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Entry version 175 (08 May 2019)
Sequence version 1 (01 Feb 1997)
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Protein

Copper-transporting ATPase 1

Gene

Atp7a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei10364-aspartylphosphate intermediateBy similarity1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1293MagnesiumPROSITE-ProRule annotation1
Metal bindingi1297MagnesiumPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processCopper transport, Ion transport, Transport
LigandATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.6.3.4 5301

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-6803544 Ion influx/efflux at host-pathogen interface
R-RNO-936837 Ion transport by P-type ATPases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Copper-transporting ATPase 1 (EC:7.2.2.8)
Alternative name(s):
Copper pump 1
Menkes disease-associated protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Atp7a
Synonyms:Mnk
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Rat genome database

More...
RGDi
2179 Atp7a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 645CytoplasmicSequence analysisAdd BLAST645
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei646 – 667HelicalSequence analysisAdd BLAST22
Topological domaini668 – 706ExtracellularSequence analysisAdd BLAST39
Transmembranei707 – 726HelicalSequence analysisAdd BLAST20
Topological domaini727 – 733CytoplasmicSequence analysis7
Transmembranei734 – 754HelicalSequence analysisAdd BLAST21
Topological domaini755 – 773ExtracellularSequence analysisAdd BLAST19
Transmembranei774 – 794HelicalSequence analysisAdd BLAST21
Topological domaini795 – 927CytoplasmicSequence analysisAdd BLAST133
Transmembranei928 – 951HelicalSequence analysisAdd BLAST24
Topological domaini952 – 981ExtracellularSequence analysisAdd BLAST30
Transmembranei982 – 1003HelicalSequence analysisAdd BLAST22
Topological domaini1004 – 1348CytoplasmicSequence analysisAdd BLAST345
Transmembranei1349 – 1366HelicalSequence analysisAdd BLAST18
Topological domaini1367 – 1377ExtracellularSequence analysisAdd BLAST11
Transmembranei1378 – 1397HelicalSequence analysisAdd BLAST20
Topological domaini1398 – 1492CytoplasmicSequence analysisAdd BLAST95

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000463131 – 1492Copper-transporting ATPase 1Add BLAST1492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei152PhosphothreonineBy similarity1
Modified residuei270PhosphoserineBy similarity1
Modified residuei327PhosphothreonineBy similarity1
Modified residuei339PhosphoserineBy similarity1
Modified residuei353PhosphoserineCombined sources1
Modified residuei357PhosphoserineBy similarity1
Modified residuei362PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi678N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1204PhosphothreonineCombined sources1
Modified residuei1422PhosphoserineBy similarity1
Modified residuei1424PhosphoserineBy similarity1
Modified residuei1452PhosphoserineBy similarity1
Modified residuei1455PhosphoserineBy similarity1
Modified residuei1458PhosphoserineBy similarity1
Modified residuei1461PhosphoserineBy similarity1
Modified residuei1465PhosphoserineCombined sources1
Modified residuei1468PhosphoserineBy similarity1
Modified residuei1478PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P70705

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P70705

PRoteomics IDEntifications database

More...
PRIDEi
P70705

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P70705

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P70705

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000061367 Expressed in 9 organ(s), highest expression level in lung

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P70705 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P70705 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Interacts with PDZD11 (By similarity). Interacts with ATOX1 and COMMD1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
P70705, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000063702

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P70705

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini9 – 75HMA 1PROSITE-ProRule annotationAdd BLAST67
Domaini172 – 238HMA 2PROSITE-ProRule annotationAdd BLAST67
Domaini278 – 344HMA 3PROSITE-ProRule annotationAdd BLAST67
Domaini378 – 444HMA 4PROSITE-ProRule annotationAdd BLAST67
Domaini481 – 547HMA 5PROSITE-ProRule annotationAdd BLAST67
Domaini557 – 623HMA 6PROSITE-ProRule annotationAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1478 – 1492PDZD11-bindingBy similarityAdd BLAST15

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1479 – 1480Endocytosis signalBy similarity2

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi356 – 362Poly-Ser7

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal di-leucine, 1479-Leu-Leu-1480, is an endocytic targeting signal which functions in retrieving recycling from the plasma membrane to the TGN. Mutation of the di-leucine signal results in the accumulation of the protein in the plasma membrane (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0207 Eukaryota
COG2217 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159568

