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Entry version 91 (26 Feb 2020)
Sequence version 1 (01 Feb 1997)
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Protein

Cytadherence high molecular weight protein 2

Gene

hmw2

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the cytoskeleton-like structure which stabilizes the shape of the wall-less Mycoplasma. This cytoskeleton-like network of accessory proteins containing HMW proteins 1 to 5 allows the proper anchoring of cytadhesin proteins in the mycoplasmal membrane at the attachment organelle (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCytadherence, Virulence

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MPNE272634:G1GJ3-494-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytadherence high molecular weight protein 2
Alternative name(s):
Cytadherence accessory protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hmw2
Ordered Locus Names:MPN_310
ORF Names:MP526
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri272634 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000808 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000840141 – 1818Cytadherence high molecular weight protein 2Add BLAST1818

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated mainly on serine residues.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P75471

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P75471, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P75471

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili31 – 880Sequence analysisAdd BLAST850
Coiled coili919 – 1607Sequence analysisAdd BLAST689
Coiled coili1644 – 1755Sequence analysisAdd BLAST112
Coiled coili1786 – 1817Sequence analysisAdd BLAST32

Keywords - Domaini

Coiled coil

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_237675_0_0_14

Identification of Orthologs from Complete Genome Data

More...
OMAi
YKDCVSR

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016430 Cytadherence_Hmw2

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF004800 Hmw2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P75471-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNDTDKKFPL QPVYDTGFDD GYLQRDYEKC LESAAANDAQ TVELQTQLLA
60 70 80 90 100
EIKNLENEIK ALKAQESRQP DPHNNARIQS LEASLNRLVN EYNNFEFQKN
110 120 130 140 150
YMVDRVAELN NKARFFKDEL KRLQQENAAF VNSRYANWAD FQSNYQLKLD
160 170 180 190 200
QFQALIDQQN QTIKQLNEQI AANQGLIDQN VQRLQQNHSL DQQERDALLY
210 220 230 240 250
EVDHLYNELY ELENQKRLVG IEYEATYQDL VSADAELQNV YETIAQNQAN
260 270 280 290 300
FQKQCDAYWA QLKQVEQQIQ TTKQELVDEE STLKVRLNDA DFYINSRLAE
310 320 330 340 350
LDDLTSKINE RDFVSKEQAQ DVKASLANLT KEKERLSAEK DSFERLRNTA
360 370 380 390 400
LNDINRMEQE NALFAKHLEQ QQYEFERKQQ ESLLKLETEH KQLQKRIGEF
410 420 430 440 450
KIESEAKSEA LLIQERELLE KRREIDDLLT QASLEYEQQR RTNQVLKEKH
460 470 480 490 500
RQVQQHFQNL VHAKKKLDQK RHYLAEQKRI DEEQIFKLKE KIATERRELE
510 520 530 540 550
KLYLVKKQKQ DQKENDLLIF EKQLRQYQAD FENEIEEKQN ELFASQKSLQ
560 570 580 590 600
KSFTQLKNKE AELNQKAQKI AEDWAHLKQN KHHHADLEIF LEGEFNHLQQ
610 620 630 640 650
EKHKLLEART QFDNRVSLLS ARFKQKQAEL VKQKQSLEQL TAAFNKEQEA
660 670 680 690 700
VERDWKDRLA NLEKQKEMLG DKVHQFDENS LNISKKLAER ELAIKFKEKE
710 720 730 740 750
LEAAQKQLSL DNNNNAGLKL QLDKLSESLK TERLELEASK ERILDFYDES
760 770 780 790 800
SRRIADYESD LQARLAEVKT LEKNQQETAA KSERELKVAL EKLNQAKKAF
