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Protein

NAD(P)H-quinone oxidoreductase chain 4-2

Gene

ndhD2

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

Catalytic activityi

NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP, Plastoquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NAD(P)H-quinone oxidoreductase chain 4-2 (EC:1.6.5.-)
Alternative name(s):
NAD(P)H dehydrogenase I, subunit D-2
NDH-1, chain 4-2
Gene namesi
Name:ndhD2
Ordered Locus Names:slr1291
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Transmembranei207 – 227HelicalSequence analysisAdd BLAST21
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Transmembranei331 – 351HelicalSequence analysisAdd BLAST21
Transmembranei374 – 394HelicalSequence analysisAdd BLAST21
Transmembranei417 – 437HelicalSequence analysisAdd BLAST21
Transmembranei488 – 508HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Thylakoid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001180361 – 559NAD(P)H-quinone oxidoreductase chain 4-2Add BLAST559

Keywords - PTMi

Quinone

Proteomic databases

PaxDbiP72823

Interactioni

Protein-protein interaction databases

IntActiP72823, 2 interactors
STRINGi1148.SYNGTS_0262

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000100683
InParanoidiP72823
KOiK05575
OMAiVSIWGGQ
PhylomeDBiP72823

Family and domain databases

HAMAPiMF_00491 NDH1_NuoM, 1 hit
InterProiView protein in InterPro
IPR022997 NADH_Q_OxRdtase_chain4
IPR010227 NADH_Q_OxRdtase_chainM/4
IPR003918 NADH_UbQ_OxRdtase
IPR001750 ND/Mrp_mem
PANTHERiPTHR43507 PTHR43507, 1 hit
PTHR43507:SF3 PTHR43507:SF3, 1 hit
PfamiView protein in Pfam
PF00361 Proton_antipo_M, 1 hit
PRINTSiPR01437 NUOXDRDTASE4
TIGRFAMsiTIGR01972 NDH_I_M, 1 hit

Sequencei

Sequence statusi: Complete.

P72823-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEHFPWLTT MIALPLVAAL FIPLIPDKDG KQVRWYALGV GLADFVLMSY
60 70 80 90 100
VFWTNYDISS TGFQLQEKFS WIPQFGLSWS VSVDGISMPL VLLAGLVTTL
110 120 130 140 150
SIFAAWQVDH KPRLFYFLML VLYAAQIGVF VAQDMLLLFI MWELELVPVY
160 170 180 190 200
LLVCIWGGQK RQYAAMKFLL YTAAASVFIL VAALGLAFYG DVTTFDIAEL
210 220 230 240 250
GLKDYPIALE LFLYAGLLIA FGVKLAIFPF HTWLPDAHGE ASAPVSMILA
260 270 280 290 300
GVLLKMGGYG LIRLNLGLLE DAHVYFAPIL VILGVVNIIY GGFSSFAQDN
310 320 330 340 350
MKRRLAYSSV SHMGFVLLGI ASFTDLGISG AMLQMLSHGL IAAVLFFLAG
360 370 380 390 400
VTYDRTHTLS LAQMGNIGKV MPTVFALFTM GAMASLALPG MSGFVSELAV
410 420 430 440 450
FVGVSSSDIY STPFKTVTVF LAAVGLVLTP IYLLSMLRQL FYGNNIPPSC
460 470 480 490 500
NLEQDNLSAN SDQEAVCFGT SCVLPGNAIY DDARPREVFI AACFLLPIIA
510 520 530 540 550
VGLYPKLATQ TYDATTVAVN SQVRQSYVQI AETNPRVYAE ALTAPHIPTT

DFATVKVQP
Length:559
Mass (Da):61,007
Last modified:February 1, 1997 - v1
Checksum:i168DD5302A8810A3
GO

Sequence cautioni

The sequence AAA85105 differs from that shown. Reason: Frameshift at positions 494 and 515.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64Q → I in AAA85105 (PubMed:7846157).Curated1
Sequence conflicti109 – 110DH → TS in AAA85105 (PubMed:7846157).Curated2
Sequence conflicti120 – 121LV → VL in AAA85105 (PubMed:7846157).Curated2
Sequence conflicti124A → S in AAA85105 (PubMed:7846157).Curated1
Sequence conflicti128 – 130GVF → VLI in AAA85105 (PubMed:7846157).Curated3
Sequence conflicti135M → R (PubMed:7846157).Curated1
Sequence conflicti139F → LS (PubMed:7846157).Curated1
Sequence conflicti154 – 155CI → VS in AAA85105 (PubMed:7846157).Curated2
Sequence conflicti183 – 184AL → P in AAA85105 (PubMed:7846157).Curated2
Sequence conflicti187A → S in AAA85105 (PubMed:7846157).Curated1
Sequence conflicti215 – 227AGLLI…VKLAI → TGLALVAFAVKISH (PubMed:7846157).CuratedAdd BLAST13
Sequence conflicti299 – 301DNM → AH in AAA85105 (PubMed:7846157).Curated3
Sequence conflicti319 – 332GIASF…ISGAM → LFSITIGIMDH (PubMed:7846157).CuratedAdd BLAST14
Sequence conflicti343A → R in AAA85105 (PubMed:7846157).Curated1
Sequence conflicti348 – 349LA → PWT in AAA85105 (PubMed:7846157).Curated2
Sequence conflicti357H → N in AAA85105 (PubMed:7846157).Curated1
Sequence conflicti379T → P in AAA85105 (PubMed:7846157).Curated1
Sequence conflicti522Q → QE (PubMed:7846157).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14130 Genomic DNA Translation: AAA85105.1 Frameshift.
BA000022 Genomic DNA Translation: BAA16838.1
PIRiS74687
T14239

Genome annotation databases

EnsemblBacteriaiBAA16838; BAA16838; BAA16838
KEGGisyn:slr1291

Similar proteinsi

Entry informationi

Entry nameiNU4C2_SYNY3
AccessioniPrimary (citable) accession number: P72823
Secondary accession number(s): Q55021
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: February 1, 1997
Last modified: July 18, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

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