UniProtKB - P73689 (SPPA_SYNY3)
Protein
Protease 4
Gene
sppA
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Functioni
Digests cleaved signal peptides in vitro, its in vivo function is unknown. This activity is necessary to maintain proper secretion of mature proteins across the membrane (By similarity).By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 195 | Proton donor/acceptorBy similarity | 1 | |
Active sitei | 401 | NucleophileBy similarity | 1 |
GO - Molecular functioni
- serine-type peptidase activity Source: UniProtKB-KW
GO - Biological processi
- signal peptide processing Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Names & Taxonomyi
Protein namesi | Recommended name: Protease 4 (EC:3.4.21.-)Alternative name(s): Endopeptidase IV Protease IV homolog Signal peptide peptidase |
Gene namesi | Name:sppA Ordered Locus Names:sll1703 |
Organismi | Synechocystis sp. (strain PCC 6803 / Kazusa) |
Taxonomic identifieri | 1111708 [NCBI] |
Taxonomic lineagei | Bacteria › Cyanobacteria › Synechococcales › Merismopediaceae › Synechocystis › unclassified Synechocystis › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane By similarity; Single-pass membrane protein By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 16 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 17 – 37 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 38 – 610 | PeriplasmicSequence analysisAdd BLAST | 573 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000171440 | 1 – 610 | Protease 4Add BLAST | 610 |
Proteomic databases
PaxDbi | P73689 |
Interactioni
Subunit structurei
Homotetramer.
By similarityProtein-protein interaction databases
IntActi | P73689, 2 interactors |
STRINGi | 1148.1652816 |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 212 – 215 | Poly-Gln | 4 |
Sequence similaritiesi
Belongs to the peptidase S49 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0616, Bacteria |
InParanoidi | P73689 |
OMAi | DPKGQYL |
PhylomeDBi | P73689 |
Family and domain databases
CDDi | cd07023, S49_Sppa_N_C, 1 hit |
InterProi | View protein in InterPro IPR029045, ClpP/crotonase-like_dom_sf IPR004634, Pept_S49_pIV IPR004635, Pept_S49_SppA IPR002142, Peptidase_S49 |
Pfami | View protein in Pfam PF01343, Peptidase_S49, 2 hits |
PIRSFi | PIRSF001217, Protease_4_SppA, 1 hit |
SUPFAMi | SSF52096, SSF52096, 2 hits |
TIGRFAMsi | TIGR00705, SppA_67K, 1 hit TIGR00706, SppA_dom, 1 hit |
i Sequence
Sequence statusi: Complete.
P73689-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKNFFQQMVA SFFGTLAAIV VLLSLGATGL VLLFILVSAE ADPVLEEKTA
60 70 80 90 100
LILDLAIPIQ DTSPTLSLQQ SLLGNQEEIL PLRTVVNAIE KAAEDDRIVA
110 120 130 140 150
LLIDGRRSNQ VDGYANLSEV QQALIKFKQS GKKIVAYGLN YSELGYYLAA
160 170 180 190 200
TADTILINPM GGVEINGLGA QPIFFTGALA KAGIGVQTLR VGSYKGAVEP
210 220 230 240 250
YTRENLSPEN RQQQQLLLNQ IWQIYLTSVA NNRSLTVPQL QAIASDQGLL
260 270 280 290 300
FADIALREKL VDKVTYWDEV LAELKQAGVW INDPEKIEEQ EEDKEFRKIS
310 320 330 340 350
LAEYHRLQNW ETENHDQDPK IAIVYLEGSI VNGRGTWENI GGDRYGELLR
360 370 380 390 400
TIRQDDDIKA VVLRINSPGG SASAADIIWR EVELLQAQKP VIISMGNVAA
410 420 430 440 450
SGGYWIATAG EKIVAQPNTV TGSIGVFSIL FNVENLGDRL GLNWDEVATG
460 470 480 490 500
ELANVGSSIK PKTELELAIF QRSVDQVYEI FLDKVGRARN LSPTALDSVA
510 520 530 540 550
QGRVWTGLAA QKVGLVDQLG GLQTAVNLAA AQAELGEQWQ VKEYPTPRGL
560 570 580 590 600
NSLLWNNLIH GLTETNSVVL PPFLRTNWQQ LEREWAELAQ FNDPQGIYAR
610
LPFSWHFLNP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BA000022 Genomic DNA Translation: BAA17735.1 |
PIRi | S77177 |
Genome annotation databases
EnsemblBacteriai | BAA17735; BAA17735; BAA17735 |
KEGGi | syn:sll1703 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BA000022 Genomic DNA Translation: BAA17735.1 |
PIRi | S77177 |
3D structure databases
SMRi | P73689 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P73689, 2 interactors |
STRINGi | 1148.1652816 |
Proteomic databases
PaxDbi | P73689 |
Genome annotation databases
EnsemblBacteriai | BAA17735; BAA17735; BAA17735 |
KEGGi | syn:sll1703 |
Phylogenomic databases
eggNOGi | COG0616, Bacteria |
InParanoidi | P73689 |
OMAi | DPKGQYL |
PhylomeDBi | P73689 |
Family and domain databases
CDDi | cd07023, S49_Sppa_N_C, 1 hit |
InterProi | View protein in InterPro IPR029045, ClpP/crotonase-like_dom_sf IPR004634, Pept_S49_pIV IPR004635, Pept_S49_SppA IPR002142, Peptidase_S49 |
Pfami | View protein in Pfam PF01343, Peptidase_S49, 2 hits |
PIRSFi | PIRSF001217, Protease_4_SppA, 1 hit |
SUPFAMi | SSF52096, SSF52096, 2 hits |
TIGRFAMsi | TIGR00705, SppA_67K, 1 hit TIGR00706, SppA_dom, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SPPA_SYNY3 | |
Accessioni | P73689Primary (citable) accession number: P73689 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families