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UniProtKB - P72181 (NIRS_PARPN)
Protein
Nitrite reductase
Gene
nirS
Organism
Paracoccus pantotrophus (Thiosphaera pantotropha)
Status
Functioni
Catalytic activityi
Cofactori
hemeNote: Binds 2 heme groups per subunit.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 46 | Iron (heme axial ligand) | 1 | |
Binding sitei | 94 | Heme; covalent | 1 | |
Binding sitei | 97 | Heme; covalent | 1 | |
Metal bindingi | 98 | Iron (heme axial ligand) | 1 | |
Metal bindingi | 229 | Iron (heme D1 proximal ligand) | 1 |
GO - Molecular functioni
- electron transfer activity Source: InterPro
- heme binding Source: InterPro
- hydroxylamine reductase activity Source: UniProtKB-EC
- metal ion binding Source: UniProtKB-KW
- nitrite reductase (NO-forming) activity Source: UniProtKB-EC
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Electron transport, Transport |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
BRENDAi | 1.7.2.1, 4531 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:nirS |
Organismi | Paracoccus pantotrophus (Thiosphaera pantotropha) |
Taxonomic identifieri | 82367 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Paracoccus |
Subcellular locationi
Other locations
Other locations
- periplasmic space Source: UniProtKB-SubCell
Keywords - Cellular componenti
PeriplasmPathology & Biotechi
Chemistry databases
DrugBanki | DB03317, Ferroheme C DB03469, Heme D DB03309, N-cyclohexyltaurine |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | Add BLAST | 29 | |
ChainiPRO_0000006575 | 30 – 596 | Nitrite reductaseAdd BLAST | 567 |
Interactioni
Subunit structurei
Homodimer.
Protein-protein interaction databases
STRINGi | 935565.JAEM01000004_gene3094 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P72181 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P72181 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 77 – 162 | Cytochrome cPROSITE-ProRule annotationAdd BLAST | 86 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 30 – 76 | N-terminal tailAdd BLAST | 47 | |
Regioni | 163 – 596 | D1-heme domainAdd BLAST | 434 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | COG2010, Bacteria |
Family and domain databases
Gene3Di | 1.10.760.10, 1 hit 2.140.10.20, 1 hit |
InterProi | View protein in InterPro IPR009056, Cyt_c-like_dom IPR036909, Cyt_c-like_dom_sf IPR003143, Cyt_cd1_C_sf IPR011048, Haem_d1_sf |
Pfami | View protein in Pfam PF13442, Cytochrome_CBB3, 1 hit |
SUPFAMi | SSF46626, SSF46626, 1 hit SSF51004, SSF51004, 1 hit |
PROSITEi | View protein in PROSITE PS51007, CYTC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P72181-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRQRTPFARP GLLASAALAL VLGPLAASAQ EQVAPPKDPA AALEDHKTRT
60 70 80 90 100
DNRYEPSLDN LAQQDVAAPG APEGVSALSD AQYNEANKIY FERCAGCHGV
110 120 130 140 150
LRKGATGKAL TPDLTRDLGF DYLQSFITYG SPAGMPNWGT SGELSAEQVD
160 170 180 190 200
LMANYLLLDP AAPPEFGMKE MRESWKVHVA PEDRPTQQEN DWDLENLFSV
210 220 230 240 250
TLRDAGQIAL IDGATYEIKS VLDTGYAVHI SRLSASGRYL FVIGRDGKVN
260 270 280 290 300
MIDLWMKEPT TVAEIKIGSE ARSIETSKME GWEDKYAIAG AYWPPQYVIM
310 320 330 340 350
DGETLEPKKI QSTRGMTYDE QEYHPEPRVA AILASHYRPE FIVNVKETGK
360 370 380 390 400
ILLVDYTDLD NLKTTEISAE RFLHDGGLDG SHRYFITAAN ARNKLVVIDT
410 420 430 440 450
KEGKLVAIED TGGQTPHPGR GANFVHPTFG PVWATSHMGD DSVALIGTDP
460 470 480 490 500
EGHPDNAWKI LDSFPALGGG SLFIKTHPNS QYLYVDATLN PEAEISGSVA
510 520 530 540 550
VFDIKAMTGD GSDPEFKTLP IAEWAGITEG QPRVVQGEFN KDGTEVWFSV
560 570 580 590
WNGKDQESAL VVVDDKTLEL KHVIKDERLV TPTGKFNVYN TMTDTY
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 28 | S → A in AAB17878 (PubMed:10708389).Curated | 1 | |
Sequence conflicti | 76 | S → T in AAB17878 (PubMed:10708389).Curated | 1 | |
Sequence conflicti | 130 | G → A in AAB17878 (PubMed:10708389).Curated | 1 | |
Sequence conflicti | 214 | A → T in AAB17878 (PubMed:10708389).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U75413 Genomic DNA Translation: AAB17878.1 AJ401462 Genomic DNA Translation: CAC03621.1 |
RefSeqi | WP_024843009.1, NZ_RIAQ01000012.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U75413 Genomic DNA Translation: AAB17878.1 AJ401462 Genomic DNA Translation: CAC03621.1 |
RefSeqi | WP_024843009.1, NZ_RIAQ01000012.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AOF | X-ray | 2.00 | A/B | 30-596 | [»] | |
1AOM | X-ray | 1.80 | A/B | 30-596 | [»] | |
1AOQ | X-ray | 1.80 | A/B | 30-596 | [»] | |
1DY7 | X-ray | 1.60 | A/B | 30-596 | [»] | |
1E2R | X-ray | 1.59 | A/B | 30-596 | [»] | |
1GQ1 | X-ray | 1.40 | A/B | 30-596 | [»] | |
1H9X | X-ray | 2.10 | A/B | 30-596 | [»] | |
1H9Y | X-ray | 2.40 | A/B | 30-596 | [»] | |
1HCM | X-ray | 2.50 | A/B | 30-596 | [»] | |
1HJ3 | X-ray | 1.60 | A/B | 30-596 | [»] | |
1HJ4 | X-ray | 1.60 | A/B | 30-596 | [»] | |
1HJ5 | X-ray | 1.46 | A/B | 30-596 | [»] | |
1QKS | X-ray | 1.28 | A/B | 30-596 | [»] | |
SMRi | P72181 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 935565.JAEM01000004_gene3094 |
Chemistry databases
DrugBanki | DB03317, Ferroheme C DB03469, Heme D DB03309, N-cyclohexyltaurine |
Phylogenomic databases
eggNOGi | COG2010, Bacteria |
Enzyme and pathway databases
BRENDAi | 1.7.2.1, 4531 |
Miscellaneous databases
EvolutionaryTracei | P72181 |
Family and domain databases
Gene3Di | 1.10.760.10, 1 hit 2.140.10.20, 1 hit |
InterProi | View protein in InterPro IPR009056, Cyt_c-like_dom IPR036909, Cyt_c-like_dom_sf IPR003143, Cyt_cd1_C_sf IPR011048, Haem_d1_sf |
Pfami | View protein in Pfam PF13442, Cytochrome_CBB3, 1 hit |
SUPFAMi | SSF46626, SSF46626, 1 hit SSF51004, SSF51004, 1 hit |
PROSITEi | View protein in PROSITE PS51007, CYTC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NIRS_PARPN | |
Accessioni | P72181Primary (citable) accession number: P72181 Secondary accession number(s): Q9FCQ0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 8, 2002 | |
Last modified: | February 23, 2022 | |
This is version 124 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references