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Protein

UDP-glucose 4-epimerase

Gene

galE

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).By similarity

Catalytic activityi

UDP-alpha-D-glucose = UDP-alpha-D-galactose.

Cofactori

NAD+By similarity

Pathwayi: galactose metabolism

This protein is involved in the pathway galactose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway galactose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei126NADBy similarity1
Binding sitei126SubstrateBy similarity1
Active sitei153Proton acceptorBy similarity1
Binding sitei153NADBy similarity1
Binding sitei153SubstrateBy similarity1
Binding sitei157NADBy similarity1
Binding sitei181NAD; via carbonyl oxygenBy similarity1
Binding sitei182SubstrateBy similarity1
Binding sitei230SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 17NADBy similarity2
Nucleotide bindingi37 – 42NADBy similarity6
Nucleotide bindingi59 – 60NADBy similarity2
Nucleotide bindingi81 – 85NADBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism, Galactose metabolism
LigandNAD

Enzyme and pathway databases

BioCyciMPNE272634:G1GJ3-405-MONOMER
UniPathwayi
UPA00214

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 4-epimerase (EC:5.1.3.2)
Alternative name(s):
Galactowaldenase
UDP-galactose 4-epimerase
Gene namesi
Name:galE
Ordered Locus Names:MPN_257
ORF Names:MP576
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000808 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001832101 – 338UDP-glucose 4-epimeraseAdd BLAST338

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiP75517, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliP75517
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni198 – 199Substrate bindingBy similarity2
Regioni215 – 217Substrate bindingBy similarity3
Regioni294 – 297Substrate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

KOiK01784
OMAiSDPSWNI

Family and domain databases

CDDicd05247 UDP_G4E_1_SDR_e, 1 hit
InterProiView protein in InterPro
IPR016040 NAD(P)-bd_dom
IPR036291 NAD(P)-bd_dom_sf
IPR005886 UDP_G4E
PfamiView protein in Pfam
PF16363 GDP_Man_Dehyd, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01179 galE, 1 hit

Sequencei

Sequence statusi: Complete.

P75517-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSETKSKVLV LGGLGYIGSC FIDQLLKQYP DVTVSVIDIN HTSLALQLLP
60 70 80 90 100
RQVNVHFVNL LDRAQLTDTI AQINPDVVFH FAAKTSVKES TEQPLTYFDH
110 120 130 140 150
NLVGTLNLLH ALKELQKPIQ LFFSSTAAVF GSASTLPIPE NLVLEETLAS
160 170 180 190 200
NPYGISKFLS EIVLQTLTRS PHFQVIALRY FNVAGASNPF GNFNKNTTLL
210 220 230 240 250
IPNLIKAFME KRTFFLYGDD YDTKDGSCIR DYIHVVDLCD AHLLAWKWLQ
260 270 280 290 300
ANPKVRFESF NLGSGQGFSN WEVINTAQAI FAPEQLQLKI ESRRAGDPPV
310 320 330
LVVDCTKAKR LLNFQPTRSL HKMLSDETIF YRDFYNRL
Length:338
Mass (Da):38,133
Last modified:February 1, 1997 - v1
Checksum:i9C50FF3856E68C03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA Translation: AAB96224.1
PIRiS73902
RefSeqiNP_109945.1, NC_000912.1
WP_010874614.1, NC_000912.1

Genome annotation databases

EnsemblBacteriaiAAB96224; AAB96224; MPN_257
GeneIDi876834
KEGGimpn:MPN257
PATRICifig|272634.6.peg.276

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA Translation: AAB96224.1
PIRiS73902
RefSeqiNP_109945.1, NC_000912.1
WP_010874614.1, NC_000912.1

3D structure databases

ProteinModelPortaliP75517
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP75517, 3 interactors

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB96224; AAB96224; MPN_257
GeneIDi876834
KEGGimpn:MPN257
PATRICifig|272634.6.peg.276

Phylogenomic databases

KOiK01784
OMAiSDPSWNI

Enzyme and pathway databases

UniPathwayi
UPA00214

BioCyciMPNE272634:G1GJ3-405-MONOMER

Family and domain databases

CDDicd05247 UDP_G4E_1_SDR_e, 1 hit
InterProiView protein in InterPro
IPR016040 NAD(P)-bd_dom
IPR036291 NAD(P)-bd_dom_sf
IPR005886 UDP_G4E
PfamiView protein in Pfam
PF16363 GDP_Man_Dehyd, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01179 galE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGALE_MYCPN
AccessioniPrimary (citable) accession number: P75517
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: February 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
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Main funding by: National Institutes of Health

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