UniProtKB - P74750 (DPO3A_SYNY3)
DNA polymerase III subunit alpha
dnaE-N
moreFunctioni
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity).
By similarityMiscellaneous
Catalytic activityi
- EC:2.7.7.7
GO - Molecular functioni
- 3'-5' exonuclease activity Source: InterPro
- DNA-directed DNA polymerase activity Source: UniProtKB-KW
- nucleic acid binding Source: InterPro
GO - Biological processi
- DNA replication Source: UniProtKB-KW
- intein-mediated protein splicing Source: InterPro
Keywordsi
Molecular function | DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase |
Biological process | DNA replication |
Protein family/group databases
MEROPSi | N10.003 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:dnaE-N Ordered Locus Names:slr0603 AND Name:dnaE-C Ordered Locus Names:sll1572 |
Organismi | Synechocystis sp. (strain PCC 6803 / Kazusa) |
Taxonomic identifieri | 1111708 [NCBI] |
Taxonomic lineagei | Bacteria › Cyanobacteria › Synechococcales › Merismopediaceae › Synechocystis › unclassified Synechocystis › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000007364 | 1 – 774 | DNA polymerase III subunit alpha, 1st partAdd BLAST | 774 | |
ChainiPRO_0000007365 | 775 – 897 | Ssp dnaE intein, 1st partAdd BLAST | 123 | |
ChainiPRO_0000007366 | 898 – 933 | Ssp dnaE intein, 2nd partAdd BLAST | 36 | |
ChainiPRO_0000007367 | 934 – 1355 | DNA polymerase III subunit alpha, 2nd partAdd BLAST | 422 |
Post-translational modificationi
Keywords - PTMi
Autocatalytic cleavage, Protein splicingProteomic databases
PaxDbi | P74750 |
PRIDEi | P74750 |
Interactioni
Subunit structurei
DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the PolIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex (By similarity).
By similarityProtein-protein interaction databases
IntActi | P74750, 2 interactors |
STRINGi | 1148.1653960 |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P74750 |
SMRi | P74750 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P74750 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0587, Bacteria |
InParanoidi | P74750 |
PhylomeDBi | P74750 |
Family and domain databases
Gene3Di | 1.10.10.1600, 1 hit |
InterProi | View protein in InterPro IPR011708, DNA_pol3_alpha_NTPase_dom IPR041931, DNA_pol3_alpha_thumb_dom IPR040982, DNA_pol3_finger IPR029460, DNAPol_HHH IPR003587, Hint_dom_N IPR036844, Hint_dom_sf IPR030934, Intein_C IPR006141, Intein_N IPR004365, NA-bd_OB_tRNA IPR004013, PHP_dom IPR003141, Pol/His_phosphatase_N IPR016195, Pol/histidinol_Pase-like IPR004805, PolC_alpha |
PANTHERi | PTHR32294, PTHR32294, 1 hit |
Pfami | View protein in Pfam PF07733, DNA_pol3_alpha, 1 hit PF17657, DNA_pol3_finger, 1 hit PF14579, HHH_6, 1 hit PF02811, PHP, 1 hit PF01336, tRNA_anti-codon, 1 hit |
SMARTi | View protein in SMART SM00306, HintN, 1 hit SM00481, POLIIIAc, 1 hit |
SUPFAMi | SSF51294, SSF51294, 1 hit SSF89550, SSF89550, 1 hit |
TIGRFAMsi | TIGR01443, intein_Cterm, 1 hit TIGR01445, intein_Nterm, 1 hit TIGR00594, polc, 1 hit |
PROSITEi | View protein in PROSITE PS50818, INTEIN_C_TER, 1 hit PS50817, INTEIN_N_TER, 1 hit |
i Sequence
Sequence statusi: Fragments.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MSFVGLHIHS DYSLLDGASQ LPALIDRAIE LGMPAIALTD HGVMYGAVEL
60 70 80 90 100
LKVCRGKPIK PIIGNEMYVI NGDIEINKRH RRFHQVVLAK NNQGYRNLVK
110 120 130 140 150
LTTISNLKGI QGSGIFARPC INKELLEQYK EGLIVTSACL GGEVPQAILK
160 170 180 190 200
GDLDHARQVA KWYKNLFGDD YYLEIQDHGS VEDRLVNINL VKIAQELDIK
210 220 230 240 250
IVATNDSHFI SCNDVEAHDA LLCIQTGKLI TEEKRLRYSG TEYLKSAEEM
260 270 280 290 300
HLLFRDHLPD DIIETAIANT LEVADKVEAY SILGEPRIPH YPIPPNHTPE
310 320 330 340 350
TYVEDIAWDG LLERLKCRER ADITPVYKER LEYELRMLEK MGFCTYFLVV
360 370 380 390 400
WDYIKYARDH GIPVGPGRGS AAGSLVAYCM KITNIDPVHH GLIFERFLNP
410 420 430 440 450
ERKSMPDVDT DFCIDRRDEM IEYVTQKYGE DKVAQIITFN RMTSKAVLKD
460 470 480 490 500
VARVLDIPYA ESDKMAKMIP VSRGKPAKLK VMISDQTPEP QFKARYDNEP
510 520 530 540 550
WVKKWIDMAI RIEGTNKTFG VHAAGVVISS EPLDQIVPLQ KNNDGAVITQ
560 570 580 590 600
YYMEDVEAMG LLKMDFLGLK NLTTLQRAVE LVAETKGIEL DLDDLPLQER
610 620 630 640 650
