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Protein

RNA polymerase sigma factor SigA

Gene

sigA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi386 – 405H-T-H motifUniRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Sigma factor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase sigma factor SigAUniRule annotation
Gene namesi
Name:sigAUniRule annotation
Synonyms:rpoD, rpoD1
Ordered Locus Names:slr0653
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000939281 – 425RNA polymerase sigma factor SigAAdd BLAST425

Proteomic databases

PaxDbiP74565
PRIDEiP74565

Interactioni

Subunit structurei

Interacts transiently with the RNA polymerase catalytic core.UniRule annotation

Protein-protein interaction databases

IntActiP74565, 42 interactors
STRINGi1148.SYNGTS_2968

Structurei

3D structure databases

ProteinModelPortaliP74565
SMRiP74565
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni193 – 263Sigma-70 factor domain-2UniRule annotationAdd BLAST71
Regioni272 – 347Sigma-70 factor domain-3UniRule annotationAdd BLAST76
Regioni360 – 413Sigma-70 factor domain-4UniRule annotationAdd BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi217 – 220Interaction with polymerase core subunit RpoC4

Sequence similaritiesi

Belongs to the sigma-70 factor family. RpoD/SigA subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000270273
InParanoidiP74565
KOiK03086
OMAiIRVYLQE
PhylomeDBiP74565

Family and domain databases

Gene3Di1.10.10.10, 2 hits
HAMAPiMF_00963 Sigma70_RpoD_SigA, 1 hit
InterProiView protein in InterPro
IPR014284 RNA_pol_sigma-70_dom
IPR000943 RNA_pol_sigma70
IPR009042 RNA_pol_sigma70_r1_2
IPR007627 RNA_pol_sigma70_r2
IPR007624 RNA_pol_sigma70_r3
IPR007630 RNA_pol_sigma70_r4
IPR013325 RNA_pol_sigma_r2
IPR013324 RNA_pol_sigma_r3/r4-like
IPR012760 RNA_pol_sigma_RpoD_C
IPR017848 RNA_pol_sigma_RpoD_cyanobac
IPR028630 Sigma70_RpoD
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00140 Sigma70_r1_2, 1 hit
PF04542 Sigma70_r2, 1 hit
PF04539 Sigma70_r3, 1 hit
PF04545 Sigma70_r4, 1 hit
PRINTSiPR00046 SIGMA70FCT
SUPFAMiSSF88659 SSF88659, 2 hits
SSF88946 SSF88946, 1 hit
TIGRFAMsiTIGR02393 RpoD_Cterm, 1 hit
TIGR02997 Sig70-cyanoRpoD, 1 hit
TIGR02937 sigma70-ECF, 1 hit
PROSITEiView protein in PROSITE
PS00715 SIGMA70_1, 1 hit
PS00716 SIGMA70_2, 1 hit

Sequencei

Sequence statusi: Complete.

P74565-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTQTKEPLTK AESAELEQEI ELSQYINTDD IDDDDIDVED LEQEVAATEG
60 70 80 90 100
KEKKVRKIRK DAVKKKPYTE DSIRIYLQEI GRIRLLRAEE EIELARQIAD
110 120 130 140 150
LLELELIRDN LTLQLERQPS ELEWGKQVWK LETAKQRLVG DKKKEPKKKD
160 170 180 190 200
IDSYLANPDN ELSLENEWSQ QPNKNFAAFR RRLFLDRRAK DKMVQSNLRL
210 220 230 240 250
VVSIAKKYMN RGLSFQDLIQ EGSLGLIRAA EKFDHEKGYK FSTYATWWIR
260 270 280 290 300
QAITRAIADQ SRTIRLPVHL YETISRIKKT TKLLSQEMRR KPTEEEIAEK
310 320 330 340 350
MEMTIEKLRF IAKSAQLPIS LETPIGKEED SRLGDFIEAD GETPEDEVSK
360 370 380 390 400
NLLREDLENV LDTLSPRERD VLRLRYGLDD GRMKTLEEIG QIFNVTRERI
410 420
RQIEAKALRK LRHPNRNSIL KEYIR
Length:425
Mass (Da):49,936
Last modified:February 1, 1997 - v1
Checksum:i4043FEA859B442D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA18672.1
D86213 Genomic DNA Translation: BAA13043.1
PIRiS76760

Genome annotation databases

EnsemblBacteriaiBAA18672; BAA18672; BAA18672
KEGGisyn:slr0653

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA18672.1
D86213 Genomic DNA Translation: BAA13043.1
PIRiS76760

3D structure databases

ProteinModelPortaliP74565
SMRiP74565
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP74565, 42 interactors
STRINGi1148.SYNGTS_2968

Proteomic databases

PaxDbiP74565
PRIDEiP74565

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA18672; BAA18672; BAA18672
KEGGisyn:slr0653

Phylogenomic databases

HOGENOMiHOG000270273
InParanoidiP74565
KOiK03086
OMAiIRVYLQE
PhylomeDBiP74565

Family and domain databases

Gene3Di1.10.10.10, 2 hits
HAMAPiMF_00963 Sigma70_RpoD_SigA, 1 hit
InterProiView protein in InterPro
IPR014284 RNA_pol_sigma-70_dom
IPR000943 RNA_pol_sigma70
IPR009042 RNA_pol_sigma70_r1_2
IPR007627 RNA_pol_sigma70_r2
IPR007624 RNA_pol_sigma70_r3
IPR007630 RNA_pol_sigma70_r4
IPR013325 RNA_pol_sigma_r2
IPR013324 RNA_pol_sigma_r3/r4-like
IPR012760 RNA_pol_sigma_RpoD_C
IPR017848 RNA_pol_sigma_RpoD_cyanobac
IPR028630 Sigma70_RpoD
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00140 Sigma70_r1_2, 1 hit
PF04542 Sigma70_r2, 1 hit
PF04539 Sigma70_r3, 1 hit
PF04545 Sigma70_r4, 1 hit
PRINTSiPR00046 SIGMA70FCT
SUPFAMiSSF88659 SSF88659, 2 hits
SSF88946 SSF88946, 1 hit
TIGRFAMsiTIGR02393 RpoD_Cterm, 1 hit
TIGR02997 Sig70-cyanoRpoD, 1 hit
TIGR02937 sigma70-ECF, 1 hit
PROSITEiView protein in PROSITE
PS00715 SIGMA70_1, 1 hit
PS00716 SIGMA70_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSIGA_SYNY3
AccessioniPrimary (citable) accession number: P74565
Secondary accession number(s): Q55351
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: February 1, 1997
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names
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Main funding by: National Institutes of Health

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