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000250397

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P70705

KEGG Orthology (KO)

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KOi
K17686

Identification of Orthologs from Complete Genome Data

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OMAi
KTGYEAR

Database of Orthologous Groups

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OrthoDBi
649559at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P70705

Family and domain databases

Conserved Domains Database

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CDDi
cd00371 HMA, 6 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.1110.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR017969 Heavy-metal-associated_CS
IPR006122 HMA_Cu_ion-bd
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
IPR027256 P-typ_ATPase_IB
IPR001757 P_typ_ATPase

Pfam protein domain database

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Pfami
View protein in Pfam
PF00403 HMA, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55008 SSF55008, 6 hits
SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01525 ATPase-IB_hvy, 1 hit
TIGR01494 ATPase_P-type, 2 hits
TIGR00003 TIGR00003, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
PS01047 HMA_1, 6 hits
PS50846 HMA_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P70705-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPNMDANSI TITVEGMTCI SCVRTIEQQI GKVNGVHHIK VSLEEKSATV
60 70 80 90 100
IYNPKLQTPK TLQEAIDDMG FDALLHNANP LPVLTNTVFL TVTAPLALPW
110 120 130 140 150
DHIQSTLLKT KGVTGVKISP QQRSAVVTII PSVVSANQIV ELVPDLSLDM
160 170 180 190 200
GTQEKKSGTS EEHSTPQAGE VLLKMRVEGM TCHSCTSTIE GKVGKLQGVQ
210 220 230 240 250
RIKVSLDNQE ATIVYQPHLI TAEEIKKQIE AVGFPAFIKK QPKYLKLGAI
260 270 280 290 300
DVERLKSTPV KSSEGSQQKS PAYPSDSAIT FTIDGMHCKS CVSNIESALS
310 320 330 340 350
TLQYVSSIVV SLENRSAIVK YNASLVTPEI LRKAIEAVSP GQYRVSISSE
360 370 380 390 400
VESPTSSPSS SSLQKMPLNL VSQPLTQEVV ININGMTCNS CVQSIEGVIS
410 420 430 440 450
KKPGVKSIHV SLTNSTGTIE YDPLLTSPEP LREAIEDMGF DAVLPADMKE
460 470 480 490 500
PLVVIAQPSL ETPLLPSTTE PENVMTPVQN KCYIQVSGMT CASCVANIER
510 520 530 540 550
NLRREEGIYS VLVALMAGKA EVRYNPAVIQ PRVIAELIRE LGFGAVVMEN
560 570 580 590 600
AGEGNGILEL VVRGMTCASC VHKIESTLTK HKGIFYCSVA LATNKAHIKY
610 620 630 640 650
DPEIIGPRDI IHTIGNLGFE ASLVKKDRSA NHLDHKREIK QWRGSFLVSL
660 670 680 690 700
FFCIPVMGLM IYMMVMDHHL ATLNHNQNMS NEEMINMHSS MFLERQILPG
710 720 730 740 750
LSIMNLLSLL LCLPVQFCGG WYFYIQAYKA LRHKTANMDV LIVLATTIAF
760 770 780 790 800
AYSLVILLVA MYERAKVNPI TFFDTPPMLF VFIALGRWLE HIAKGKTSEA
810 820 830 840 850
LAKLISLQAT EATIVTLNSE NLLLSEEQVD VELVQRGDII KVVPGGKFPV
860 870 880 890 900
DGRVIEGHSM VDESLITGEA MPVAKKPGST VIAGSINQNG SLLIRATHVG
910 920 930 940 950
ADTTLSQIVK LVEEAQTSKA PIQQFADKLS GYFVPFIVLV SIVTLLVWII
960 970 980 990 1000
IGFQNFEIVE AYFPGYNRSI SRTETIIRFA FQASITVLCI ACPCSLGLAT
1010 1020 1030 1040 1050
PTAVMVGTGV GAQNGILIKG GEPLEMAHKV KVVVFDKTGT ITHGTPVVNQ
1060 1070 1080 1090 1100
VKVLVESNKI SRNKILAIVG TAESNSEHPL GAAVTKYCKQ ELDTETLGTC
1110 1120 1130 1140 1150
TDFQVVPGCG ISCKVTNIEG LLHKSNLKIE ENNIKNASLV QIDAINEQSS
1160 1170 1180 1190 1200
PSSSMIIDAH LSNAVNTQQY KVLIGNREWM IRNGLVISND VDESMIEHER
1210 1220 1230 1240 1250
RGRTAVLVTI DDELCGLIAI ADTVKPEAEL AVHILKSMGL EVVLMTGDNS
1260 1270 1280 1290 1300
KTARSIASQV GITKVFAEVL PSHKVAKVKQ LQEEGKRVAM VGDGINDSPA
1310 1320 1330 1340 1350
LAMASVGIAI GTGTDVAIEA ADVVLIRNDL LDVVASIDLS RKTVKRIRIN
1360 1370 1380 1390 1400
FVFALIYNLI GIPIAAGVFL PIGLVLQPWM GSAAMAASSV SVVLSSLFLK
1410 1420 1430 1440 1450
LYRKPTYDNY ELRPRSHTGQ RSPSEISVHV GIDDTSRNSP RLGLLDRIVN
1460 1470 1480 1490
YSRASINSLL SDKRSLNSVV TSEPDKHSLL VGDFREDDDT TL
Length:1,492
Mass (Da):162,093
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i34F75152B105AE9F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A096MJU5A0A096MJU5_RAT
Copper-transporting ATPase 1
Atp7a
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D1MCF1D1MCF1_RAT
Copper-transporting ATPase 1
Atp7a
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U59245 mRNA Translation: AAB06393.1

