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Protein
Submitted name:

Pentaerythritol tetranitrate reductase

Gene

onr

Organism
Enterobacter cloacae
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei27NADCombined sources1
Binding sitei59FMN; via amide nitrogenCombined sources1
Binding sitei69NADCombined sources1
Binding sitei69ProgesteroneCombined sources1
Binding sitei101FMNCombined sources1
Binding sitei143ProgesteroneCombined sources1
Binding sitei182FMNCombined sources1
Binding sitei234FMNCombined sources1
Binding sitei242NADCombined sources1
Binding sitei275NADCombined sources1
Binding sitei325NADCombined sources1
Binding sitei348NADCombined sources1
Binding sitei352FMNCombined sources1
Binding sitei352NADCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi25 – 27FMNCombined sources3
Nucleotide bindingi182 – 185NADCombined sources4
Nucleotide bindingi302 – 303FMNCombined sources2
Nucleotide bindingi324 – 325FMNCombined sources2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandFlavoprotein, FMNCombined sources, NADCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P71278

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Pentaerythritol tetranitrate reductaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:onrImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEnterobacter cloacaeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri550 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEnterobacterEnterobacter cloacae complex

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB04528 2,4-Dinitrophenol
DB07373 ANDROSTA-1,4-DIENE-3,17-DIONE
DB02060 Cyclohexanone
DB03247 Flavin mononucleotide
DB02508 Isopentyl Pyrophosphate
DB03651 Picric acid
DB11090 Potassium nitrate
DB01676 Trinitrotoluene

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GVOX-ray1.38A2-365[»]
1GVQX-ray2.00A2-365[»]
1GVRX-ray1.38A2-365[»]
1GVSX-ray1.38A2-365[»]
1H50X-ray1.50A2-365[»]
1H51X-ray1.60A2-365[»]
1H60X-ray1.60A2-365[»]
1H61X-ray1.40A2-365[»]
1H62X-ray1.90A2-365[»]
1H63X-ray1.62A2-365[»]
1VYPX-ray1.27X2-365[»]
1VYRX-ray0.90A2-365[»]
1VYSX-ray1.80X2-365[»]
2ABAX-ray1.05A2-365[»]
2ABBX-ray1.00A2-365[»]
3F03X-ray1.34K2-365[»]
3KFTX-ray2.10A/B2-365[»]
3P62X-ray1.40A1-365[»]
3P67X-ray1.50A1-365[»]
3P74X-ray1.20A1-365[»]
3P7YX-ray1.20A1-365[»]
3P80X-ray1.20A1-365[»]
3P81X-ray1.20A1-365[»]
3P82X-ray2.20A1-365[»]
3P84X-ray1.10A1-365[»]
3P8IX-ray1.19A1-365[»]
3P8JX-ray1.00A1-365[»]
5LGXX-ray1.50A3-365[»]
5LGZX-ray1.50A3-365[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P71278

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P71278

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P71278

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 344Oxidored_FMNInterPro annotationAdd BLAST340

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni182 – 185Progesterone bindingCombined sources4

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105CCY Bacteria
COG1902 LUCA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013785 Aldolase_TIM
IPR001155 OxRdtase_FMN_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00724 Oxidored_FMN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P71278-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAEKLFTPL KVGAVTAPNR VFMAPLTRLR SIEPGDIPTP LMGEYYRQRA
60 70 80 90 100
SAGLIISEAT QISAQAKGYA GAPGLHSPEQ IAAWKKITAG VHAEDGRIAV
110 120 130 140 150
QLWHTGRISH SSIQPGGQAP VSASALNANT RTSLRDENGN AIRVDTTTPR
160 170 180 190 200
ALELDEIPGI VNDFRQAVAN AREAGFDLVE LHSAHGYLLH QFLSPSSNQR
210 220 230 240 250
TDQYGGSVEN RARLVLEVVD AVCNEWSADR IGIRVSPIGT FQNVDNGPNE
260 270 280 290 300
EADALYLIEE LAKRGIAYLH MSETDLAGGK PYSEAFRQKV RERFHGVIIG
310 320 330 340 350
AGAYTAEKAE DLIGKGLIDA VAFGRDYIAN PDLVARLQKK AELNPQRPES
360
FYGGGAEGYT DYPSL
Length:365
Mass (Da):39,489
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2B34CB1E960AC648
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U68759 Genomic DNA Translation: AAB38683.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68759 Genomic DNA Translation: AAB38683.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GVOX-ray1.38A2-365[»]
1GVQX-ray2.00A2-365[»]
1GVRX-ray1.38A2-365[»]
1GVSX-ray1.38A2-365[»]
1H50X-ray1.50A2-365[»]
1H51X-ray1.60A2-365[»]
1H60X-ray1.60A2-365[»]
1H61X-ray1.40A2-365[»]
1H62X-ray1.90A2-365[»]
1H63X-ray1.62A2-365[»]
1VYPX-ray1.27X2-365[»]
1VYRX-ray0.90A2-365[»]
1VYSX-ray1.80X2-365[»]
2ABAX-ray1.05A2-365[»]
2ABBX-ray1.00A2-365[»]
3F03X-ray1.34K2-365[»]
3KFTX-ray2.10A/B2-365[»]
3P62X-ray1.40A1-365[»]
3P67X-ray1.50A1-365[»]
3P74X-ray1.20A1-365[»]
3P7YX-ray1.20A1-365[»]
3P80X-ray1.20A1-365[»]
3P81X-ray1.20A1-365[»]
3P82X-ray2.20A1-365[»]
3P84X-ray1.10A1-365[»]
3P8IX-ray1.19A1-365[»]
3P8JX-ray1.00A1-365[»]
5LGXX-ray1.50A3-365[»]
5LGZX-ray1.50A3-365[»]
ProteinModelPortaliP71278
SMRiP71278
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

DrugBankiDB04528 2,4-Dinitrophenol
DB07373 ANDROSTA-1,4-DIENE-3,17-DIONE
DB02060 Cyclohexanone
DB03247 Flavin mononucleotide
DB02508 Isopentyl Pyrophosphate
DB03651 Picric acid
DB11090 Potassium nitrate
DB01676 Trinitrotoluene

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105CCY Bacteria
COG1902 LUCA

Enzyme and pathway databases

SABIO-RKiP71278

Miscellaneous databases

EvolutionaryTraceiP71278

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001155 OxRdtase_FMN_N
PfamiView protein in Pfam
PF00724 Oxidored_FMN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP71278_ENTCL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P71278
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: January 16, 2019
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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