRSF028065, UCP028065, 1 hit |
i Sequence
Sequence statusi: Complete.
P75685-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKYLHLLSR GDKIGLTLIR LSIAIVFMWI GLLKFVPYEA DSITPFVANS
60 70 80 90 100
PLMSFFYEHP EDYKQYLTHE GEYKPEARAW QTANNTYGFS NGLGVVEVII
110 120 130 140 150
ALLVLANPVN RWLGLLGGLM AFTTPLVTLS FLITTPEAWV PALGDAHHGF
160 170 180 190
PYLSGAGRLV LKDTLMLAGA VMIMADSARE ILKQRSNESS STLKTEY
Sequence cautioni
The sequence AAB18029 differs from that shown. Reason: Frameshift.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U73857 Genomic DNA Translation: AAB18029.1 Frameshift. U00096 Genomic DNA Translation: AAC73404.2 AP009048 Genomic DNA Translation: BAE76086.1 |
PIRi | E64756 |
RefSeqi | NP_414835.2, NC_000913.3 WP_001299021.1, NZ_SSZK01000048.1 |
Genome annotation databases
EnsemblBacteriai | AAC73404; AAC73404; b0301 BAE76086; BAE76086; BAE76086 |
GeneIDi | 944974 |
KEGGi | ecj:JW5038 eco:b0301 |
PATRICi | fig|511145.12.peg.309 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U73857 Genomic DNA Translation: AAB18029.1 Frameshift. U00096 Genomic DNA Translation: AAC73404.2 AP009048 Genomic DNA Translation: BAE76086.1 |
PIRi | E64756 |
RefSeqi | NP_414835.2, NC_000913.3 WP_001299021.1, NZ_SSZK01000048.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4259798, 5 interactors |
STRINGi | 511145.b0301 |
Proteomic databases
PaxDbi | P75685 |
PRIDEi | P75685 |
Genome annotation databases
EnsemblBacteriai | AAC73404; AAC73404; b0301 BAE76086; BAE76086; BAE76086 |
GeneIDi | 944974 |
KEGGi | ecj:JW5038 eco:b0301 |
PATRICi | fig|511145.12.peg.309 |
Organism-specific databases
EchoBASEi | EB3349 |
Phylogenomic databases
eggNOGi | COG3059, Bacteria |
HOGENOMi | CLU_102847_0_0_6 |
InParanoidi | P75685 |
PhylomeDBi | P75685 |
Enzyme and pathway databases
BioCyci | EcoCyc:G6171-MONOMER |
Miscellaneous databases
PROi | PR:P75685 |
Family and domain databases
InterProi | View protein in InterPro IPR016865, RclC IPR007339, RclC-like |
PANTHERi | PTHR40106, PTHR40106, 1 hit |
Pfami | View protein in Pfam PF04224, DUF417, 1 hit |
PIRSFi | PIRSF028065, UCP028065, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RCLC_ECOLI | |
Accessioni | P75685Primary (citable) accession number: P75685 Secondary accession number(s): P71303, Q2MCC0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | April 27, 2001 | |
Last modified: | December 2, 2020 | |
This is version 126 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |