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Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.By similarity

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei70Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA repair

Enzyme and pathway databases

BioCyciMPNE272634:G1GJ3-375-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylase (EC:3.2.2.27)
Short name:
UDG
Gene namesi
Name:ung
Ordered Locus Names:MPN_235
ORF Names:MP596
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000808 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001761161 – 240Uracil-DNA glycosylaseAdd BLAST240

Interactioni

Protein-protein interaction databases

IntActiP75536, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliP75536
SMRiP75536
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK03648
OMAiQANGLCF

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

P75536-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQLLDQFLS GVLSEWKAFI LQEAKQTYFQ ELLAKLKNVE QELTPKASQV
60 70 80 90 100
FRPFSFFAPN NTKLIIYGQD PYPNPQHACG LSFASNAPKL PQSLKRMILR
110 120 130 140 150
LQQEYPELAG QNHWTKQLLE GWAQQGILLL NGVFTTNAFQ TNAHRNWGWE
160 170 180 190 200
QFNCHLLDFL LSQKLYVLLV FLGKQTENFV LKKIGGASQF ASLSYPHPSP
210 220 230 240
LTGRKFFDHP DALFKQINQW LKHHNHTPID WTNGQVQYQF
Length:240
Mass (Da):27,819
Last modified:February 1, 1997 - v1
Checksum:i8CF2B492009F4A2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA Translation: AAB96244.1
PIRiS73922
RefSeqiNP_109923.1, NC_000912.1
WP_010874592.1, NC_000912.1

Genome annotation databases

EnsemblBacteriaiAAB96244; AAB96244; MPN_235
GeneIDi877251
KEGGimpn:MPN235
PATRICifig|272634.6.peg.254

Similar proteinsi

Entry informationi

Entry nameiUNG_MYCPN
AccessioniPrimary (citable) accession number: P75536
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: February 28, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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