UniProtKB - P70708 (PADI3_RAT)
Protein
Protein-arginine deiminase type-3
Gene
Padi3
Organism
Rattus norvegicus (Rat)
Status
Functioni
Catalyzes the deimination of arginine residues of proteins.By similarity
Catalytic activityi
- EC:3.5.3.15By similarity
Cofactori
GO - Molecular functioni
- calcium ion binding Source: InterPro
- identical protein binding Source: RGD
- protein-arginine deiminase activity Source: UniProtKB
GO - Biological processi
- arginine deiminase pathway Source: RGD
- histone citrullination Source: GO_Central
- protein citrullination Source: UniProtKB
Keywordsi
Molecular function | Hydrolase |
Ligand | Calcium |
Enzyme and pathway databases
BRENDAi | 3.5.3.15, 5301 |
Reactomei | R-RNO-3247509, Chromatin modifying enzymes |
Names & Taxonomyi
Protein namesi | Recommended name: Protein-arginine deiminase type-3 (EC:3.5.3.15By similarity)Alternative name(s): Peptidylarginine deiminase III Protein-arginine deiminase type III |
Gene namesi | Name:Padi3 Synonyms:Pad3, Pdi3 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3289, Padi3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000220031 | 1 – 664 | Protein-arginine deiminase type-3Add BLAST | 664 |
Proteomic databases
PaxDbi | P70708 |
PTM databases
iPTMneti | P70708 |
PhosphoSitePlusi | P70708 |
Expressioni
Tissue specificityi
Epidermis and hair follicles.
Interactioni
GO - Molecular functioni
- identical protein binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000009230 |
Family & Domainsi
Sequence similaritiesi
Belongs to the protein arginine deiminase family.Curated
Phylogenomic databases
eggNOGi | ENOG502QVJA, Eukaryota |
InParanoidi | P70708 |
OrthoDBi | 787070at2759 |
PhylomeDBi | P70708 |
Family and domain databases
Gene3Di | 2.60.40.1700, 1 hit 2.60.40.1860, 1 hit |
InterProi | View protein in InterPro IPR008972, Cupredoxin IPR004303, PAD IPR013530, PAD_C IPR036556, PAD_central_sf IPR013732, PAD_N IPR038685, PAD_N_sf IPR013733, Prot_Arg_deaminase_cen_dom |
PANTHERi | PTHR10837, PTHR10837, 1 hit |
Pfami | View protein in Pfam PF03068, PAD, 1 hit PF08527, PAD_M, 1 hit PF08526, PAD_N, 1 hit |
PIRSFi | PIRSF001247, Protein-arginine_deiminase, 1 hit |
SUPFAMi | SSF110083, SSF110083, 1 hit SSF49503, SSF49503, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P70708-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLQRTVRVS LEHPTSAVCV AGVETIVDIY GSVPEGTDMF EVYGTPGVDI
60 70 80 90 100
YVSPSMERNR ERADTRRWCF NKGLEIIVVM NSPSNDLNDS HVQIAYHSSH
110 120 130 140 150
EHLPLAYAVL YLTCVDITLD CDMNCADRQD RSFVDKRQWM WGPDGYGAIL
160 170 180 190 200
LVNCDRDEVS SDAQDNCDQC VRCLQDLEDM SVMVLRTQGP ESLFDDHRLI
210 220 230 240 250
LHTSSCDAER ARVFHVCGPE DSCEAYRCVL GPDRMSYEVP RLKGYEERFY
260 270 280 290 300
VEGLSFPDAG FPGILSFHIT LLDDSNEDYS ETPIFTDTVV FRVAPWIMTP
310 320 330 340 350
STLPPLEVYV CQVRNNTCFV EAVEELARKA GCKLTICPQA ENRNDRWIQD
360 370 380 390 400
EMELGYTQAP HKTLPVVFDS PRNGELQGFP YKRILGLDFG YVTREPPDSS
410 420 430 440 450
VSGLDSFGNL EVSPPVVANG KEYPLGRILI GGNLPGSRGR RVTQVVRDFL
460 470 480 490 500
HAQKVQPLVE LFVDWLAVGH VDEFLSFVPA PDGKGFRLLL ASPGACFRLF
510 520 530 540 550
QEKQKWGHGR SLLFEGVIGD RRVQTISINQ VLSNQSLINF NKFAQSCIDW
560 570 580 590 600
NREVLKRELG LGESDIIDIP QLFKSEKRKA VAFFPDLVNM LVLGKHLGIP
610 620 630 640 650
KPFGPIINGR CCLEEKVRSL LEPLGLHCTF IDDFTPYHML HGEVHCGTNV
660
RREPFAFKWW HMVP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V6V2 | G3V6V2_RAT | Protein-arginine deiminase | Padi3 rCG_30972 | 664 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D88034 mRNA Translation: BAA13532.1 |
PIRi | JC5440 |
RefSeqi | NP_058926.1, NM_017230.2 |
Genome annotation databases
GeneIDi | 29520 |
KEGGi | rno:29520 |
UCSCi | RGD:3289, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D88034 mRNA Translation: BAA13532.1 |
PIRi | JC5440 |
RefSeqi | NP_058926.1, NM_017230.2 |
3D structure databases
SMRi | P70708 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000009230 |
PTM databases
iPTMneti | P70708 |
PhosphoSitePlusi | P70708 |
Proteomic databases
PaxDbi | P70708 |
Genome annotation databases
GeneIDi | 29520 |
KEGGi | rno:29520 |
UCSCi | RGD:3289, rat |
Organism-specific databases
CTDi | 51702 |
RGDi | 3289, Padi3 |
Phylogenomic databases
eggNOGi | ENOG502QVJA, Eukaryota |
InParanoidi | P70708 |
OrthoDBi | 787070at2759 |
PhylomeDBi | P70708 |
Enzyme and pathway databases
BRENDAi | 3.5.3.15, 5301 |
Reactomei | R-RNO-3247509, Chromatin modifying enzymes |
Miscellaneous databases
PROi | PR:P70708 |
Family and domain databases
Gene3Di | 2.60.40.1700, 1 hit 2.60.40.1860, 1 hit |
InterProi | View protein in InterPro IPR008972, Cupredoxin IPR004303, PAD IPR013530, PAD_C IPR036556, PAD_central_sf IPR013732, PAD_N IPR038685, PAD_N_sf IPR013733, Prot_Arg_deaminase_cen_dom |
PANTHERi | PTHR10837, PTHR10837, 1 hit |
Pfami | View protein in Pfam PF03068, PAD, 1 hit PF08527, PAD_M, 1 hit PF08526, PAD_N, 1 hit |
PIRSFi | PIRSF001247, Protein-arginine_deiminase, 1 hit |
SUPFAMi | SSF110083, SSF110083, 1 hit SSF49503, SSF49503, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PADI3_RAT | |
Accessioni | P70708Primary (citable) accession number: P70708 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | February 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families