UniProtKB - P71745 (P71745_MYCTU)
Protein
Sulfate transport system permease protein CysT
Gene
cysT
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.UniRule annotation
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
GO - Molecular functioni
- ATPase-coupled sulfate transmembrane transporter activity Source: UniProtKB-UniRule
GO - Biological processi
- sulfate assimilation Source: Reactome
Keywordsi
Biological process | Sulfate transportUniRule annotationARBA annotation, Transport |
Enzyme and pathway databases
Reactomei | R-MTU-936635, Sulfate assimilation |
Protein family/group databases
TCDBi | 3.A.1.6.3, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Sulfate transport system permease protein CysTUniRule annotation |
Gene namesi | Name:cysTImported Ordered Locus Names:Rv2399cImported |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv2399c |
Subcellular locationi
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 32 – 52 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 72 – 98 | HelicalUniRule annotationAdd BLAST | 27 | |
Transmembranei | 110 – 132 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 144 – 168 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 189 – 210 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 250 – 271 | HelicalUniRule annotationAdd BLAST | 22 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-UniRule
- plasma membrane Source: GO_Central
Keywords - Cellular componenti
MembraneInteractioni
Subunit structurei
The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).
ARBA annotationProtein-protein interaction databases
STRINGi | 83332.Rv2399c |
Family & Domainsi
Sequence similaritiesi
Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
eggNOGi | COG0555, Bacteria |
OMAi | VFISGNM |
Family and domain databases
CDDi | cd06261, TM_PBP2, 1 hit |
Gene3Di | 1.10.3720.10, 1 hit |
InterProi | View protein in InterPro IPR011865, CysT_permease IPR000515, MetI-like IPR035906, MetI-like_sf IPR005667, Sulph_transpt2 |
PANTHERi | PTHR30406, PTHR30406, 1 hit PTHR30406:SF8, PTHR30406:SF8, 1 hit |
Pfami | View protein in Pfam PF00528, BPD_transp_1, 1 hit |
SUPFAMi | SSF161098, SSF161098, 1 hit |
TIGRFAMsi | TIGR00969, 3a0106s02, 1 hit TIGR02139, permease_CysT, 1 hit |
PROSITEi | View protein in PROSITE PS50928, ABC_TM1, 1 hit |
i Sequence
Sequence statusi: Complete.
P71745-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTESLVGERR APQFRARLSG PAGPPSVRVG MAVVWLSVIV LLPLAAIVWQ
60 70 80 90 100
AAGGGWRAFW LAVSSHAAME SFRVTLTIST AVTVINLVFG LLIAWVLVRD
110 120 130 140 150
DFAGKRIVDA IIDLPFALPT IVASLVMLAL YGNNSPVGLH FQHTATGVGV
160 170 180 190 200
ALAFVTLPFV VRAVQPVLLE IDRETEEAAA SLGANGAKIF TSVVLPSLTP
210 220 230 240 250
ALLSGAGLAF SRAIGEFGSV VLIGGAVPGK TEVSSQWIRT LIENDDRTGA
260 270 280
AAISVVLLSI SFIVLLILRV VGARAAKREE MAA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP45189.1 |
RefSeqi | NP_216915.1, NC_000962.3 WP_003412332.1, NZ_NVQJ01000054.1 |
Genome annotation databases
EnsemblBacteriai | AIR15162; AIR15162; LH57_13100 CCP45189; CCP45189; Rv2399c |
GeneIDi | 45426387 885301 |
KEGGi | mtu:Rv2399c |
PATRICi | fig|83332.111.peg.2678 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP45189.1 |
RefSeqi | NP_216915.1, NC_000962.3 WP_003412332.1, NZ_NVQJ01000054.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 83332.Rv2399c |
Protein family/group databases
TCDBi | 3.A.1.6.3, the atp-binding cassette (abc) superfamily |
Proteomic databases
PaxDbi | P71745 |
Genome annotation databases
EnsemblBacteriai | AIR15162; AIR15162; LH57_13100 CCP45189; CCP45189; Rv2399c |
GeneIDi | 45426387 885301 |
KEGGi | mtu:Rv2399c |
PATRICi | fig|83332.111.peg.2678 |
Organism-specific databases
TubercuListi | Rv2399c |
Phylogenomic databases
eggNOGi | COG0555, Bacteria |
OMAi | VFISGNM |
Enzyme and pathway databases
Reactomei | R-MTU-936635, Sulfate assimilation |
Family and domain databases
CDDi | cd06261, TM_PBP2, 1 hit |
Gene3Di | 1.10.3720.10, 1 hit |
InterProi | View protein in InterPro IPR011865, CysT_permease IPR000515, MetI-like IPR035906, MetI-like_sf IPR005667, Sulph_transpt2 |
PANTHERi | PTHR30406, PTHR30406, 1 hit PTHR30406:SF8, PTHR30406:SF8, 1 hit |
Pfami | View protein in Pfam PF00528, BPD_transp_1, 1 hit |
SUPFAMi | SSF161098, SSF161098, 1 hit |
TIGRFAMsi | TIGR00969, 3a0106s02, 1 hit TIGR02139, permease_CysT, 1 hit |
PROSITEi | View protein in PROSITE PS50928, ABC_TM1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | P71745_MYCTU | |
Accessioni | P71745Primary (citable) accession number: P71745 Secondary accession number(s): F2GI49, I6Y0M6, Q7D775 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 1, 1997 |
Last sequence update: | February 1, 1997 | |
Last modified: | February 10, 2021 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |