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Protein

Fructose-bisphosphate aldolase class 1

Gene

fda

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase 2 (pfkA2), ATP-dependent 6-phosphofructokinase 1 (pfkA1)
  4. Fructose-bisphosphate aldolase class 1 (fda), Fructose-bisphosphate aldolase class 2 (fbaA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei181Proton acceptorBy similarity1
Active sitei218Schiff-base intermediate with dihydroxyacetone-PBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandSchiff base

Enzyme and pathway databases

SABIO-RKiP74309
UniPathwayiUPA00109; UER00183

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase class 1 (EC:4.1.2.13)
Alternative name(s):
Fructose-bisphosphate aldolase class I
Short name:
FBP aldolase
Gene namesi
Name:fda
Synonyms:fbaB
Ordered Locus Names:slr0943
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002169131 – 300Fructose-bisphosphate aldolase class 1Add BLAST300

Proteomic databases

PaxDbiP74309
PRIDEiP74309

Interactioni

Protein-protein interaction databases

IntActiP74309, 1 interactor
STRINGi1148.SYNGTS_1829

Structurei

3D structure databases

ProteinModelPortaliP74309
SMRiP74309
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000073502
InParanoidiP74309
KOiK01623
PhylomeDBiP74309

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00729 FBP_aldolase_1, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR000741 FBA_I
IPR023014 FBA_I_Gram+-type
PfamiView protein in Pfam
PF00274 Glycolytic, 1 hit

Sequencei

Sequence statusi: Complete.

P74309-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTLEPNQEQ LKKMKSHPGF IAALDQSGGS TPGALADYGI EPNTYSGDDQ
60 70 80 90 100
MFALVHQMRT RIMTSPGFTG DRILAAILFE DTMNREVDGE PTANYLWQNK
110 120 130 140 150
QIVPILKVDK GLAQEKDGSQ LMKPIPQLDS LLMKAKKKGI FGTKMRSFIK
160 170 180 190 200
HANPAGIEAI VDQQFELAQQ IIAAGLVPII EPEVDIHCSE KAQAEALLKQ
210 220 230 240 250
AMLKHLNQLP KGQWVMLKLT LPEQDNLYSN CIEHANVLRV VALSGGYSQA
260 270 280 290 300
EANERLSRNH GVIASFSRAL TEGLTAQQTD AEFNTMLDES IEKIYQASIT
Length:300
Mass (Da):33,149
Last modified:February 1, 1997 - v1
Checksum:iEDAE4D24F58FE667
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA18403.1
PIRiS76144

Genome annotation databases

EnsemblBacteriaiBAA18403; BAA18403; BAA18403
KEGGisyn:slr0943

Similar proteinsi

Entry informationi

Entry nameiALF1_SYNY3
AccessioniPrimary (citable) accession number: P74309
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

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