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Protein

Histidinol-phosphate aminotransferase

Gene

hisC

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.

Cofactori

Pathwayi: L-histidine biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase regulatory subunit (hisZ), ATP phosphoribosyltransferase (hisG)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Putative histidinol dehydrogenase 2 (hisD2), Histidinol dehydrogenase 1 (hisD1)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00031; UER00012

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol-phosphate aminotransferase (EC:2.6.1.9)
Alternative name(s):
Imidazole acetol-phosphate transaminase
Gene namesi
Name:hisC
Ordered Locus Names:sll1958
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001534671 – 349Histidinol-phosphate aminotransferaseAdd BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei207N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiP73807
PRIDEiP73807

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi1148.SYNGTS_1285

Structurei

3D structure databases

ProteinModelPortaliP73807
SMRiP73807
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000288510
InParanoidiP73807
KOiK00817
OMAiHGFLVYR
PhylomeDBiP73807

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01023 HisC_aminotrans_2, 1 hit
InterProiView protein in InterPro
IPR001917 Aminotrans_II_pyridoxalP_BS
IPR004839 Aminotransferase_I/II
IPR005861 HisP_aminotrans
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01141 hisC, 1 hit
PROSITEiView protein in PROSITE
PS00599 AA_TRANSFER_CLASS_2, 1 hit

Sequencei

Sequence statusi: Complete.

P73807-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSIRPSVRH TPAYVPGEQP QTNDFIKLNT NENPYDPPAQ VLAAVAAELP
60 70 80 90 100
KVRLYPDPVS TQLRQAAADL YGVDLNQVLA GNGSDDILNI VVRTFVDPGE
110 120 130 140 150
TVAFLDLTYS LYETIASVHG AKVQKIATDA NFDLTGPVIC PEAKLIFLAS
160 170 180 190 200
PNPPKGKHLN REFLWQTCAQ AEGVVVIDEA YGDFSDEDHW DFLQEFDNVI
210 220 230 240 250
ISRTLSKSYS LAGMRVGLAI AAPALIEEMD KVRDSYNLDR LAQVLGTAAL
260 270 280 290 300
RNQAEFVPLW EKVRHTRTRL MEQLAELDFQ VCPSDANFVF AAPRWMAAAD
310 320 330 340
LYQALKEKKI LVRYFNHPRI TDYLRITVGT DGEIDQLLLA IASLKGSLG
Length:349
Mass (Da):38,702
Last modified:April 26, 2004 - v2
Checksum:i239C3F26DCF4F2C6
GO

Sequence cautioni

The sequence BAA17861 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA17861.1 Different initiation.
PIRiS74900

Genome annotation databases

EnsemblBacteriaiBAA17861; BAA17861; BAA17861
KEGGisyn:sll1958

Similar proteinsi

Entry informationi

Entry nameiHIS8_SYNY3
AccessioniPrimary (citable) accession number: P73807
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 26, 2004
Last modified: May 23, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

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