UniProtKB - P75531 (TRXB_MYCPN)
Protein
Thioredoxin reductase
Gene
trxB
Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Functioni
Miscellaneous
The active site is a redox-active disulfide bond.
Catalytic activityi
- EC:1.8.1.9
Cofactori
FADBy similarityNote: Binds 1 FAD per subunit.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 45 – 52 | FADBy similarity | 8 | |
Nucleotide bindingi | 288 – 297 | FADBy similarity | 10 |
GO - Molecular functioni
- thioredoxin-disulfide reductase activity Source: UniProtKB-EC
GO - Biological processi
- removal of superoxide radicals Source: InterPro
Keywordsi
Molecular function | Oxidoreductase |
Ligand | FAD, Flavoprotein, NADP |
Enzyme and pathway databases
BioCyci | MetaCyc:MONOMER-543 MPNE272634:G1GJ3-381-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:trxB Ordered Locus Names:MPN_240 ORF Names:MP591 |
Organismi | Mycoplasma pneumoniae (strain ATCC 29342 / M129) |
Taxonomic identifieri | 272634 [NCBI] |
Taxonomic lineagei | Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm By similarity
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000166738 | 1 – 315 | Thioredoxin reductaseAdd BLAST | 315 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 145 ↔ 148 | Redox-activeBy similarity |
Keywords - PTMi
Disulfide bondInteractioni
Subunit structurei
Homodimer.
By similarityFamily & Domainsi
Sequence similaritiesi
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.Curated
Keywords - Domaini
Redox-active centerPhylogenomic databases
HOGENOMi | CLU_031864_5_3_14 |
OMAi | VDNFPGY |
Family and domain databases
Gene3Di | 3.50.50.60, 2 hits |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR023753, FAD/NAD-binding_dom IPR008255, Pyr_nucl-diS_OxRdtase_2_AS IPR005982, Thioredox_Rdtase |
Pfami | View protein in Pfam PF07992, Pyr_redox_2, 1 hit |
SUPFAMi | SSF51905, SSF51905, 1 hit |
TIGRFAMsi | TIGR01292, TRX_reduct, 1 hit |
PROSITEi | View protein in PROSITE PS00573, PYRIDINE_REDOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P75531-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLKVKSDFLT KDQVIYDVAI VGAGPAGIAA GIYGKRANLN LAIIEGSTPG
60 70 80 90 100
GKVVKTNIVE NYPGYKSITG PDLGLEMYNH LIDLEPTFFY ANLIKLDKAA
110 120 130 140 150
DTFILYLDDK TVVFAKTVIY ATGMLERKLG VAKEDHFYGK GISYCAICDG
160 170 180 190 200
SLYKDQVVGV VGGGNSAIQE ALYLASMAKT VHLIHRREGF RADETALNKL
210 220 230 240 250
RNLPNVVFHL NYTVKELLGN NTLNGIVLQN TLDHSTKQID LNCVFPYIGF
260 270 280 290 300
ESITKPVEHL NLKLDPQGFL ITNEQMETSL KGLFAAGDCR SKHFRQIGTA
310
INDGIIAVLT IRDVL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U51988 Genomic DNA Translation: AAC45451.1 U00089 Genomic DNA Translation: AAB96239.1 |
PIRi | S73917 |
RefSeqi | NP_109928.1, NC_000912.1 WP_010874597.1, NC_000912.1 |
Genome annotation databases
EnsemblBacteriai | AAB96239; AAB96239; MPN_240 |
KEGGi | mpn:MPN240 |
PATRICi | fig|272634.6.peg.259 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U51988 Genomic DNA Translation: AAC45451.1 U00089 Genomic DNA Translation: AAB96239.1 |
PIRi | S73917 |
RefSeqi | NP_109928.1, NC_000912.1 WP_010874597.1, NC_000912.1 |
3D structure databases
SMRi | P75531 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | AAB96239; AAB96239; MPN_240 |
KEGGi | mpn:MPN240 |
PATRICi | fig|272634.6.peg.259 |
Phylogenomic databases
HOGENOMi | CLU_031864_5_3_14 |
OMAi | VDNFPGY |
Enzyme and pathway databases
BioCyci | MetaCyc:MONOMER-543 MPNE272634:G1GJ3-381-MONOMER |
Family and domain databases
Gene3Di | 3.50.50.60, 2 hits |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR023753, FAD/NAD-binding_dom IPR008255, Pyr_nucl-diS_OxRdtase_2_AS IPR005982, Thioredox_Rdtase |
Pfami | View protein in Pfam PF07992, Pyr_redox_2, 1 hit |
SUPFAMi | SSF51905, SSF51905, 1 hit |
TIGRFAMsi | TIGR01292, TRX_reduct, 1 hit |
PROSITEi | View protein in PROSITE PS00573, PYRIDINE_REDOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRXB_MYCPN | |
Accessioni | P75531Primary (citable) accession number: P75531 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families