UniProtKB - P70673 (KCJ11_RAT)

BLAST

>sp|P70673|KCJ11_RAT ATP-sensitive inward rectifier potassium channel 11 OS=Rattus norvegicus OX=10116 GN=Kcnj11 PE=1 SV=1
MLSRKGIIPEEYVLTRLAEDPTEPRYRTRERRARFVSKKGNCNVAHKNIREQGRFLQDVF
TTLVDLKWPHTLLIFTMSFLCSWLLFAMVWWLIAFAHGDLAPGEGTNVPCVTSIHSFSSA
FLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAET
LIFSKHAVITLRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPM
ENGVGGNSIFLVAPLIIYHVIDSNSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQA
RTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTVKVPTPLCTARQLDEDRSLLDALT
LASSRGPLRKRSVAVAKAKPKFSISPDSLS

Align
Format
Add to basket Added to basket
History
Entry version 148 (12 Sep 2018)
Sequence version 1 (01 Feb 1997)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

ATP-sensitive inward rectifier potassium channel 11

Gene

Kcnj11

Organism

Rattus norvegicus (Rat)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	160	Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity		1

GO - Molecular functionⁱ

ankyrin binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19805355
ATP-activated inward rectifier potassium channel activity
Source: RGD
Inferred from direct assayⁱ
- 17097686
ATP binding Source: Ensembl
heat shock protein binding
Source: RGD
Inferred from physical interactionⁱ
- 20427569
ion channel binding Source: Ensembl
protein C-terminus binding
Source: RGD
Inferred from physical interactionⁱ
- 14672537

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to glucose stimulus
Source: RGD
Inferred from expression patternⁱ
- 19720793
cellular response to nicotine
Source: RGD
Inferred from expression patternⁱ
- 22403787
cellular response to tumor necrosis factor
Source: RGD
Inferred from expression patternⁱ
- 19460779
glucose metabolic process Source: Ensembl
negative regulation of insulin secretion Source: Ensembl
nervous system process Source: Ensembl
positive regulation of cation channel activity
Source: RGD
Inferred from mutant phenotypeⁱ
- 23785408
positive regulation of protein localization to plasma membrane
Source: RGD
Inferred from mutant phenotypeⁱ
- 23695995
potassium ion import Source: GO_Central
potassium ion transport
Source: RGD
Inferred from direct assayⁱ
- 17097686
regulation of membrane potential Source: Ensembl
response to ATP Source: Ensembl
response to drug
Source: RGD
Inferred from expression patternⁱ
- 15964031
response to estradiol
Source: RGD
Inferred from expression patternⁱ
- 23032400
response to ischemia
Source: RGD
Inferred from expression patternⁱ
- 20971764
response to testosterone
Source: RGD
Inferred from expression patternⁱ
- 18950632

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel, Voltage-gated channel
Biological process	Ion transport, Potassium transport, Transport
Ligand	Potassium

Enzyme and pathway databases

Reactomeⁱ	R-RNO-1296025 ATP sensitive Potassium channels R-RNO-382556 ABC-family proteins mediated transport R-RNO-5578775 Ion homeostasis

Reactomeⁱ

R-RNO-1296025 ATP sensitive Potassium channels
R-RNO-382556 ABC-family proteins mediated transport
R-RNO-5578775 Ion homeostasis

Protein family/group databases

TCDBⁱ	1.A.2.1.7 the inward rectifier k(+) channel (irk-c) family

TCDBⁱ

1.A.2.1.7 the inward rectifier k(+) channel (irk-c) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: ATP-sensitive inward rectifier potassium channel 11 Alternative name(s): BIR Inward rectifier K(+) channel Kir6.2 Potassium channel, inwardly rectifying subfamily J member 11
Gene namesⁱ	Name:Kcnj11
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 1

