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Entry version 116 (02 Dec 2020)
Sequence version 2 (30 May 2000)
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Protein

Probable propionate kinase

Gene

pduW

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Was originally (Ref. 1) thought to be AckA.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:STM2057-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable propionate kinaseUniRule annotation (EC:2.7.2.15UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pduWUniRule annotation
Ordered Locus Names:STM2057
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri99287 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001014 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001076511 – 404Probable propionate kinaseAdd BLAST404

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P74879

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By propanediol.1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P74879

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the acetokinase family. PduW subfamily.UniRule annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020352_0_1_6

Identification of Orthologs from Complete Genome Data

More...
OMAi
PLPWRYY

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P74879

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_00020, Acetate_kinase, 1 hit
MF_01882, Propion_kin_subfam2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004372, Ac/propionate_kinase
IPR000890, Aliphatic_acid_kin_short-chain
IPR023865, Aliphatic_acid_kinase_CS
IPR043129, ATPase_NBD
IPR024896, Propionate_kinase_PduW

The PANTHER Classification System

More...
PANTHERi
PTHR21060, PTHR21060, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00871, Acetate_kinase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000722, Acetate_prop_kin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00471, ACETATEKNASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53067, SSF53067, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00016, ackA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01075, ACETATE_KINASE_1, 1 hit
PS01076, ACETATE_KINASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P74879-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYKIMAINA GSSSLKFQLL EMPQGDMLCQ GLIERIGMAD AQVTIKTHSQ
60 70 80 90 100
KWQETVPVAD HRDAVTLLLE KLLGYQIINS LRDIDGVGHR VAHGGEFFKD
110 120 130 140 150
STLVTDETLA QIERLAELAP LHNPVNALGI HVFRQLLPDA PSVAVFDTAF
160 170 180 190 200
HQTLDEPAYI YPLPWHYYAE LGIRRYGFHG TSHKYVSGVL AEKLGVPLSA
210 220 230 240 250
LRVICCHLGN GSSICAIKNG RSVNTSMGFT PQSGVMMGTR SGDIDPSILP
260 270 280 290 300
WIAQRESKTP QQLNQLLNNE SGLLGVSGVS SDYRDVEQAA NTGNRQAKLA
310 320 330 340 350
LTLFAERIRA TIGSYIMQMG GLDALVFTGG IGENSARARS AVCHNLQFLG
360 370 380 390 400
LAVDEEKNQR NATFIQTENA LVKVAVINTN EELMIAQDVM RIALPATEGL

CVPA
Length:404
Mass (Da):43,995
Last modified:May 30, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE236F981EAFBB304
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD39021 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti25G → R in AAB09552 (Ref. 1) Curated1
Sequence conflicti60 – 67DHRDAVTL → RSSRCVNW in AAB09552 (Ref. 1) Curated8
Sequence conflicti92A → R in AAB09552 (Ref. 1) Curated1
Sequence conflicti212S → T in AAB09552 (Ref. 1) Curated1
Sequence conflicti247 – 261SILPW…SKTPQ → HSAVDSPARNENAE in AAB09552 (Ref. 1) CuratedAdd BLAST15
Sequence conflicti300 – 309ALTLFAERIR → RSHSVCRTHS in AAB09552 (Ref. 1) Curated10
Sequence conflicti342 – 352VCHNLQFLGLA → CAIISIFGLS in AAB09552 (Ref. 1) CuratedAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U67435 Genomic DNA Translation: AAB09552.1
AF026270 Genomic DNA Translation: AAD39021.1 Different initiation.
AE006468 Genomic DNA Translation: AAL20961.1

NCBI Reference Sequences

More...
RefSeqi
NP_461002.1, NC_003197.2
WP_000120647.1, NC_003197.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAL20961; AAL20961; STM2057

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1253578

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
stm:STM2057

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|99287.12.peg.2179

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67435 Genomic DNA Translation: AAB09552.1
AF026270 Genomic DNA Translation: AAD39021.1 Different initiation.
AE006468 Genomic DNA Translation: AAL20961.1
RefSeqiNP_461002.1, NC_003197.2
WP_000120647.1, NC_003197.2

3D structure databases

SMRiP74879
ModBaseiSearch...

Proteomic databases

PaxDbiP74879

Genome annotation databases

EnsemblBacteriaiAAL20961; AAL20961; STM2057
GeneIDi1253578
KEGGistm:STM2057
PATRICifig|99287.12.peg.2179

Phylogenomic databases

HOGENOMiCLU_020352_0_1_6
OMAiPLPWRYY
PhylomeDBiP74879

Enzyme and pathway databases

BioCyciMetaCyc:STM2057-MONOMER

Family and domain databases

HAMAPiMF_00020, Acetate_kinase, 1 hit
MF_01882, Propion_kin_subfam2, 1 hit
InterProiView protein in InterPro
IPR004372, Ac/propionate_kinase
IPR000890, Aliphatic_acid_kin_short-chain
IPR023865, Aliphatic_acid_kinase_CS
IPR043129, ATPase_NBD
IPR024896, Propionate_kinase_PduW
PANTHERiPTHR21060, PTHR21060, 1 hit
PfamiView protein in Pfam
PF00871, Acetate_kinase, 1 hit
PIRSFiPIRSF000722, Acetate_prop_kin, 1 hit
PRINTSiPR00471, ACETATEKNASE
SUPFAMiSSF53067, SSF53067, 2 hits
TIGRFAMsiTIGR00016, ackA, 1 hit
PROSITEiView protein in PROSITE
PS01075, ACETATE_KINASE_1, 1 hit
PS01076, ACETATE_KINASE_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDUW_SALTY
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P74879
Secondary accession number(s): Q9XDM5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: December 2, 2020
This is version 116 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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