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Entry version 123 (07 Oct 2020)
Sequence version 2 (03 Apr 2002)
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Protein

Pyrolysin

Gene

pls

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has endopeptidase activity toward caseins, casein fragments including alpha-S1-casein and synthetic peptides.

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Temperature dependencei

Thermostable. Highly active at 95 degrees Celsius.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei179Charge relay systemPROSITE-ProRule annotation1
Active sitei365Charge relay systemPROSITE-ProRule annotation1
Active sitei590Charge relay systemPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
PFUR186497:G1FZR-296-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.21.B55, 5243

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S08.100

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pyrolysin (EC:3.4.21.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pls
Ordered Locus Names:PF0287
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri186497 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001013 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002712827 – 1491 PublicationAdd BLAST123
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000027129150 – 1398PyrolysinAdd BLAST1249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi152N-linked (GlcNAc...) asparagine1
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi228N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi240N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi257N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi262N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi298N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi327N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi406N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi651N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi663N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi739N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi792N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi893N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi908N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi917N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi929N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1048N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1056N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1084N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1117N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1133N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1140N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1148N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1208N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1233N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1237N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1332N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

LWM pyrolysin seems to be produced by autoproteolytic activation of HMW pyrolysin.
Glycosylated.

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P72186

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
186497.PF0287

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini154 – 656Peptidase S8PROSITE-ProRule annotationAdd BLAST503

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S8 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
arCOG00704, Archaea
arCOG03610, Archaea

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_264582_0_0_2

Identification of Orthologs from Complete Genome Data

More...
OMAi
KIVDWVT

Database of Orthologous Groups

More...
OrthoDBi
53822at2157

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.200, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007280, Peptidase_C_arc/bac
IPR000209, Peptidase_S8/S53_dom
IPR036852, Peptidase_S8/S53_dom_sf
IPR023827, Peptidase_S8_Asp-AS
IPR022398, Peptidase_S8_His-AS
IPR023828, Peptidase_S8_Ser-AS
IPR015500, Peptidase_S8_subtilisin-rel

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00082, Peptidase_S8, 1 hit
PF04151, PPC, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00723, SUBTILISIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52743, SSF52743, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51892, SUBTILASE, 1 hit
PS00136, SUBTILASE_ASP, 1 hit
PS00137, SUBTILASE_HIS, 1 hit
PS00138, SUBTILASE_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P72186-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKKGLTVLF IAIMLLSVVP VHFVSAGTPP VSSENSTTSI LPNQQVVTKE
60 70 80 90 100
VSQAALNAIM KGQPNMVLII KTKEGKLEEA KTELEKLGAE ILDENRVLNM
110 120 130 140 150
LLVKIKPEKV KELNYISSLE KAWLNREVKL SPPIVEKDVK TKEPSLEPKM
160 170 180 190 200
YNSTWVINAL QFIQEFGYDG SGVVVAVLDT GVDPNHPFLS ITPDGRRKII
210 220 230 240 250
EWKDFTDEGF VDTSFSFSKV VNGTLIINTT FQVASGLTLN ESTGLMEYVV
260 270 280 290 300
KTVYVSNVTI GNITSANGIY HFGLLPERYF DLNFDGDQED FYPVLLVNST
310 320 330 340 350
GNGYDIAYVD TDLDYDFTDE VPLGQYNVTY DVAVFSYYYG PLNYVLAEID
360 370 380 390 400
PNGEYAVFGW DGHGHGTHVA GTVAGYDSNN DAWDWLSMYS GEWEVFSRLY
410 420 430 440 450
GWDYTNVTTD TVQGVAPGAQ IMAIRVLRSD GRGSMWDIIE GMTYAATHGA
460 470 480 490 500
DVISMSLGGN APYLDGTDPE SVAVDELTEK YGVVFVIAAG NEGPGINIVG
510 520 530 540 550
SPGVATKAIT VGAAAVPINV GVYVSQALGY PDYYGFYYFP AYTNVRIAFF
560 570 580 590 600
SSRGPRIDGE IKPNVVAPGY GIYSSLPMWI GGADFMSGTS MATPHVSGVV
610 620 630 640 650
ALLISGAKAE GIYYNPDIIK KVLESGATWL EGDPYTGQKY TELDQGHGLV
660 670 680 690 700
NVTKSWEILK AINGTTLPIV DHWADKSYSD FAEYLGVDVI RGLYARNSIP
710 720 730 740 750
DIVEWHIKYV GDTEYRTFEI YATEPWIKPF VSGSVILENN TEFVLRVKYD
760 770 780 790 800
VEGLEPGLYV GRIIIDDPTT PVIEDEILNT IVIPEKFTPE NNYTLTWYDI
810 820 830 840 850
NGPEMVTHHF FTVPEGVDVL YAMTTYWDYG LYRPDGMFVF PYQLDYLPAA
860 870 880 890 900
VSNPMPGNWE LVWTGFNFAP LYESGFLVRI YGVEITPSVW YINRTYLDTN
910 920 930 940 950
TEFSIEFNIT NIYAPINATL IPIGLGTYNA SVESVGDGEF FIKGIEVPEG
960 970 980 990 1000
TAELKIRIGN PSVPNSDLDL YLYDSKGNLV ALDGNPTAEE EVVVEYPKPG
1010 1020 1030 1040 1050
VYSIVVHGYS VRDENGNPTT TTFDLVVQMT LDNGNIKLDK DSIILGSNES
1060 1070 1080 1090 1100
VVVTANITID RDHPTGVYSG IIEIRDNEVY QDTNTSIAKI PITLVIDKAD
1110 1120 1130 1140 1150
FAVGLTPAEG VLGEARNYTL IVKHALTLEP VPNATVIIGN YTYLTDENGT
1160 1170 1180 1190 1200
VTFTYAPTKL GSDEITVIVK KENFNTLEKT FQITVSEPEI TEEDINEPKL
1210 1220 1230 1240 1250
AMSSPEANAT IVSVEMESEG GVKKTVTVEI TINGTANETA TIVVPVPKKA
1260 1270 1280 1290 1300
ENIEVSGDHV ISYSIEEGEY AKYVIITVKF ASPVTVTVTY TIYAGPRVSI
1310 1320 1330 1340 1350
LTLNFLGYSW YRLYSQKFDE LYQKALELGV DNETLALALS YHEKAKEYYE
1360 1370 1380 1390
KALELSEGNI IQYLGDIRLL PPLRQAYINE MKAVKILEKA IEELEGEE
Length:1,398
Mass (Da):154,475
Last modified:April 3, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i355D873A27D56552
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti607 – 609AKA → PKP in AAB09761 (PubMed:8702780).Curated3
Sequence conflicti881Y → H in AAB09761 (PubMed:8702780).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U55835 Genomic DNA Translation: AAB09761.1
AE009950 Genomic DNA Translation: AAL80411.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T28159