810 820 830 840 850
LQIRKQQLLE IASVKQQLAQ KANLLKNQQA ELDKQTEELE AAFLEQDTDK
860 870 880 890 900
KELEKALHSV KSKQELLERE RSFLLQKQRE FAEHVAGFKR QVHFKTTQMQ
910 920 930 940 950
RLSEFNKQQQ SEQIKRETEL KIAFADLKKD YQLFELQKNQ EFQQIEQKHK
960 970 980 990 1000
ELELLAQKQA ELKQELEQKA TALASQDQDT VQAKLDLARQ QHELELRQNA
1010 1020 1030 1040 1050
FNQASLSLNK QREQLTNQVK VLHGELKKRH EKLTLKDRLL AEKEKDQHKK
1060 1070 1080 1090 1100
DAEINQRFKQ FENEYADFDQ AKKRELQELN QIRRNLEQSN ASLLKKRNQL
1110 1120 1130 1140 1150
TLDFALLRKV QHNTQTNRVQ LNTQIKEFLL EKKNFQKASD EAALQKALLI
1160 1170 1180 1190 1200
KRLRSFASKL QLQREALAIQ KLEFDKRDEQ QKSEINNAKL QLEQFKLEKQ
1210 1220 1230 1240 1250
NFDEAKQKQL IEFKDQCQRL DVEKRLLKQK LVQLKNLSKS YLTYKNRADL
1260 1270 1280 1290 1300
SQQQLQHKYA NLLELKEKLQ TAKRALDKKH RAIYGKMAQF VSELRQEKKQ
1310 1320 1330 1340 1350
LLSAQKQVDD KSRLLEQNQR HLQNLSSETK KKRQSLEHDI NKFDQRRKEA
1360 1370 1380 1390 1400
VSSILNSHKK LKQKEGELQG ILQKLSLKKT QIEQEFSKLY QQREKLDRQR
1410 1420 1430 1440 1450
TTLSKLHREL KAQNEATAHK NREVLEIENY YKKELQRLTT EKSEFDNNKN
1460 1470 1480 1490 1500
RLFEYFRKIR NEIEKKEAHI KTVLEETQKK RHLVETEAVK LHLQKQSIIS
1510 1520 1530 1540 1550
KGQELKEIKE RVSRDISHTN KQREELNSLL HQNKLLQKNL AEREREINNK
1560 1570 1580 1590 1600
DSLLTQKIQT AKQKLSEKEA RILKLLEKMR AVEQQYQAEI TRLKTRNADL
1610 1620 1630 1640 1650
EKNDNKHLFP PLFKINGNDM NYPYPYPWFY PQQKQEDSSN QIRHLFEQQL
1660 1670 1680 1690 1700
QFMQQRYENE LTELRRQRAL LEKKLDQIQL ESQLSAKKND FEKVEQMMQK
1710 1720 1730 1740 1750
LLEKTEQKLS AFDQKINALA EQINTQKAEH ADSEKQQLLL RIEQLEKQNL
1760 1770 1780 1790 1800
AQAVQTPQPV QPVVQAPAVV PQVIQPQVVQ SQPAFLATQQ SISKQQQIAQ
1810
LNAEINSIKK LIAQKAAK
Length:1,818
Mass (Da):215,622
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i66DF4B08F0FCFBC0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U00089 Genomic DNA Translation: AAB96174.1
U59896 Genomic DNA Translation: AAB52527.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S73852

NCBI Reference Sequences

More...
RefSeqi
NP_109998.1, NC_000912.1
WP_010874666.1, NC_000912.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAB96174; AAB96174; MPN_310

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
876917

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mpn:MPN310

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|272634.6.peg.334

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA Translation: AAB96174.1
U59896 Genomic DNA Translation: AAB52527.1
PIRiS73852
RefSeqiNP_109998.1, NC_000912.1
WP_010874666.1, NC_000912.1

3D structure databases

SMRiP75471
ModBaseiSearch...

Protein-protein interaction databases

IntActiP75471, 1 interactor

Proteomic databases

PRIDEiP75471

Genome annotation databases

EnsemblBacteriaiAAB96174; AAB96174; MPN_310
GeneIDi876917
KEGGimpn:MPN310
PATRICifig|272634.6.peg.334

Phylogenomic databases

HOGENOMiCLU_237675_0_0_14
OMAiYKDCVSR

Enzyme and pathway databases

BioCyciMPNE272634:G1GJ3-494-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR016430 Cytadherence_Hmw2
PIRSFiPIRSF004800 Hmw2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHMW2_MYCPN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P75471
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: February 26, 2020
This is version 91 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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