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Protein

ATP-sensitive inward rectifier potassium channel 11

Gene

Kcnj11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei160Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity1

GO - Molecular functioni

  • ankyrin binding Source: BHF-UCL
  • ATP-activated inward rectifier potassium channel activity Source: RGD
  • ATP binding Source: Ensembl
  • heat shock protein binding Source: RGD
  • ion channel binding Source: Ensembl
  • protein C-terminus binding Source: RGD

GO - Biological processi

  • cellular response to glucose stimulus Source: RGD
  • cellular response to nicotine Source: RGD
  • cellular response to tumor necrosis factor Source: RGD
  • glucose metabolic process Source: Ensembl
  • negative regulation of insulin secretion Source: Ensembl
  • nervous system process Source: Ensembl
  • positive regulation of cation channel activity Source: RGD
  • positive regulation of protein localization to plasma membrane Source: RGD
  • potassium ion import Source: GO_Central
  • potassium ion transport Source: RGD
  • regulation of membrane potential Source: Ensembl
  • response to ATP Source: Ensembl
  • response to drug Source: RGD
  • response to estradiol Source: RGD
  • response to ischemia Source: RGD
  • response to testosterone Source: RGD

Keywordsi

Molecular functionIon channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-RNO-1296025 ATP sensitive Potassium channels
R-RNO-382556 ABC-family proteins mediated transport
R-RNO-422356 Regulation of insulin secretion
R-RNO-5578775 Ion homeostasis

Protein family/group databases

TCDBi1.A.2.1.7 the inward rectifier k(+) channel (irk-c) family

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-sensitive inward rectifier potassium channel 11
Alternative name(s):
BIR
Inward rectifier K(+) channel Kir6.2
Potassium channel, inwardly rectifying subfamily J member 11
Gene namesi
Name:Kcnj11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi69247 Kcnj11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 68CytoplasmicBy similarityAdd BLAST68
Transmembranei69 – 93Helical; Name=M1By similarityAdd BLAST25
Topological domaini94 – 116ExtracellularBy similarityAdd BLAST23
Intramembranei117 – 128Helical; Pore-forming; Name=H5By similarityAdd BLAST12
Intramembranei129 – 135Pore-formingBy similarity7
Topological domaini136 – 144ExtracellularBy similarity9
Transmembranei145 – 166Helical; Name=M2By similarityAdd BLAST22
Topological domaini167 – 390CytoplasmicBy similarityAdd BLAST224

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3038487
GuidetoPHARMACOLOGYi442

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001549601 – 390ATP-sensitive inward rectifier potassium channel 11Add BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei341Phosphothreonine; by MAPK1By similarity1
Modified residuei385Phosphoserine; by MAPK1By similarity1

Post-translational modificationi

Phosphorylation by MAPK1 results in changes in channel gating that destabilize the closed states and reduce the ATP sensitivity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP70673
PRIDEiP70673

PTM databases

iPTMnetiP70673
PhosphoSitePlusiP70673

Expressioni

Gene expression databases

BgeeiENSRNOG00000021128
GenevisibleiP70673 RN

Interactioni

Subunit structurei

Interacts with ABCC9/SUR2 (By similarity). Interacts with ABCC8/SUR.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Abcc9Q635632EBI-9560239,EBI-8744493

GO - Molecular functioni

  • ankyrin binding Source: BHF-UCL
  • heat shock protein binding Source: RGD
  • ion channel binding Source: Ensembl
  • protein C-terminus binding Source: RGD

Protein-protein interaction databases

ComplexPortaliCPX-181 Inward rectifying potassium channel complex, Kir6.2-SUR2A
CPX-185 Inward rectifying potassium channel complex, Kir6.2-SUR2B
CPX-186 Inward rectifying potassium channel complex, Kir6.2-SUR1
CORUMiP70673
DIPiDIP-58641N
IntActiP70673, 2 interactors
STRINGi10116.ENSRNOP00000028685

Structurei

3D structure databases

ProteinModelPortaliP70673
SMRiP70673
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi130 – 135Selectivity filterBy similarity6

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3827 Eukaryota
ENOG410XQ62 LUCA
GeneTreeiENSGT00760000118842
HOGENOMiHOG000237325
HOVERGENiHBG006178
InParanoidiP70673
KOiK05004
OMAiNGNCNVA
OrthoDBiEOG091G08HC
PhylomeDBiP70673
TreeFamiTF313676

Family and domain databases

Gene3Di2.60.40.1400, 2 hits
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR016449 K_chnl_inward-rec_Kir
IPR003279 K_chnl_inward-rec_Kir6.2
IPR013518 K_chnl_inward-rec_Kir_cyto
PANTHERiPTHR11767 PTHR11767, 1 hit
PTHR11767:SF44 PTHR11767:SF44, 1 hit
PfamiView protein in Pfam
PF01007 IRK, 1 hit
PIRSFiPIRSF005465 GIRK_kir, 1 hit
PRINTSiPR01332 KIR62CHANNEL
PR01320 KIRCHANNEL
SUPFAMiSSF81296 SSF81296, 1 hit

Sequencei

Sequence statusi: Complete.

P70673-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRKGIIPE EYVLTRLAED PTEPRYRTRE RRARFVSKKG NCNVAHKNIR
60 70 80 90 100
EQGRFLQDVF TTLVDLKWPH TLLIFTMSFL CSWLLFAMVW WLIAFAHGDL
110 120 130 140 150
APGEGTNVPC VTSIHSFSSA FLFSIEVQVT IGFGGRMVTE ECPLAILILI
160 170 180 190 200
VQNIVGLMIN AIMLGCIFMK TAQAHRRAET LIFSKHAVIT LRHGRLCFML
210 220 230 240 250
RVGDLRKSMI ISATIHMQVV RKTTSPEGEV VPLHQVDIPM ENGVGGNSIF
260 270 280 290 300
LVAPLIIYHV IDSNSPLYDL APSDLHHHQD LEIIVILEGV VETTGITTQA
310 320 330 340 350
RTSYLADEIL WGQRFVPIVA EEDGRYSVDY SKFGNTVKVP TPLCTARQLD
360 370 380 390
EDRSLLDALT LASSRGPLRK RSVAVAKAKP KFSISPDSLS
Length:390
Mass (Da):43,608
Last modified:February 1, 1997 - v1
Checksum:iC8E59AD298DE4F13
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191L → P in BAA96239 (Ref. 5) Curated1
Sequence conflicti365R → Q in AAB01810 (PubMed:8607800).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86039 mRNA Translation: BAA12971.1
X97041 mRNA Translation: CAA65754.1
U44897 mRNA Translation: AAB01810.1
D61687 mRNA Translation: BAA23630.1
AB043638 mRNA Translation: BAA96239.1
PIRiJC4689
RefSeqiNP_112648.2, NM_031358.3
UniGeneiRn.3985

Genome annotation databases

EnsembliENSRNOT00000028685; ENSRNOP00000028685; ENSRNOG00000021128
GeneIDi83535
KEGGirno:83535
UCSCiRGD:69247 rat

Similar proteinsi

Entry informationi

Entry nameiKCJ11_RAT
AccessioniPrimary (citable) accession number: P70673
Secondary accession number(s): Q62906, Q9JM48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: June 20, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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