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Protein

HTH-type transcriptional activator mta

Gene

mta

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Global transcriptional regulator that activates transcription of bmr and blt by binding directly to their promoter. Stimulates also the expression of the mta gene itself, ydfK and ymfE.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi5 – 24H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciBSUB:BSU36600-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional activator mta
Alternative name(s):
Multidrug transporter activation protein
Gene namesi
Name:mta
Synonyms:ywnD
Ordered Locus Names:BSU36600
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003549741 – 257HTH-type transcriptional activator mtaAdd BLAST257

Proteomic databases

PaxDbiP71039
PRIDEiP71039

Expressioni

Inductioni

Autoregulated.1 Publication

Interactioni

Subunit structurei

Homodimer.2 Publications

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100019786

Structurei

Secondary structure

1257
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 12Combined sources8
Helixi16 – 24Combined sources9
Beta strandi31 – 33Combined sources3
Beta strandi39 – 41Combined sources3
Helixi43 – 57Combined sources15
Helixi62 – 70Combined sources9
Helixi76 – 105Combined sources30

3D structure databases

ProteinModelPortaliP71039
SMRiP71039
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP71039

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 71HTH merR-typePROSITE-ProRule annotationAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni71 – 74Hinge4
Regioni76 – 104Essential for dimerizationAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili76 – 107Add BLAST32

Domaini

The central dimerization domain of the first subunit forms a two-helix antiparallel coiled coil with the dimerization domain of the second subunit.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG4107TXC Bacteria
COG0789 LUCA
HOGENOMiHOG000240261
InParanoidiP71039
KOiK21743
OMAiMYVSDER
PhylomeDBiP71039

Family and domain databases

Gene3Di1.10.490.50, 1 hit
InterProiView protein in InterPro
IPR009061 DNA-bd_dom_put_sf
IPR000551 MerR-type_HTH_dom
IPR036244 TipA-like_antibiotic-bd
IPR012925 TipAS_dom
PfamiView protein in Pfam
PF13411 MerR_1, 1 hit
PF07739 TipAS, 1 hit
PRINTSiPR00040 HTHMERR
SMARTiView protein in SMART
SM00422 HTH_MERR, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
SSF89082 SSF89082, 1 hit
PROSITEiView protein in PROSITE
PS50937 HTH_MERR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P71039-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYQVKQVAE ISGVSIRTLH HYDNIELLNP SALTDAGYRL YSDADLERLQ
60 70 80 90 100
QILFFKEIGF RLDEIKEMLD HPNFDRKAAL QSQKEILMKK KQRMDEMIQT
110 120 130 140 150
IDRTLLSVDG GETMNKRDLF AGLSMKDIEE HQQTYADEVR KLYGKEIAEE
160 170 180 190 200
TEKRTSAYSA DDWRTIMAEF DSIYRRIAAR MKHGPDDAEI QAAVGAFRDH
210 220 230 240 250
ICQYHYDCTL DIFRGLGEVY ITDERFTDSI NQYGEGLAAF LREAIIIYCD

HQENPRP
Length:257
Mass (Da):29,936
Last modified:February 1, 1997 - v1
Checksum:i98AD46A5CED91DB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08559 Genomic DNA Translation: CAA69863.1
AL009126 Genomic DNA Translation: CAB15677.1
PIRiC69661
RefSeqiNP_391541.1, NC_000964.3
WP_003242936.1, NZ_JNCM01000034.1

Genome annotation databases

EnsemblBacteriaiCAB15677; CAB15677; BSU36600
GeneIDi936962
KEGGibsu:BSU36600
PATRICifig|224308.179.peg.3961

Similar proteinsi

Entry informationi

Entry nameiMTA_BACSU
AccessioniPrimary (citable) accession number: P71039
Secondary accession number(s): Q794Z9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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