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Protein

Protein-arginine deiminase type-3

Gene

Padi3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the deimination of arginine residues of proteins.By similarity

Catalytic activityi

Protein L-arginine + H2O = protein L-citrulline + NH3.By similarity

Cofactori

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • protein-arginine deiminase activity Source: UniProtKB

GO - Biological processi

  • arginine deiminase pathway Source: RGD
  • histone citrullination Source: GO_Central
  • protein citrullination Source: UniProtKB

Keywordsi

Molecular functionHydrolase
LigandCalcium

Enzyme and pathway databases

BRENDAi3.5.3.15 5301

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-arginine deiminase type-3 (EC:3.5.3.15By similarity)
Alternative name(s):
Peptidylarginine deiminase III
Protein-arginine deiminase type III
Gene namesi
Name:Padi3
Synonyms:Pad3, Pdi3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3289 Padi3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002200311 – 664Protein-arginine deiminase type-3Add BLAST664

Proteomic databases

PaxDbiP70708
PRIDEiP70708

PTM databases

iPTMnetiP70708
PhosphoSitePlusiP70708

Expressioni

Tissue specificityi

Epidermis and hair follicles.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009230

Structurei

3D structure databases

ProteinModelPortaliP70708
SMRiP70708
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein arginine deiminase family.Curated

Phylogenomic databases

eggNOGiENOG410IF3F Eukaryota
ENOG410ZKF3 LUCA
HOGENOMiHOG000220908
HOVERGENiHBG053016
InParanoidiP70708
KOiK01481
PhylomeDBiP70708

Family and domain databases

Gene3Di2.60.40.1700, 1 hit
2.60.40.1860, 1 hit
InterProiView protein in InterPro
IPR008972 Cupredoxin
IPR004303 PAD
IPR013530 PAD_C
IPR036556 PAD_central_sf
IPR013732 PAD_N
IPR038685 PAD_N_sf
IPR013733 Prot_Arg_deaminase_cen_dom
PANTHERiPTHR10837 PTHR10837, 1 hit
PfamiView protein in Pfam
PF03068 PAD, 1 hit
PF08527 PAD_M, 1 hit
PF08526 PAD_N, 1 hit
PIRSFiPIRSF001247 Protein-arginine_deiminase, 1 hit
SUPFAMiSSF110083 SSF110083, 1 hit
SSF49503 SSF49503, 1 hit

Sequencei

Sequence statusi: Complete.

P70708-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQRTVRVS LEHPTSAVCV AGVETIVDIY GSVPEGTDMF EVYGTPGVDI
60 70 80 90 100
YVSPSMERNR ERADTRRWCF NKGLEIIVVM NSPSNDLNDS HVQIAYHSSH
110 120 130 140 150
EHLPLAYAVL YLTCVDITLD CDMNCADRQD RSFVDKRQWM WGPDGYGAIL
160 170 180 190 200
LVNCDRDEVS SDAQDNCDQC VRCLQDLEDM SVMVLRTQGP ESLFDDHRLI
210 220 230 240 250
LHTSSCDAER ARVFHVCGPE DSCEAYRCVL GPDRMSYEVP RLKGYEERFY
260 270 280 290 300
VEGLSFPDAG FPGILSFHIT LLDDSNEDYS ETPIFTDTVV FRVAPWIMTP
310 320 330 340 350
STLPPLEVYV CQVRNNTCFV EAVEELARKA GCKLTICPQA ENRNDRWIQD
360 370 380 390 400
EMELGYTQAP HKTLPVVFDS PRNGELQGFP YKRILGLDFG YVTREPPDSS
410 420 430 440 450
VSGLDSFGNL EVSPPVVANG KEYPLGRILI GGNLPGSRGR RVTQVVRDFL
460 470 480 490 500
HAQKVQPLVE LFVDWLAVGH VDEFLSFVPA PDGKGFRLLL ASPGACFRLF
510 520 530 540 550
QEKQKWGHGR SLLFEGVIGD RRVQTISINQ VLSNQSLINF NKFAQSCIDW
560 570 580 590 600
NREVLKRELG LGESDIIDIP QLFKSEKRKA VAFFPDLVNM LVLGKHLGIP
610 620 630 640 650
KPFGPIINGR CCLEEKVRSL LEPLGLHCTF IDDFTPYHML HGEVHCGTNV
660
RREPFAFKWW HMVP
Length:664
Mass (Da):75,038
Last modified:February 1, 1997 - v1
Checksum:iE5E6DDBCFADC66F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88034 mRNA Translation: BAA13532.1
PIRiJC5440
RefSeqiNP_058926.1, NM_017230.2
UniGeneiRn.32094

Genome annotation databases

GeneIDi29520
KEGGirno:29520
UCSCiRGD:3289 rat

Similar proteinsi

Entry informationi

Entry nameiPADI3_RAT
AccessioniPrimary (citable) accession number: P70708
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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