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UniProtKB - P71403 (CHEY1_HELPY)
Protein
Chemotaxis protein CheY1
Gene
cheY1
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Functioni
Chemotactic response regulator protein that modulates the rotation direction of bacterial flagellar motors. Plays an important role in the colonization and infection of Helicobacter pylori (PubMed:10722597).
Upon phosphorylation by CheA, interacts with the flagellar motor protein FliM to cause clockwise flagellar rotation and bacterial reversals, as opposed to straight swimming when CheY1 is not phosphorylated (PubMed:20207758).
2 PublicationsCofactori
Mg2+1 PublicationNote: Binds 1 Mg2+ ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 8 | MagnesiumCombined sources | 1 | |
Metal bindingi | 53 | MagnesiumCombined sources | 1 | |
Metal bindingi | 55 | Magnesium; via carbonyl oxygenCombined sources | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- archaeal or bacterial-type flagellum-dependent cell motility Source: UniProtKB-KW
- chemotaxis Source: UniProtKB-KW
- phosphorelay signal transduction system Source: UniProtKB-KW
Keywordsi
Biological process | Chemotaxis, Flagellar rotation, Two-component regulatory system |
Ligand | Magnesium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Chemotaxis protein CheY11 Publication |
Gene namesi | Name:cheY11 Publication Ordered Locus Names:HP_1067 |
Organismi | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) |
Taxonomic identifieri | 85962 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm Curated
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081050 | 1 – 124 | Chemotaxis protein CheY1Add BLAST | 124 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 53 | 4-aspartylphosphatePROSITE-ProRule annotation1 Publication | 1 |
Post-translational modificationi
Phosphorylated by CheAY (PubMed:16207913). Dephosphorylated (inactivated) by CheZ (PubMed:16207913, PubMed:20497335).2 Publications
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P71403 |
Interactioni
Subunit structurei
Interacts (when phosphorylated) with FliM.
1 PublicationBinary interactionsi
P71403
With | #Exp. | IntAct |
---|---|---|
cheAY [O25153] | 3 | EBI-6409045,EBI-6410665 |
Protein-protein interaction databases
DIPi | DIP-3256N |
IntActi | P71403, 4 interactors |
MINTi | P71403 |
STRINGi | 85962.C694_05515 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P71403 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P71403 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 120 | Response regulatoryPROSITE-ProRule annotationAdd BLAST | 119 |
Phylogenomic databases
eggNOGi | COG0745, Bacteria |
OMAi | AAGAHEY |
PhylomeDBi | P71403 |
Family and domain databases
InterProi | View protein in InterPro IPR011006, CheY-like_superfamily IPR001789, Sig_transdc_resp-reg_receiver |
Pfami | View protein in Pfam PF00072, Response_reg, 1 hit |
SMARTi | View protein in SMART SM00448, REC, 1 hit |
SUPFAMi | SSF52172, SSF52172, 1 hit |
PROSITEi | View protein in PROSITE PS50110, RESPONSE_REGULATORY, 1 hit |
i Sequence
Sequence statusi: Complete.
P71403-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLLVVDDSS TMRRIIKNTL SRLGYEDVLE AEHGVEAWEK LDANADTKVL
60 70 80 90 100
ITDWNMPEMN GLDLVKKVRS DSRFKEIPII MITTEGGKAE VITALKAGVN
110 120
NYIVKPFTPQ VLKEKLEVVL GTND
Sequence cautioni
The sequence CAA57487 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 122 | T → A in strain: NCTC 11637 and NCTC 11638. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X81897 Genomic DNA Translation: CAA57487.1 Different initiation. U97567 Genomic DNA Translation: AAB66375.1 AE000511 Genomic DNA Translation: AAD08113.1 AF021090 Genomic DNA Translation: AAD01682.1 |
PIRi | C64653 |
RefSeqi | NP_207858.1, NC_000915.1 WP_000772151.1, NC_018939.1 |
Genome annotation databases
EnsemblBacteriai | AAD08113; AAD08113; HP_1067 |
KEGGi | hpy:HP_1067 |
PATRICi | fig|85962.47.peg.1146 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X81897 Genomic DNA Translation: CAA57487.1 Different initiation. U97567 Genomic DNA Translation: AAB66375.1 AE000511 Genomic DNA Translation: AAD08113.1 AF021090 Genomic DNA Translation: AAD01682.1 |
PIRi | C64653 |
RefSeqi | NP_207858.1, NC_000915.1 WP_000772151.1, NC_018939.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3GWG | X-ray | 1.80 | A | 1-124 | [»] | |
3H1E | X-ray | 2.40 | A | 1-124 | [»] | |
3H1F | X-ray | 2.20 | A | 1-124 | [»] | |
3H1G | X-ray | 1.70 | A | 1-124 | [»] | |
SMRi | P71403 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-3256N |
IntActi | P71403, 4 interactors |
MINTi | P71403 |
STRINGi | 85962.C694_05515 |
Proteomic databases
PaxDbi | P71403 |
Genome annotation databases
EnsemblBacteriai | AAD08113; AAD08113; HP_1067 |
KEGGi | hpy:HP_1067 |
PATRICi | fig|85962.47.peg.1146 |
Phylogenomic databases
eggNOGi | COG0745, Bacteria |
OMAi | AAGAHEY |
PhylomeDBi | P71403 |
Miscellaneous databases
EvolutionaryTracei | P71403 |
Family and domain databases
InterProi | View protein in InterPro IPR011006, CheY-like_superfamily IPR001789, Sig_transdc_resp-reg_receiver |
Pfami | View protein in Pfam PF00072, Response_reg, 1 hit |
SMARTi | View protein in SMART SM00448, REC, 1 hit |
SUPFAMi | SSF52172, SSF52172, 1 hit |
PROSITEi | View protein in PROSITE PS50110, RESPONSE_REGULATORY, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CHEY1_HELPY | |
Accessioni | P71403Primary (citable) accession number: P71403 Secondary accession number(s): O07677 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 128 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references