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Protein

Alcohol dehydrogenase class-3

Gene

adhI

Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Oxidizes long-chain aliphatic alcohols, long-chain hydroxylated fatty acids and S-hydroxymethylglutathione (hmGSH) in increasing order of preference. Shows little or no activity with short-chain aliphatic alcohols.

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.
S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi40Zinc 1; catalyticBy similarity1
Metal bindingi62Zinc 1; catalyticBy similarity1
Metal bindingi92Zinc 2By similarity1
Metal bindingi95Zinc 2By similarity1
Metal bindingi98Zinc 2By similarity1
Metal bindingi106Zinc 2By similarity1
Metal bindingi170Zinc 1; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

  • ethanol oxidation Source: InterPro
  • methanol metabolic process Source: CACAO

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase class-3 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase class-III
Glutathione-dependent formaldehyde dehydrogenase (EC:1.1.1.-)
Short name:
FALDH
Short name:
FDH
Short name:
GSH-FDH
S-(hydroxymethyl)glutathione dehydrogenase (EC:1.1.1.284)
Gene namesi
Name:adhI
Ordered Locus Names:RHOS4_11650
ORF Names:RSP_2576
OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Taxonomic identifieri272943 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
Proteomesi
  • UP000002703 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607801 – 376Alcohol dehydrogenase class-3Add BLAST376

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi272943.RSP_2576

Structurei

3D structure databases

ProteinModelPortaliP72324
SMRiP72324
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107QPD Bacteria
COG1062 LUCA
HOGENOMiHOG000294674
KOiK00121
OMAiATHKGWG
OrthoDBiPOG091H04U5
PhylomeDBiP72324

Family and domain databases

CDDicd08300 alcohol_DH_class_III, 1 hit
InterProiView protein in InterPro
IPR014183 ADH_3
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR02818 adh_III_F_hyde, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P72324-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTRAAVAVE AGKPLEIMEV NLEGPKAGEV MVEIKATGIC HTDEFTLSGA
60 70 80 90 100
DPEGMFPAIL GHEGAGVVVE VGPGVTSVKP GDHVIPLYTP ECRQCPSCLS
110 120 130 140 150
QKTNLCTAIR GTQGQGLMPD GTSRFSMLDG TPILHYMGCS TFSNYTVLPE
160 170 180 190 200
IAVAKVRPDA PFDKICYIGC GVTTGIGAVI NTAKVEIGAK AVVFGLGGIG
210 220 230 240 250
LNVIQGLKLA GADMIIGVDL NNAKKEWGER FGMTHFVNPS EIDGDVVAHL
260 270 280 290 300
VNMTKTPFDQ IGGADYTFDC TGNVKVMRQA LEACHRGWGQ SIVIGVAPAG
310 320 330 340 350
AEIQTRPFQL VTGRVWKGSA FGGARGRTDV PKIVDWYMEG KIQIDPMITH
360 370
ILSLEEINKG FDLMHAGESI RSVVVF
Length:376
Mass (Da):39,974
Last modified:February 1, 1997 - v1
Checksum:i9144690996B32BB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47326 Genomic DNA Translation: AAB09774.1
CP000143 Genomic DNA Translation: ABA78733.1
RefSeqiWP_009564386.1, NZ_CP030271.1
YP_352634.1, NC_007493.2

Genome annotation databases

EnsemblBacteriaiABA78733; ABA78733; RSP_2576
GeneIDi3720209
KEGGirsp:RSP_2576
PATRICifig|272943.9.peg.1494

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47326 Genomic DNA Translation: AAB09774.1
CP000143 Genomic DNA Translation: ABA78733.1
RefSeqiWP_009564386.1, NZ_CP030271.1
YP_352634.1, NC_007493.2

3D structure databases

ProteinModelPortaliP72324
SMRiP72324
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272943.RSP_2576

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA78733; ABA78733; RSP_2576
GeneIDi3720209
KEGGirsp:RSP_2576
PATRICifig|272943.9.peg.1494

Phylogenomic databases

eggNOGiENOG4107QPD Bacteria
COG1062 LUCA
HOGENOMiHOG000294674
KOiK00121
OMAiATHKGWG
OrthoDBiPOG091H04U5
PhylomeDBiP72324

Family and domain databases

CDDicd08300 alcohol_DH_class_III, 1 hit
InterProiView protein in InterPro
IPR014183 ADH_3
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR02818 adh_III_F_hyde, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADHI_RHOS4
AccessioniPrimary (citable) accession number: P72324
Secondary accession number(s): Q3J3A1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 7, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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