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Entry version 134 (29 Sep 2021)
Sequence version 1 (01 Feb 1997)
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Protein
Submitted name:

Delta-1-pyrroline-5-carboxylate dehydrogenase

Gene

putA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei749UniRule annotation1
Active sitei783UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Delta-1-pyrroline-5-carboxylate dehydrogenaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:putAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1111708 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystisunclassified Synechocystis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001425 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P74275

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
1148.1653455

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P74275

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 127PutA_NInterPro annotationAdd BLAST116
Domaini136 – 442Pro_dhInterPro annotationAdd BLAST307
Domaini514 – 973AldedhInterPro annotationAdd BLAST460

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0506, Bacteria
COG1012, Bacteria

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P74275

Identification of Orthologs from Complete Genome Data

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OMAi
PPWNFPV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P74275

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07124, ALDH_PutA-P5CDH-RocA, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.309.10, 1 hit
3.40.605.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016161, Ald_DH/histidinol_DH
IPR016163, Ald_DH_C
IPR016160, Ald_DH_CS_CYS
IPR029510, Ald_DH_CS_GLU
IPR016162, Ald_DH_N
IPR015590, Aldehyde_DH_dom
IPR025703, Bifunct_PutA
IPR029041, FAD-linked_oxidoreductase-like
IPR002872, Proline_DH_dom
IPR041514, PutA_N
IPR005932, RocA

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00171, Aldedh, 1 hit
PF01619, Pro_dh, 1 hit
PF18083, PutA_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000197, Bifunct_PutA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51730, SSF51730, 1 hit
SSF53720, SSF53720, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01237, D1pyr5carbox2, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P74275-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVAQIDSQQQ YEQATQAIAK ELLAQTREKR SLWDKIGDNL RLDDKLLDWT
60 70 80 90 100
MGHPGLRVQL FKFIDCLPAL QSNSEIANHL QQYMSEEEVE LPEALKKLLN
110 120 130 140 150
FADAHSTPAQ IAAGTVSKAT EQLAFKYIAG ETIAQVIKTV ERLRKEKMGF
160 170 180 190 200
TIDLLGEAVI TESEAAEYWQ NYLDLMAQLS QQAKSWSKVP QIDQADGEIL
210 220 230 240 250
PQVQVSVKLT AFYSQFDPLD PAGSKAKVCE RIRELLRRAQ ELGVAVHFDM
260 270 280 290 300
EQYHYKDLIL NILKELLVEE EFRSRTDVGI TMQAYLRDST EDLEALIPWA
310 320 330 340 350
KHRGYPVTVR LVKGAYWDQE TIKAQQNHWQ IPVYVEKAQT DANYERMTRL
360 370 380 390 400
LLENHEYLYA AIGSHNVRSQ ALACAIAEEL NIPKRRYEMQ ILYGMGEPLA
410 420 430 440 450
RAIVKRGHRV RVYAPYGRLL PGMAYLIRRL LENTANSSFL RQNLEERPIE
460 470 480 490 500
ELIAPPQVKG INDLPTKGYG NAPDTDYADA DLRQQAFQAL TRVKQQLGKT
510 520 530 540 550
YLPYINGEYV ETANYIDSVN PCRPSQAIGK VGLISVEQAD HALEIAKAAF
560 570 580 590 600
PAWKKTPVRE RCGILRKAAD IMEERRHELN AWICLEVGKI IPQADAEVSE
610 620 630 640 650
AIDFCRYYAD EMERLDQGVN LDIPGETNRY FYQPRGIALV ISPWNFPMAI
660 670 680 690 700
AVGMTVAALV TGNCTLLKPA ETSTVIAAKI AEILIAAGVP PGVFQYVPGK
710 720 730 740 750
GSVVGSHMVN HPDVHLIAFT GSREVGCRIY ADAALVQPGQ KHLKRVIAEM
760 770 780 790 800
GGKNAIIVDE SADLDQAVAG AVYSAFGYTG QKCSACSRVV VLSPVHDAFV
810 820 830 840 850
ERFVEATRSL NVGPTDDPST QVGPVIDAKA QARIQEYIEQ GKAECELAIA
860 870 880 890 900
CDAPSEGYFV GPTVFKNVDR HATIAQEEIF GPVVTIIRAA NFDEALEIAN
910 920 930 940 950
GTDYALTGGL YSRTPDHINR AAAEFEVGNL YINRTITGAI VSRQPFGGFK
960 970 980 990
MSGVGSKAGG PDYLLQFLEP RHVTENIQRQ GFAPIEGADQ
Length:990
Mass (Da):110,028
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE5F21B64C1293D79
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA18369.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S75910

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
BAA18369; BAA18369; BAA18369

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
syn:sll1561

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA18369.1
PIRiS75910

3D structure databases

SMRiP74275
ModBaseiSearch...

Protein-protein interaction databases

STRINGi1148.1653455

Proteomic databases

PaxDbiP74275

Genome annotation databases

EnsemblBacteriaiBAA18369; BAA18369; BAA18369
KEGGisyn:sll1561

Phylogenomic databases

eggNOGiCOG0506, Bacteria
COG1012, Bacteria
InParanoidiP74275
OMAiPPWNFPV
PhylomeDBiP74275

Family and domain databases

CDDicd07124, ALDH_PutA-P5CDH-RocA, 1 hit
Gene3Di3.40.309.10, 1 hit
3.40.605.10, 1 hit
InterProiView protein in InterPro
IPR016161, Ald_DH/histidinol_DH
IPR016163, Ald_DH_C
IPR016160, Ald_DH_CS_CYS
IPR029510, Ald_DH_CS_GLU
IPR016162, Ald_DH_N
IPR015590, Aldehyde_DH_dom
IPR025703, Bifunct_PutA
IPR029041, FAD-linked_oxidoreductase-like
IPR002872, Proline_DH_dom
IPR041514, PutA_N
IPR005932, RocA
PfamiView protein in Pfam
PF00171, Aldedh, 1 hit
PF01619, Pro_dh, 1 hit
PF18083, PutA_N, 1 hit
PIRSFiPIRSF000197, Bifunct_PutA, 1 hit
SUPFAMiSSF51730, SSF51730, 1 hit
SSF53720, SSF53720, 1 hit
TIGRFAMsiTIGR01237, D1pyr5carbox2, 1 hit
PROSITEiView protein in PROSITE
PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP74275_SYNY3
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P74275
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: September 29, 2021
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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