Protein sequence database of the Protein Information Resource

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PIRi
S46483

NCBI Reference Sequences

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RefSeqi
NP_434690.1, NM_052803.2
XP_006257057.1, XM_006256995.3
XP_008771556.1, XM_008773334.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000080141; ENSRNOP00000071625; ENSRNOG00000061367
ENSRNOT00000091527; ENSRNOP00000073176; ENSRNOG00000061367

Database of genes from NCBI RefSeq genomes

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GeneIDi
24941

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:24941

UCSC genome browser

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UCSCi
RGD:2179 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

Heavy metal - Issue 79 of February 2007

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59245 mRNA Translation: AAB06393.1
PIRiS46483
RefSeqiNP_434690.1, NM_052803.2
XP_006257057.1, XM_006256995.3
XP_008771556.1, XM_008773334.2

3D structure databases

SMRiP70705
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP70705, 1 interactor
STRINGi10116.ENSRNOP00000063702

PTM databases

iPTMnetiP70705
PhosphoSitePlusiP70705

Proteomic databases

jPOSTiP70705
PaxDbiP70705
PRIDEiP70705

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000080141; ENSRNOP00000071625; ENSRNOG00000061367
ENSRNOT00000091527; ENSRNOP00000073176; ENSRNOG00000061367
GeneIDi24941
KEGGirno:24941
UCSCiRGD:2179 rat

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
538
RGDi2179 Atp7a

Phylogenomic databases

eggNOGiKOG0207 Eukaryota
COG2217 LUCA
GeneTreeiENSGT00940000159568
HOGENOMiHOG000250397
InParanoidiP70705
KOiK17686
OMAiKTGYEAR
OrthoDBi649559at2759
PhylomeDBiP70705

Enzyme and pathway databases

BRENDAi3.6.3.4 5301
ReactomeiR-RNO-6803544 Ion influx/efflux at host-pathogen interface
R-RNO-936837 Ion transport by P-type ATPases

Miscellaneous databases

Protein Ontology

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PROi
PR:P70705

Gene expression databases

BgeeiENSRNOG00000061367 Expressed in 9 organ(s), highest expression level in lung
ExpressionAtlasiP70705 baseline and differential
GenevisibleiP70705 RN

Family and domain databases

CDDicd00371 HMA, 6 hits
Gene3Di3.40.1110.10, 1 hit
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR017969 Heavy-metal-associated_CS
IPR006122 HMA_Cu_ion-bd
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
IPR027256 P-typ_ATPase_IB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00403 HMA, 6 hits
SUPFAMiSSF55008 SSF55008, 6 hits
SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01525 ATPase-IB_hvy, 1 hit
TIGR01494 ATPase_P-type, 2 hits
TIGR00003 TIGR00003, 6 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
PS01047 HMA_1, 6 hits
PS50846 HMA_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATP7A_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P70705
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: February 1, 1997
Last modified: May 8, 2019
This is version 175 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
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