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UniProtKB - P74576 (SPEA1_SYNY3)
Protein
Biosynthetic arginine decarboxylase 1
Gene
speA1
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Functioni
Catalyzes the biosynthesis of agmatine from arginine.
By similarityCatalytic activityi
- EC:4.1.1.19
Cofactori
Protein has several cofactor binding sites:- Mg2+By similarity
- pyridoxal 5'-phosphateBy similarity
GO - Molecular functioni
- arginine decarboxylase activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- arginine catabolic process Source: InterPro
- putrescine biosynthetic process from arginine Source: GO_Central
- spermidine biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Decarboxylase, Lyase |
Biological process | Polyamine biosynthesis, Spermidine biosynthesis |
Ligand | Magnesium, Metal-binding, Pyridoxal phosphate |
Enzyme and pathway databases
BRENDAi | 4.1.1.19, 382 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:speA1 Synonyms:speA Ordered Locus Names:slr0662 |
Organismi | Synechocystis sp. (strain PCC 6803 / Kazusa) |
Taxonomic identifieri | 1111708 [NCBI] |
Taxonomic lineagei | Bacteria › Cyanobacteria › Synechococcales › Merismopediaceae › Synechocystis › unclassified Synechocystis › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000149981 | 1 – 695 | Biosynthetic arginine decarboxylase 1Add BLAST | 695 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 141 | N6-(pyridoxal phosphate)lysineBy similarity | 1 |
Proteomic databases
PaxDbi | P74576 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 332 – 342 | Substrate-bindingSequence analysisAdd BLAST | 11 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG1166, Bacteria |
InParanoidi | P74576 |
OMAi | AVEYTQH |
PhylomeDBi | P74576 |
Family and domain databases
CDDi | cd06830, PLPDE_III_ADC, 1 hit |
Gene3Di | 2.40.37.10, 1 hit 3.20.20.10, 1 hit |
HAMAPi | MF_01417, SpeA, 1 hit |
InterProi | View protein in InterPro IPR009006, Ala_racemase/Decarboxylase_C IPR040634, Arg_decarb_HB IPR041128, Arg_decarbox_C IPR002985, Arg_decrbxlase IPR022657, De-COase2_CS IPR022644, De-COase2_N IPR022653, De-COase2_pyr-phos_BS IPR000183, Orn/DAP/Arg_de-COase IPR029066, PLP-binding_barrel |
PANTHERi | PTHR43295, PTHR43295, 1 hit |
Pfami | View protein in Pfam PF17810, Arg_decarb_HB, 1 hit PF17944, Arg_decarbox_C, 1 hit PF02784, Orn_Arg_deC_N, 1 hit |
PIRSFi | PIRSF001336, Arg_decrbxlase, 1 hit |
PRINTSi | PR01180, ARGDCRBXLASE PR01179, ODADCRBXLASE |
SUPFAMi | SSF50621, SSF50621, 1 hit SSF51419, SSF51419, 1 hit |
TIGRFAMsi | TIGR01273, speA, 1 hit |
PROSITEi | View protein in PROSITE PS00878, ODR_DC_2_1, 1 hit PS00879, ODR_DC_2_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P74576-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEGQSIELEL SVMAMPELID STEAGHTAGV KTDSNPQAIA QDRRWTIDDS
60 70 80 90 100
ENLYRITGWG EPYFSINAAG HVTVSPQADH GGALDLYELV KGLRQRNIGL
110 120 130 140 150
PLLLRFSDIL ADRINRLNAA FARGIARYRY PNTYRGVYPI KCNQHRHIVE
160 170 180 190 200
SLVRYGTPYN FGLEAGSKPE LMIALAMLQP QENPEPDQQN QPLLICNGYK
210 220 230 240 250
DREYIETALL ARRLGHRPII VVEQVAEVAL AIEISSNLGI KPILGVRAKL
260 270 280 290 300
STQGMGRWGI STGDRAKFGL TIPEMLTAIE QLRRADMLDS LQLLHFHIGS
310 320 330 340 350
QISSISVIKE AMTEASQIFV QLAKLGANMR YLDVGGGLGV DYDGSKTNFY
360 370 380 390 400
ASKNYNIQNY VNDVISAVQD ACVAAEVPCP VLISESGRAI ASHQSVLIFD
410 420 430 440 450
VVATNDINPP LPKVKGKDHA ILRNLMETWE TITVDNYQEA YHDVEQFKTE
460 470 480 490 500
AISLFNFGYL GLKERAKAEE LYWACCRKIL QICRQQEYVP DDLENLEVNL
510 520 530 540 550
ASIYYANMSV FQSAPDSWAI DQLFPIMPIH RLDEEPTQRG ILADITCDSD
560 570 580 590 600
GKIDQFIDLR DVKSVLELHP LIEVHQPGTP PRVEPYYLGM FLVGAYQEIM
610 620 630 640 650
GNLHNLFGDI NVVHIQMNPK GYQIEHLVRG DTIAEVLGYV QYDPEDLLEN
660 670 680 690
MRRYCEQAME DKRMSLEEAQ LLLENYERSL LQYTYLKPTS GIHTS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BA000022 Genomic DNA Translation: BAA18683.1 |
PIRi | S76771 |
Genome annotation databases
EnsemblBacteriai | BAA18683; BAA18683; BAA18683 |
KEGGi | syn:slr0662 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BA000022 Genomic DNA Translation: BAA18683.1 |
PIRi | S76771 |
3D structure databases
SMRi | P74576 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P74576, 2 interactors |
STRINGi | 1148.1653772 |
Proteomic databases
PaxDbi | P74576 |
Genome annotation databases
EnsemblBacteriai | BAA18683; BAA18683; BAA18683 |
KEGGi | syn:slr0662 |
Phylogenomic databases
eggNOGi | COG1166, Bacteria |
InParanoidi | P74576 |
OMAi | AVEYTQH |
PhylomeDBi | P74576 |
Enzyme and pathway databases
BRENDAi | 4.1.1.19, 382 |
Family and domain databases
CDDi | cd06830, PLPDE_III_ADC, 1 hit |
Gene3Di | 2.40.37.10, 1 hit 3.20.20.10, 1 hit |
HAMAPi | MF_01417, SpeA, 1 hit |
InterProi | View protein in InterPro IPR009006, Ala_racemase/Decarboxylase_C IPR040634, Arg_decarb_HB IPR041128, Arg_decarbox_C IPR002985, Arg_decrbxlase IPR022657, De-COase2_CS IPR022644, De-COase2_N IPR022653, De-COase2_pyr-phos_BS IPR000183, Orn/DAP/Arg_de-COase IPR029066, PLP-binding_barrel |
PANTHERi | PTHR43295, PTHR43295, 1 hit |
Pfami | View protein in Pfam PF17810, Arg_decarb_HB, 1 hit PF17944, Arg_decarbox_C, 1 hit PF02784, Orn_Arg_deC_N, 1 hit |
PIRSFi | PIRSF001336, Arg_decrbxlase, 1 hit |
PRINTSi | PR01180, ARGDCRBXLASE PR01179, ODADCRBXLASE |
SUPFAMi | SSF50621, SSF50621, 1 hit SSF51419, SSF51419, 1 hit |
TIGRFAMsi | TIGR01273, speA, 1 hit |
PROSITEi | View protein in PROSITE PS00878, ODR_DC_2_1, 1 hit PS00879, ODR_DC_2_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SPEA1_SYNY3 | |
Accessioni | P74576Primary (citable) accession number: P74576 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 14, 2001 |
Last sequence update: | February 1, 1997 | |
Last modified: | September 29, 2021 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families