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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi502 – 509GTPBy similarity8
Nucleotide bindingi552 – 556GTPBy similarity5
Nucleotide bindingi606 – 609GTPBy similarity4

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2
Gene namesi
Name:infB
Ordered Locus Names:slr0744
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001372691 – 1001Translation initiation factor IF-2Add BLAST1001

Proteomic databases

PaxDbiP72689
PRIDEiP72689

Interactioni

Protein-protein interaction databases

IntActiP72689, 4 interactors
STRINGi1148.SYNGTS_0120

Structurei

3D structure databases

ProteinModelPortaliP72689
SMRiP72689
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini493 – 666tr-type GAdd BLAST174

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni502 – 509G1By similarity8
Regioni527 – 531G2By similarity5
Regioni552 – 555G3By similarity4
Regioni606 – 609G4By similarity4
Regioni642 – 644G5By similarity3

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000076906
InParanoidiP72689
KOiK02519
OMAiNIAVKSH
PhylomeDBiP72689

Family and domain databases

Gene3Di3.40.50.10050, 1 hit
HAMAPiMF_00100_B IF_2_B, 1 hit
InterProiView protein in InterPro
IPR006847 IF2_N
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR000178 TF_IF2_bacterial-like
IPR015760 TIF_IF2
IPR023115 TIF_IF2_dom3
IPR036925 TIF_IF2_dom3_sf
IPR009000 Transl_B-barrel_sf
PANTHERiPTHR43381 PTHR43381, 1 hit
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PF11987 IF-2, 1 hit
PF04760 IF2_N, 2 hits
PRINTSiPR00315 ELONGATNFCT
SUPFAMiSSF50447 SSF50447, 2 hits
SSF52156 SSF52156, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00487 IF-2, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51722 G_TR_2, 1 hit
PS01176 IF2, 1 hit

Sequencei

Sequence statusi: Complete.

P72689-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNAKVRIYD LSKELNLENR DILDICERLN VAAKSHSSTI SESDAERIKA
60 70 80 90 100
AAEKFTPQQP KKPRVASRPE SKEDKSDPKQ QKILAIHHKQ EKSGGPSPAR
110 120 130 140 150
PTPPPRPKLQ APKAPTPPQP PVAKASAPKI QKQEEPAQEA PKSVAPPTQP
160 170 180 190 200
LAPPPVPSLQ SPPSKPAPPT PPAKKAAPAP RLAGPPGRTA SPNKTAVPAP
210 220 230 240 250
AKPKVNRPEI VSLKDNRGQA RSPGDREEKV AIAAPEPPKP KVELRRPKPP
260 270 280 290 300
RPEEDENLPE LLEFPPLSRG KGVDGDNDAD DGDLLSTEKP KPKLKRPTPP
310 320 330 340 350
RLGKPDQWED DEDEKANKAK AANKGKRRPK MDDDDDDLDI DGDNGPKPTL
360 370 380 390 400
VSLSIARPPK PKSLAAKPST PTVAKVKKPT LKSEAGSSAG GSSRSRGDRR
410 420 430 440 450
DRKEVVQKPE VIMLDRSLTV RDLADLLKIS ETDIIKRLFL KGVAVQITQT
460 470 480 490 500
LDEETARMVA ESFEVAVETP ERVAAAAKTT EMLDEADLDN LVRRPPVVTI
510 520 530 540 550
MGHVDHGKTT LLDSIRKTKV AQGEAGGITQ HIGAYHVEVE HNDKTEQIVF
560 570 580 590 600
LDTPGHEAFT AMRARGAKVT DIAILVVAAD DGVQPQTKEA ISHAKAAGVP
610 620 630 640 650
LIVAINKVDK PEANPDRIKQ ELSELGLLAE EWGGDTIMVP VSALNGDNLD
660 670 680 690 700
GLLEMILLVS EVEELVANPN RQAKGTVIEA NLDRTRGPVA TLLIQNGTLR
710 720 730 740 750
VGDAIVVGAV YGKIRAMIDD RGDKVEEASP SFAVEILGLG DVPAAGDEFE
760 770 780 790 800
VFTNEKDARL QAEARAMEDR QTRLQQAMSS RKVTLSSISA QAQEGELKEL
810 820 830 840 850
NIILKADVQG SLGAILGSLE QLPQGEVQIR VLLASPGEVT ETDVDLAAAS
860 870 880 890 900
GAIIIGFNTT LASGARQAAD QEGVDIREYD IIYKLLDDIQ GAMEGLLDPE
910 920 930 940 950
EIESSLGTAE VRAVFPVGRG NIAGCYVQSG KIIRNRNLRV RRGDQVLFEG
960 970 980 990 1000
NIDSLKRIKE DVREVNAGYE CGIGCSKFND WKEGDIIEAY EMTMKRRTLA

T
Length:1,001
Mass (Da):108,119
Last modified:February 1, 1997 - v1
Checksum:i4C7F00DEE56CE31C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA16696.1
PIRiS74544

Genome annotation databases

EnsemblBacteriaiBAA16696; BAA16696; BAA16696
KEGGisyn:slr0744

Similar proteinsi

Entry informationi

Entry nameiIF2_SYNY3
AccessioniPrimary (citable) accession number: P72689
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: January 31, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

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