NCBI Reference Sequences

More...
RefSeqi
WP_011011401.1, NZ_CP023154.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAL80411; AAL80411; PF0287

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
41712077

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfu:PF0287

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|186497.12.peg.299

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55835 Genomic DNA Translation: AAB09761.1
AE009950 Genomic DNA Translation: AAL80411.1
PIRiT28159
RefSeqiWP_011011401.1, NZ_CP023154.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi186497.PF0287

Protein family/group databases

MEROPSiS08.100

Proteomic databases

PRIDEiP72186

Genome annotation databases

EnsemblBacteriaiAAL80411; AAL80411; PF0287
GeneIDi41712077
KEGGipfu:PF0287
PATRICifig|186497.12.peg.299

Phylogenomic databases

eggNOGiarCOG00704, Archaea
arCOG03610, Archaea
HOGENOMiCLU_264582_0_0_2
OMAiKIVDWVT
OrthoDBi53822at2157

Enzyme and pathway databases

BioCyciPFUR186497:G1FZR-296-MONOMER
BRENDAi3.4.21.B55, 5243

Family and domain databases

Gene3Di3.40.50.200, 1 hit
InterProiView protein in InterPro
IPR007280, Peptidase_C_arc/bac
IPR000209, Peptidase_S8/S53_dom
IPR036852, Peptidase_S8/S53_dom_sf
IPR023827, Peptidase_S8_Asp-AS
IPR022398, Peptidase_S8_His-AS
IPR023828, Peptidase_S8_Ser-AS
IPR015500, Peptidase_S8_subtilisin-rel
PfamiView protein in Pfam
PF00082, Peptidase_S8, 1 hit
PF04151, PPC, 1 hit
PRINTSiPR00723, SUBTILISIN
SUPFAMiSSF52743, SSF52743, 1 hit
PROSITEiView protein in PROSITE
PS51892, SUBTILASE, 1 hit
PS00136, SUBTILASE_ASP, 1 hit
PS00137, SUBTILASE_HIS, 1 hit
PS00138, SUBTILASE_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLS_PYRFU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P72186
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: April 3, 2002
Last modified: October 7, 2020
This is version 123 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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