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Entry version 137 (12 Aug 2020)
Sequence version 1 (01 Feb 1997)
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Protein

Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase

Gene

spoT

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the degradation of ppGpp into GDP. It may also be capable of catalyzing the synthesis of ppGpp (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: ppGpp biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes ppGpp from GDP.
Proteins known to be involved in this subpathway in this organism are:
  1. Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (spoT)
This subpathway is part of the pathway ppGpp biosynthesis, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes ppGpp from GDP, the pathway ppGpp biosynthesis and in Purine metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandManganese

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00908;UER00886

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC:3.1.7.2)
Alternative name(s):
Penta-phosphate guanosine-3'-pyrophosphohydrolase
Short name:
(ppGpp)ase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:spoT
Ordered Locus Names:slr1325
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1111708 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystisunclassified Synechocystis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001425 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001665761 – 760Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolaseAdd BLAST760

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P74007

PRoteomics IDEntifications database

More...
PRIDEi
P74007

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P74007, 3 interactors

STRING: functional protein association networks

More...
STRINGi
1148.1653162

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini76 – 175HDPROSITE-ProRule annotationAdd BLAST100
Domaini421 – 482TGSPROSITE-ProRule annotationAdd BLAST62
Domaini685 – 759ACTPROSITE-ProRule annotationAdd BLAST75

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RelA/SpoT family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0317, Bacteria

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P74007

KEGG Orthology (KO)

More...
KOi
K01139

Identification of Orthologs from Complete Genome Data

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OMAi
HYYSIYQ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P74007

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00077, HDc, 1 hit
cd05399, NT_Rel-Spo_like, 1 hit
cd01668, TGS_RSH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.20.30, 1 hit
3.30.460.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002912, ACT_dom
IPR012675, Beta-grasp_dom_sf
IPR003607, HD/PDEase_dom
IPR043519, NT_sf
IPR004811, RelA/Spo_fam
IPR007685, RelA_SpoT
IPR004095, TGS
IPR012676, TGS-like
IPR033655, TGS_RelA

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13291, ACT_4, 1 hit
PF04607, RelA_SpoT, 1 hit
PF02824, TGS, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00471, HDc, 1 hit
SM00954, RelA_SpoT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81271, SSF81271, 1 hit
SSF81301, SSF81301, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00691, spoT_relA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51671, ACT, 1 hit
PS51831, HD, 1 hit
PS51880, TGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P74007-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNAVAALPTP TIHTTCAQDI HDIELPQWLE DCLQQWQREI EQGQDETTAP
60 70 80 90 100
HCLICRAFCF AYDLHAQQRR KSGEPYIAHP VAVAGLLRDL GGDEAMIAAG
110 120 130 140 150
FLHDVVEDTD ISIEQIEALF GEETASLVEG VTKLSKFNFS STTEHQAENF
160 170 180 190 200
RRMFLAMAKD IRVIVVKLAD RLHNMRTLDA LSPEKQRRIA RETKDIFAPL
210 220 230 240 250
ANRLGIWRFK WELEDLSFKY LEPDSYRKIQ SLVVEKRGDR ESRLETVKDM
260 270 280 290 300
LRFRLRDEGI EHFELQGRPK HLYGIYYKMT SQDKAFEEIY DIAALRIIVE
310 320 330 340 350
SKGECYRALS VVHDVFKPIP GRFKDYIGLP KPNRYQSLHT TVLGLTSRPL
360 370 380 390 400
EIQIRTEEMH HVAEYGIAAH WKYKESGGSE NATLTSTDEK FTWLRQLLDW
410 420 430 440 450
QSDLKDAQEY VENLKQNLFD DDVYVFTPKG EVISLARGAT PVDFAYRIHT
460 470 480 490 500
EVGHHMKGAR VNGQWLGVDT RLKNGDIVEI VTQKNSHPSL DWLNFVVTPS
510 520 530 540 550
ARHRIRQWFK RSRRDENILR GRELLEKELG KTGLEALLKS EPMQKTAERC
560 570 580 590 600
NYQNVEDLLA GLGYGEITSN SVVNRLRENN VNNVKNSQSS QEVTLASSPQ
610 620 630 640 650
VHPPTPPATG KDNSPIAGIE GLLYHIAGCC HPLPGEPIMG VVTRGARGIS
660 670 680 690 700
IHRQGCHNLE QMDGDRLIPV RWNPNTNNHQ TYPVDIVIEA IDRVGVLKDI
710 720 730 740 750
LSRLSDNHIN VRNADVKTHL GRPAIISLKI DIHDYQQLLG IMAKIKNMSD
760
VMDLRRVISG
Length:760
Mass (Da):86,569
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA276EA2286358F7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA18078.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S75517

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
BAA18078; BAA18078; BAA18078

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
syn:slr1325

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA18078.1
PIRiS75517

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiP74007, 3 interactors
STRINGi1148.1653162

Proteomic databases

PaxDbiP74007
PRIDEiP74007

Genome annotation databases

EnsemblBacteriaiBAA18078; BAA18078; BAA18078
KEGGisyn:slr1325

Phylogenomic databases

eggNOGiCOG0317, Bacteria
InParanoidiP74007
KOiK01139
OMAiHYYSIYQ
PhylomeDBiP74007

Enzyme and pathway databases

UniPathwayiUPA00908;UER00886

Family and domain databases

CDDicd00077, HDc, 1 hit
cd05399, NT_Rel-Spo_like, 1 hit
cd01668, TGS_RSH, 1 hit
Gene3Di3.10.20.30, 1 hit
3.30.460.10, 1 hit
InterProiView protein in InterPro
IPR002912, ACT_dom
IPR012675, Beta-grasp_dom_sf
IPR003607, HD/PDEase_dom
IPR043519, NT_sf
IPR004811, RelA/Spo_fam
IPR007685, RelA_SpoT
IPR004095, TGS
IPR012676, TGS-like
IPR033655, TGS_RelA
PfamiView protein in Pfam
PF13291, ACT_4, 1 hit
PF04607, RelA_SpoT, 1 hit
PF02824, TGS, 1 hit
SMARTiView protein in SMART
SM00471, HDc, 1 hit
SM00954, RelA_SpoT, 1 hit
SUPFAMiSSF81271, SSF81271, 1 hit
SSF81301, SSF81301, 1 hit
TIGRFAMsiTIGR00691, spoT_relA, 1 hit
PROSITEiView protein in PROSITE
PS51671, ACT, 1 hit
PS51831, HD, 1 hit
PS51880, TGS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPOT_SYNY3
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P74007
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: August 12, 2020
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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