UniProtKB - P71785 (Y1506_MYCTU)
Protein
Putative methyltransferase Rv1506c
Gene
Rv1506c
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Probably plays a role in host phagosome maturation arrest, as well as a role in the synthesis of acyltrehalose-containing glycolipids (PubMed:20844580).1 Publication
GO - Molecular functioni
- methyltransferase activity Source: UniProtKB-KW
GO - Biological processi
- glycolipid biosynthetic process Source: MTBBASE
- negative regulation by symbiont of host innate immune response Source: MTBBASE
Keywordsi
Molecular function | Methyltransferase, Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-5692-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Ordered Locus Names:Rv1506c |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv1506c |
Pathology & Biotechi
Disruption phenotypei
Grows normally in liquid culture, traffics into host (human and mouse) acidified compartments early after phagocytosis, suggesting it no longer arrests phagosome maturation as well as wild-type, impaired growth in mouse macrophages (PubMed:20844580). Decreased synthesis of 2,3-di-O-acyltrehaloses (DAT) and increased synthesis of sulfoglycolipids (SGL) (PubMed:20844580). Decreased colonization of mouse lung but not spleen 42 days after infection (PubMed:20844580).1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000438346 | 1 – 166 | Putative methyltransferase Rv1506cAdd BLAST | 166 |
Proteomic databases
PaxDbi | P71785 |
Family & Domainsi
Sequence similaritiesi
Belongs to the methyltransferase superfamily.Curated
Phylogenomic databases
HOGENOMi | HOG000220958 |
OMAi | IGIDIMP |
PhylomeDBi | P71785 |
Family and domain databases
InterProi | View protein in InterPro IPR041698 Methyltransf_25 IPR029063 SAM-dependent_MTases |
Pfami | View protein in Pfam PF13649 Methyltransf_25, 1 hit |
SUPFAMi | SSF53335 SSF53335, 1 hit |
i Sequence
Sequence statusi: Complete.
P71785-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRIVNAADPF SINDLGCGYG ALLDYLDARG FKTDYTGIDV SPEMVRAAAL
60 70 80 90 100
RFEGRANADF ICAARIDREA DYSVASGIFN VRLKSLDTEW CAHIEATLDM
110 120 130 140 150
LNAASRRGFS FNCLTSYSDA SKMRDDLYYA DPCALFDLCK RRYSKSVALL
160
HDYGLYEFTI LVRKAS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44268.1 |
RefSeqi | NP_216022.1, NC_000962.3 WP_003902091.1, NZ_NVQJ01000004.1 |
Genome annotation databases
EnsemblBacteriai | CCP44268; CCP44268; Rv1506c |
GeneIDi | 886479 |
KEGGi | mtu:Rv1506c mtv:RVBD_1506c |
PATRICi | fig|83332.111.peg.1678 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44268.1 |
RefSeqi | NP_216022.1, NC_000962.3 WP_003902091.1, NZ_NVQJ01000004.1 |
3D structure databases
SMRi | P71785 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv1506c |
Proteomic databases
PaxDbi | P71785 |
Genome annotation databases
EnsemblBacteriai | CCP44268; CCP44268; Rv1506c |
GeneIDi | 886479 |
KEGGi | mtu:Rv1506c mtv:RVBD_1506c |
PATRICi | fig|83332.111.peg.1678 |
Organism-specific databases
TubercuListi | Rv1506c |
Phylogenomic databases
HOGENOMi | HOG000220958 |
OMAi | IGIDIMP |
PhylomeDBi | P71785 |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-5692-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR041698 Methyltransf_25 IPR029063 SAM-dependent_MTases |
Pfami | View protein in Pfam PF13649 Methyltransf_25, 1 hit |
SUPFAMi | SSF53335 SSF53335, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Y1506_MYCTU | |
Accessioni | P71785Primary (citable) accession number: P71785 Secondary accession number(s): F2GEJ7, I6XBN0, L0T9U1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 30, 2016 |
Last sequence update: | July 1, 1997 | |
Last modified: | May 8, 2019 | |
This is version 114 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names