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Protein

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

Gene

folK

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 6-hydroxymethyl-7,8-dihydropterin = AMP + 6-hydroxymethyl-7,8-dihydropterin diphosphate.

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Probable dihydroneopterin aldolase (folB)
  4. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (folK)
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processFolate biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00077; UER00155.

Names & Taxonomyi

Protein namesi
Recommended name:
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC:2.7.6.3)
Alternative name(s):
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Short name:
PPPK
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Short name:
HPPK
Gene namesi
Name:folK
Ordered Locus Names:slr1093
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001682641 – 1952-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinaseAdd BLAST195

Proteomic databases

PaxDbiP72736.

Interactioni

Protein-protein interaction databases

STRINGi1148.SYNGTS_0175.

Structurei

3D structure databases

ProteinModelPortaliP72736.
SMRiP72736.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HPPK family.Curated

Phylogenomic databases

HOGENOMiHOG000217741.
InParanoidiP72736.
KOiK00950.
OMAiKDERWGP.
PhylomeDBiP72736.

Family and domain databases

CDDicd00483. HPPK. 1 hit.
Gene3Di3.30.70.560. 1 hit.
InterProiView protein in InterPro
IPR000550. Hppk.
IPR035907. Hppk_sf.
PfamiView protein in Pfam
PF01288. HPPK. 1 hit.
SUPFAMiSSF55083. SSF55083. 1 hit.
TIGRFAMsiTIGR01498. folK. 1 hit.
PROSITEiView protein in PROSITE
PS00794. HPPK. 1 hit.

Sequencei

Sequence statusi: Complete.

P72736-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPVSPTDFP QQCHGAVVGL GGNIGPVLDN LQGAIAELAL VAGIEVERCS
60 70 80 90 100
SWYRSRAFGP PQPDYINGCV TLRVSLSPPE LLQTLLAIEQ KFGRIRLEKW
110 120 130 140 150
GPRTLDLDLI FYGDRQLEQA RLTIPHPQMQ YRPFVLVPLA EIAPDWVDPR
160 170 180 190
SGKTIIQLIE QVDCTAVWPV APGLELGGSL EPEQVFAPGA VAVHG
Length:195
Mass (Da):21,237
Last modified:February 1, 1997 - v1
Checksum:iD242AD9F221D7C88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA16751.1.
PIRiS74599.

Genome annotation databases

EnsemblBacteriaiBAA16751; BAA16751; BAA16751.
KEGGisyn:slr1093.

Similar proteinsi

Entry informationi

Entry nameiHPPK_SYNY3
AccessioniPrimary (citable) accession number: P72736
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 1, 1997
Last modified: January 31, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome