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Protein

Probable copper-transporting ATPase PacS

Gene

pacS

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the osmotic adaptation.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.
ATP + H2O + Cu+(Side 1) = ADP + phosphate + Cu+(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi14PROSITE-ProRule annotation1
Metal bindingi17PROSITE-ProRule annotation1
Active sitei4284-aspartylphosphate intermediateCurated1
Metal bindingi633MagnesiumPROSITE-ProRule annotation1
Metal bindingi637MagnesiumPROSITE-ProRule annotation1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • cation-transporting ATPase activity Source: InterPro
  • copper ion binding Source: UniProtKB

GO - Biological processi

  • copper ion import Source: UniProtKB

Keywordsi

Molecular functionHydrolase
Biological processCopper transport, Ion transport, Transport
LigandATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable copper-transporting ATPase PacS (EC:3.6.3.54)
Gene namesi
Name:pacS
Ordered Locus Names:sll1920
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 94CytoplasmicSequence analysisAdd BLAST94
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Topological domaini116 – 125ExtracellularSequence analysis10
Transmembranei126 – 145HelicalSequence analysisAdd BLAST20
Topological domaini146 – 152CytoplasmicSequence analysis7
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Topological domaini174 – 193ExtracellularSequence analysisAdd BLAST20
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Topological domaini215 – 342CytoplasmicSequence analysisAdd BLAST128
Transmembranei343 – 365HelicalSequence analysisAdd BLAST23
Topological domaini366 – 372ExtracellularSequence analysis7
Transmembranei373 – 390HelicalSequence analysisAdd BLAST18
Topological domaini391 – 543CytoplasmicSequence analysisAdd BLAST153
Transmembranei544 – 564HelicalSequence analysisAdd BLAST21
Topological domaini565 – 687ExtracellularSequence analysisAdd BLAST123
Transmembranei688 – 707HelicalSequence analysisAdd BLAST20
Topological domaini708 – 719CytoplasmicSequence analysisAdd BLAST12
Transmembranei720 – 738HelicalSequence analysisAdd BLAST19
Topological domaini739 – 745ExtracellularSequence analysis7

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000461611 – 745Probable copper-transporting ATPase PacSAdd BLAST745

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP73241
PRIDEiP73241

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ssr2857P732133EBI-904982,EBI-904975

Protein-protein interaction databases

DIPiDIP-35107N
IntActiP73241, 11 interactors
STRINGi1148.SYNGTS_0693

Structurei

Secondary structure

1745
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP73241
SMRiP73241
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP73241

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 69HMAPROSITE-ProRule annotationAdd BLAST66

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000250397
InParanoidiP73241
KOiK17686
OMAiHIFGGPL
PhylomeDBiP73241

Family and domain databases

CDDicd00371 HMA, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR017969 Heavy-metal-associated_CS
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
IPR027256 P-typ_ATPase_IB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00403 HMA, 1 hit
SUPFAMiSSF55008 SSF55008, 1 hit
SSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01525 ATPase-IB_hvy, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
PS01047 HMA_1, 1 hit
PS50846 HMA_2, 1 hit

Sequencei

Sequence statusi: Complete.

P73241-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQTINLQLE GMRCAACASS IERAIAKVPG VQSCQVNFAL EQAVVSYHGE
60 70 80 90 100
TTPQILTDAV ERAGYHARVL KQQVLSSQQT EDRKPVFSAK LVTGLVISAV
110 120 130 140 150
LFFGSLPMML GVNIPHFPHI FHDPWLQWLL ATPVQFWSGA EFYRGAWKSV
160 170 180 190 200
RTRSATMDTL VALGTSAAYF YSVAITLFPQ WLTSQGLAAH VYFEAAAVVI
210 220 230 240 250
TLILLGRSLE QRARRETSAA IRKLMGLQPQ TALVKRGEHW ETVAIAELAI
260 270 280 290 300
NDVVRVRPGE KIPVDGVVVA GNSTVDESLV TGESFPVDKT VGTEVIGATL
310 320 330 340 350
NKSGSLDIQV SKLGQDSVLA QIIQLVQQAQ ASKAPIQHFV DRITHWFVPT
360 370 380 390 400
VIVVAIAAFC IWWLTTGNIT LAVLTLVEVL IIACPCALGL ATPTSVMVGT
410 420 430 440 450
GKGAEYGVLI KEASSLEMAE KLTAIVLDKT GTLTQGKPSV TNFFTLSPTS
460 470 480 490 500
TEESLQLIQW AASVEQYSEH PLAEAVVNYG QSQQVSLLEI DNFQAIAGCG
510 520 530 540 550
VAGQWQGQWI RLGTSNWLTD LGVTGTEHQP WQSQAQQWEK EQKTVIWLAV
560 570 580 590 600
DTEVKALLAI ADAIKPSSPQ VVQALKKLGL SVYMLTGDNQ ATAQAIADTV
610 620 630 640 650
GIRHVLAQVR PGDKAQQVEQ LQQKGNIVAM VGDGINDAPA LAQADVGIAI
660 670 680 690 700
GTGTDVAIAA SDITLIAGDL QGILTAIKLS RATMGNIRQN LFFAFIYNVI
710 720 730 740
GIPVAAGLFY PLFGLLLNPI LAGAAMAFSS VSVVTNALRL KKFCP
Length:745
Mass (Da):79,950
Last modified:February 1, 1997 - v1
Checksum:i40831F66621735FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA17268.1
PIRiS75354

Genome annotation databases

EnsemblBacteriaiBAA17268; BAA17268; BAA17268
KEGGisyn:sll1920

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA17268.1
PIRiS75354

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GCFNMR-A1-73[»]
2XMWX-ray1.80A1-71[»]
4A48X-ray1.40A/B2-70[»]
4A4JX-ray1.25A2-70[»]
ProteinModelPortaliP73241
SMRiP73241
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-35107N
IntActiP73241, 11 interactors
STRINGi1148.SYNGTS_0693

Proteomic databases

PaxDbiP73241
PRIDEiP73241

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA17268; BAA17268; BAA17268
KEGGisyn:sll1920

Phylogenomic databases

HOGENOMiHOG000250397
InParanoidiP73241
KOiK17686
OMAiHIFGGPL
PhylomeDBiP73241

Miscellaneous databases

EvolutionaryTraceiP73241

Family and domain databases

CDDicd00371 HMA, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR017969 Heavy-metal-associated_CS
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
IPR027256 P-typ_ATPase_IB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00403 HMA, 1 hit
SUPFAMiSSF55008 SSF55008, 1 hit
SSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01525 ATPase-IB_hvy, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
PS01047 HMA_1, 1 hit
PS50846 HMA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiATCS_SYNY3
AccessioniPrimary (citable) accession number: P73241
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: February 28, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names
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Main funding by: National Institutes of Health

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