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Entry version 125 (07 Apr 2021)
Sequence version 1 (01 Feb 1997)
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Protein

Antilisterial bacteriocin subtilosin biosynthesis protein AlbA

Gene

albA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the formation of 3 thioether bonds during production of the sactipeptide subtilosin from SboA. In vitro the thioether bonds cannot be made in the absence of the SboA propeptide, suggesting this is the first reaction in subtilosin maturation (PubMed:22366720). In vitro, in the absence of a second substrate, cleaves S-adenosyl-L-methionine into Met and 5'-dA (PubMed:22366720).3 Publications

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] cluster1 PublicationNote: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine, the other is coordinated via 3 cysteines and maybe direct contact with the SboA precursor.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi129Iron-sulfur (4Fe-4S-S-AdoMet)1 Publication1
Metal bindingi133Iron-sulfur (4Fe-4S-S-AdoMet)1 Publication1
Metal bindingi136Iron-sulfur (4Fe-4S-S-AdoMet)1 Publication1
Metal bindingi408Iron-sulfur (4Fe-4S-S-substrate)1 Publication1
Metal bindingi414Iron-sulfur (4Fe-4S-S-substrate)1 Publication1
Metal bindingi417Iron-sulfur (4Fe-4S-S-substrate)1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processAntibiotic biosynthesis, Bacteriocin biosynthesis
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BSUB:BSU37370-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Antilisterial bacteriocin subtilosin biosynthesis protein AlbA (EC:1.21.98.-1 Publication)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:albA
Synonyms:ywiA
Ordered Locus Names:BSU37370
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus subtilis (strain 168)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224308 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001570 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi129 – 136CNLKCAHC → ANLKAAHA: No longer cleaves SAM, does not make thioether bonds, contains 68% iron of wild-type. 1 Publication8
Mutagenesisi408 – 417CPFSGYCGGC → APFSGYAGGA: Weakly cleaves SAM but does not make thioether bonds, contains 68% iron of wild-type. 1 Publication10

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000645421 – 448Antilisterial bacteriocin subtilosin biosynthesis protein AlbAAdd BLAST448

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P71011

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P71011

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Transcription is highly induced by oxygen limitation and is under dual and independent control of Spo0A-AbrB and ResDE.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
224308.BSU37370

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P71011

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini115 – 329Radical SAM corePROSITE-ProRule annotationAdd BLAST215

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0535, Bacteria

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P71011

Identification of Orthologs from Complete Genome Data

More...
OMAi
GFCFISH

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P71011

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023885, 4Fe4S-binding_SPASM_dom
IPR013785, Aldolase_TIM
IPR006638, Elp3/MiaB/NifB
IPR008792, PQQD
IPR007197, rSAM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05402, PqqD, 1 hit
PF04055, Radical_SAM, 1 hit
PF13186, SPASM, 1 hit

Structure-Function Linkage Database

More...
SFLDi
SFLDS00029, Radical_SAM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00729, Elp3, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR04085, rSAM_more_4Fe4S, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51918, RADICAL_SAM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P71011-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFIEQMFPFI NESVRVHQLP EGGVLEIDYL RDNVSISDFE YLDLNKTAYE
60 70 80 90 100
LCMRMDGQKT AEQILAEQCA VYDESPEDHK DWYYDMLNML QNKQVIQLGN
110 120 130 140 150
RASRHTITTS GSNEFPMPLH ATFELTHRCN LKCAHCYLES SPEALGTVSI
160 170 180 190 200
EQFKKTADML FDNGVLTCEI TGGEIFVHPN ANEILDYVCK KFKKVAVLTN
210 220 230 240 250
GTLMRKESLE LLKTYKQKII VGISLDSVNS EVHDSFRGRK GSFAQTCKTI
260 270 280 290 300
KLLSDHGIFV RVAMSVFEKN MWEIHDMAQK VRDLGAKAFS YNWVDDFGRG
310 320 330 340 350
RDIVHPTKDA EQHRKFMEYE QHVIDEFKDL IPIIPYERKR AANCGAGWKS
360 370 380 390 400
IVISPFGEVR PCALFPKEFS LGNIFHDSYE SIFNSPLVHK LWQAQAPRFS
410 420 430 440
EHCMKDKCPF SGYCGGCYLK GLNSNKYHRK NICSWAKNEQ LEDVVQLI
Length:448
Mass (Da):51,514
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA3247604BC8CCAA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti91Q → L in strain: ATCC 6633. 1
Natural varianti96I → V in strain: ATCC 6633. 1
Natural varianti99 – 108GNRASRHTIT → ENQSTRHAIN in strain: ATCC 6633. 10
Natural varianti214T → A in strain: ATCC 6633. 1
Natural varianti232V → I in strain: ATCC 6633. 1
Natural varianti309D → N in strain: ATCC 6633. 1
Natural varianti322 – 323HV → NI in strain: ATCC 6633. 2
Natural varianti412G → S in strain: ATCC 6633. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ430547 Genomic DNA Translation: CAD23199.1
Z80360 Genomic DNA Translation: CAB02509.1
Z97024 Genomic DNA Translation: CAB09700.1
AL009126 Genomic DNA Translation: CAB15764.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B70059

NCBI Reference Sequences

More...
RefSeqi
NP_391617.1, NC_000964.3
WP_003242599.1, NZ_JNCM01000034.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAB15764; CAB15764; BSU_37370

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
937059

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bsu:BSU37370

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|224308.179.peg.4047

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ430547 Genomic DNA Translation: CAD23199.1
Z80360 Genomic DNA Translation: CAB02509.1
Z97024 Genomic DNA Translation: CAB09700.1
AL009126 Genomic DNA Translation: CAB15764.1
PIRiB70059
RefSeqiNP_391617.1, NC_000964.3
WP_003242599.1, NZ_JNCM01000034.1

3D structure databases

SMRiP71011
ModBaseiSearch...

Protein-protein interaction databases

STRINGi224308.BSU37370

Proteomic databases

jPOSTiP71011
PaxDbiP71011

Genome annotation databases

EnsemblBacteriaiCAB15764; CAB15764; BSU_37370
GeneIDi937059
KEGGibsu:BSU37370
PATRICifig|224308.179.peg.4047

Phylogenomic databases

eggNOGiCOG0535, Bacteria
InParanoidiP71011
OMAiGFCFISH
PhylomeDBiP71011

Enzyme and pathway databases

BioCyciBSUB:BSU37370-MONOMER

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR023885, 4Fe4S-binding_SPASM_dom
IPR013785, Aldolase_TIM
IPR006638, Elp3/MiaB/NifB
IPR008792, PQQD
IPR007197, rSAM
PfamiView protein in Pfam
PF05402, PqqD, 1 hit
PF04055, Radical_SAM, 1 hit
PF13186, SPASM, 1 hit
SFLDiSFLDS00029, Radical_SAM, 1 hit
SMARTiView protein in SMART
SM00729, Elp3, 1 hit
TIGRFAMsiTIGR04085, rSAM_more_4Fe4S, 1 hit
PROSITEiView protein in PROSITE
PS51918, RADICAL_SAM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiALBA_BACSU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P71011
Secondary accession number(s): Q8RKH6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: February 1, 1997
Last modified: April 7, 2021
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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