UniProtKB - P72157 (PURE_PSEAE)
Protein
N5-carboxyaminoimidazole ribonucleotide mutase
Gene
purE
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Functioni
Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).UniRule annotation
Catalytic activityi
- 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H+ = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylateUniRule annotationEC:5.4.99.18UniRule annotation
: IMP biosynthesis via de novo pathway Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route).UniRule annotationProteins known to be involved in the 2 steps of the subpathway in this organism are:
- N5-carboxyaminoimidazole ribonucleotide synthase (purK)
- N5-carboxyaminoimidazole ribonucleotide mutase (purE)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 11 | SubstrateUniRule annotation | 1 | |
Binding sitei | 14 | SubstrateUniRule annotation | 1 | |
Binding sitei | 41 | SubstrateUniRule annotation | 1 |
GO - Molecular functioni
- 5-(carboxyamino)imidazole ribonucleotide mutase activity Source: UniProtKB-UniRule
GO - Biological processi
- 'de novo' IMP biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Isomerase |
Biological process | Purine biosynthesis |
Enzyme and pathway databases
BioCyci | PAER208964:G1FZ6-5553-MONOMER |
UniPathwayi | UPA00074;UER00943 |
Names & Taxonomyi
Protein namesi | Recommended name: N5-carboxyaminoimidazole ribonucleotide mutaseUniRule annotation (EC:5.4.99.18UniRule annotation)Short name: N5-CAIR mutaseUniRule annotation Alternative name(s): 5-(carboxyamino)imidazole ribonucleotide mutaseUniRule annotation |
Gene namesi | Name:purEUniRule annotation Ordered Locus Names:PA5426 |
Organismi | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
Taxonomic identifieri | 208964 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › |
Proteomesi |
|
Organism-specific databases
PseudoCAPi | PA5426 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000074978 | 1 – 163 | N5-carboxyaminoimidazole ribonucleotide mutaseAdd BLAST | 163 |
Proteomic databases
PaxDbi | P72157 |
PRIDEi | P72157 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_094982_2_2_6 |
InParanoidi | P72157 |
OMAi | SNSIDGW |
PhylomeDBi | P72157 |
Family and domain databases
Gene3Di | 3.40.50.7700, 1 hit |
HAMAPi | MF_01929, PurE_classI, 1 hit |
InterProi | View protein in InterPro IPR033747, PurE_ClassI IPR000031, PurE_dom IPR024694, PurE_prokaryotes IPR035893, PurE_sf |
Pfami | View protein in Pfam PF00731, AIRC, 1 hit |
PIRSFi | PIRSF001338, AIR_carboxylase, 1 hit |
SMARTi | View protein in SMART SM01001, AIRC, 1 hit |
SUPFAMi | SSF52255, SSF52255, 1 hit |
TIGRFAMsi | TIGR01162, purE, 1 hit |
i Sequence
Sequence statusi: Complete.
P72157-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSALVGVIMG SKSDWSTLSH TADMLDKLGI PYEVKVVSAH RTPDLLFQYA
60 70 80 90 100
EEAEGRGLEV IIAGAGGAAH LPGMCAAKTH LPVLGVPVQS SMLSGVDSLL
110 120 130 140 150
SIVQMPAGVP VATLAIGKAG AVNAALLSAS ILGAKHPQYH EALKQFRANQ
160
TETVLDNPDP RDA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 46 | L → F in AAB17257 (PubMed:8816818).Curated | 1 | |
Sequence conflicti | 163 | A → E in AAB17257 (PubMed:8816818).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U58364 Genomic DNA Translation: AAB17257.1 AE004091 Genomic DNA Translation: AAG08811.1 |
PIRi | H82967 |
RefSeqi | NP_254113.1, NC_002516.2 WP_003106314.1, NZ_QZGE01000012.1 |
Genome annotation databases
EnsemblBacteriai | AAG08811; AAG08811; PA5426 |
GeneIDi | 45713444 877624 |
KEGGi | pae:PA5426 |
PATRICi | fig|208964.12.peg.5686 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U58364 Genomic DNA Translation: AAB17257.1 AE004091 Genomic DNA Translation: AAG08811.1 |
PIRi | H82967 |
RefSeqi | NP_254113.1, NC_002516.2 WP_003106314.1, NZ_QZGE01000012.1 |
3D structure databases
SMRi | P72157 |
ModBasei | Search... |
Proteomic databases
PaxDbi | P72157 |
PRIDEi | P72157 |
Protocols and materials databases
DNASUi | 877624 |
Genome annotation databases
EnsemblBacteriai | AAG08811; AAG08811; PA5426 |
GeneIDi | 45713444 877624 |
KEGGi | pae:PA5426 |
PATRICi | fig|208964.12.peg.5686 |
Organism-specific databases
PseudoCAPi | PA5426 |
Phylogenomic databases
HOGENOMi | CLU_094982_2_2_6 |
InParanoidi | P72157 |
OMAi | SNSIDGW |
PhylomeDBi | P72157 |
Enzyme and pathway databases
UniPathwayi | UPA00074;UER00943 |
BioCyci | PAER208964:G1FZ6-5553-MONOMER |
Family and domain databases
Gene3Di | 3.40.50.7700, 1 hit |
HAMAPi | MF_01929, PurE_classI, 1 hit |
InterProi | View protein in InterPro IPR033747, PurE_ClassI IPR000031, PurE_dom IPR024694, PurE_prokaryotes IPR035893, PurE_sf |
Pfami | View protein in Pfam PF00731, AIRC, 1 hit |
PIRSFi | PIRSF001338, AIR_carboxylase, 1 hit |
SMARTi | View protein in SMART SM01001, AIRC, 1 hit |
SUPFAMi | SSF52255, SSF52255, 1 hit |
TIGRFAMsi | TIGR01162, purE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PURE_PSEAE | |
Accessioni | P72157Primary (citable) accession number: P72157 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | December 8, 2000 | |
Last modified: | December 2, 2020 | |
This is version 122 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families