KALQIRARTG SKKLPDDVKK THKLLEAGDL EGIFQLESQG MKQIVRDLKP
660 670 680 690 700
SGIEDISSIL ALYRPGPLDA GLIPIFINRK HGREEISYQH KLLEPILNET
710 720 730 740 750
YGVLVYQEQI MKMAQDLADY SLGEADLLRR AMGKKKAEEM QKHRAKFVDG
760 770 780 790 800
STKHGVPSRI AENLFDQMVK FAEYCLSFGT EILTVEYGPL PIGKIVSEEI
810 820 830 840 850
NCSVYSVDPE GRVYTQAIAQ WHDRGEQEVL EYELEDGSVI RATSDHRFLT
860 870 880 890 900
TDYQLLAIEE IFARQLDLLT LENIKQTEEA LDNHRLPFPL LDAGTIKMVK
910 920 930 940 950
VIGRRSLGVQ RIFDIGLPQD HNFLLANGAI AANCFNKSHS TAYAYVTYQT
960 970 980 990 1000
AYLKANYPVE YMAALLTASS DSQEKVEKYR ENCQKMGITV EPPDINRSQR
1010 1020 1030 1040 1050
HFTPLGEAIL FGLSAVRNLG EGAIEQIITA RDNSEEKRFK SLADFCTQVD
1060 1070 1080 1090 1100
LRVVNRRAIE TLIMAGAFDG VQSNRNQLLH DLELVIAWAQ KRAKEKETGQ
1110 1120 1130 1140 1150
LNIFDSLTAG ESIKAKEAAN NGFEQEPSAP PVAEFSLQEK LQLEKEHLGF
1160 1170 1180 1190 1200
YVSEHPLKSV QRSARLLSPI NLVDLDQYKV RQKVSAVAIL VAVKKIITKK
1210 1220 1230 1240 1250
NGQPMAFLTL EDMSGQSEAV VFPSNYERLQ DVLIEGSQQM IWGKVDRRDD
1260 1270 1280 1290 1300
QYQLIVEDLE PVEEVKMVML DLTPQEIANT STQARLKQIL QSHAPQKEQM
1310 1320 1330 1340 1350
KIPVVACINE GPTKHFIRFG ENYWVNDYGT AVASLQELGF RARLEPLLPQ
SQSVG
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-adjacent residuesi | 897 – 898 | Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BA000022 Genomic DNA Translation: BAA18870.1 Sequence problems. BA000022 Genomic DNA Translation: BAA17242.1 Sequence problems. |
PIRi | A59016 S75328 S76958 |
Genome annotation databases
EnsemblBacteriai | BAA17242; BAA17242; BAA17242 BAA18870; BAA18870; BAA18870 |
KEGGi | syn:sll1572 syn:slr0603 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BA000022 Genomic DNA Translation: BAA18870.1 Sequence problems. BA000022 Genomic DNA Translation: BAA17242.1 Sequence problems. |
PIRi | A59016 S75328 S76958 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1ZD7 | X-ray | 1.70 | A/B | 775-933 | [»] | |
1ZDE | X-ray | 1.95 | A | 770-936 | [»] | |
3NZM | X-ray | 1.55 | A | 772-933 | [»] | |
4GIG | X-ray | 1.80 | A | 775-933 | [»] | |
5OL1 | X-ray | 1.75 | A | 776-889 | [»] | |
5OL5 | X-ray | 2.33 | A/B/C/D | 776-931 | [»] | |
AlphaFoldDBi | P74750 | |||||
SMRi | P74750 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P74750, 2 interactors |
STRINGi | 1148.1653960 |
Protein family/group databases
MEROPSi | N10.003 |
Proteomic databases
PaxDbi | P74750 |
PRIDEi | P74750 |
Genome annotation databases
EnsemblBacteriai | BAA17242; BAA17242; BAA17242 BAA18870; BAA18870; BAA18870 |
KEGGi | syn:sll1572 syn:slr0603 |
Phylogenomic databases
eggNOGi | COG0587, Bacteria |
InParanoidi | P74750 |
PhylomeDBi | P74750 |
Miscellaneous databases
EvolutionaryTracei | P74750 |
Family and domain databases
Gene3Di | 1.10.10.1600, 1 hit |
InterProi | View protein in InterPro IPR011708, DNA_pol3_alpha_NTPase_dom IPR041931, DNA_pol3_alpha_thumb_dom IPR040982, DNA_pol3_finger IPR029460, DNAPol_HHH IPR003587, Hint_dom_N IPR036844, Hint_dom_sf IPR030934, Intein_C IPR006141, Intein_N IPR004365, NA-bd_OB_tRNA IPR004013, PHP_dom IPR003141, Pol/His_phosphatase_N IPR016195, Pol/histidinol_Pase-like IPR004805, PolC_alpha |
PANTHERi | PTHR32294, PTHR32294, 1 hit |
Pfami | View protein in Pfam PF07733, DNA_pol3_alpha, 1 hit PF17657, DNA_pol3_finger, 1 hit PF14579, HHH_6, 1 hit PF02811, PHP, 1 hit PF01336, tRNA_anti-codon, 1 hit |
SMARTi | View protein in SMART SM00306, HintN, 1 hit SM00481, POLIIIAc, 1 hit |
SUPFAMi | SSF51294, SSF51294, 1 hit SSF89550, SSF89550, 1 hit |
TIGRFAMsi | TIGR01443, intein_Cterm, 1 hit TIGR01445, intein_Nterm, 1 hit TIGR00594, polc, 1 hit |
PROSITEi | View protein in PROSITE PS50818, INTEIN_C_TER, 1 hit PS50817, INTEIN_N_TER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DPO3A_SYNY3 | |
Accessioni | P74750Primary (citable) accession number: P74750 Secondary accession number(s): P73215 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | September 26, 2001 | |
Last modified: | May 25, 2022 | |
This is version 154 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Intein-containing proteins
List of intein-containing protein entries - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families