Organism-specific databases

Rat genome database More...RGDⁱ	69247 Kcnj11

RGDⁱ

69247 Kcnj11

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 68	CytoplasmicBy similarityAdd BLAST	68
Transmembraneⁱ	69 – 93	Helical; Name=M1By similarityAdd BLAST	25
Topological domainⁱ	94 – 116	ExtracellularBy similarityAdd BLAST	23
Intramembraneⁱ	117 – 128	Helical; Pore-forming; Name=H5By similarityAdd BLAST	12
Intramembraneⁱ	129 – 135	Pore-formingBy similarity	7
Topological domainⁱ	136 – 144	ExtracellularBy similarity	9
Transmembraneⁱ	145 – 166	Helical; Name=M2By similarityAdd BLAST	22
Topological domainⁱ	167 – 390	CytoplasmicBy similarityAdd BLAST	224

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL3038487
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	442

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000154960	1 – 390	ATP-sensitive inward rectifier potassium channel 11Add BLAST		390

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	341	Phosphothreonine; by MAPK1By similarity		1
Modified residueⁱ	385	Phosphoserine; by MAPK1By similarity		1

Post-translational modificationⁱ

Phosphorylation by MAPK1 results in changes in channel gating that destabilize the closed states and reduce the ATP sensitivity.By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	P70673
PRIDEⁱ	P70673

PTM databases

iPTMnetⁱ	P70673
PhosphoSitePlusⁱ	P70673

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000021128 Expressed in 8 organ(s), highest expression level in skeletal muscle tissue
Genevisibleⁱ	P70673 RN

Interactionⁱ

Subunit structureⁱ

Interacts with ABCC9/SUR2 (By similarity). Interacts with ABCC8/SUR.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Abcc9	Q63563	2	EBI-9560239,EBI-8744493

With

Entry

#Exp.

IntAct

Notes

Abcc9

Q63563

EBI-9560239,EBI-8744493

GO - Molecular functionⁱ

ankyrin binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19805355
heat shock protein binding
Source: RGD
Inferred from physical interactionⁱ
- 20427569
ion channel binding Source: Ensembl
protein C-terminus binding
Source: RGD
Inferred from physical interactionⁱ
- 14672537

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

ComplexPortalⁱ	CPX-181 Inward rectifying potassium channel complex, Kir6.2-SUR2A CPX-185 Inward rectifying potassium channel complex, Kir6.2-SUR2B CPX-186 Inward rectifying potassium channel complex, Kir6.2-SUR1
CORUMⁱ	P70673
Database of interacting proteins More...DIPⁱ	DIP-58641N
IntActⁱ	P70673, 2 interactors
STRINGⁱ	10116.ENSRNOP00000028685

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P70673
SMRⁱ	P70673
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	130 – 135	Selectivity filterBy similarity		6

Sequence similaritiesⁱ

Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3827 Eukaryota ENOG410XQ62 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118842
HOGENOMⁱ	HOG000237325
HOVERGENⁱ	HBG006178
InParanoidⁱ	P70673
KEGG Orthology (KO) More...KOⁱ	K05004
OMAⁱ	NGNCNVA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08HC
PhylomeDBⁱ	P70673
TreeFamⁱ	TF313676

Family and domain databases

Gene3Dⁱ	2.60.40.1400, 2 hits
InterProⁱ	View protein in InterPro IPR014756 Ig_E-set IPR016449 K_chnl_inward-rec_Kir IPR003279 K_chnl_inward-rec_Kir6.2 IPR013518 K_chnl_inward-rec_Kir_cyto
PANTHERⁱ	PTHR11767 PTHR11767, 1 hit PTHR11767:SF44 PTHR11767:SF44, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01007 IRK, 1 hit
PIRSFⁱ	PIRSF005465 GIRK_kir, 1 hit
PRINTSⁱ	PR01332 KIR62CHANNEL PR01320 KIRCHANNEL
SUPFAMⁱ	SSF81296 SSF81296, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P70673-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLSRKGIIPE EYVLTRLAED PTEPRYRTRE RRARFVSKKG NCNVAHKNIR 
        60         70         80         90        100
EQGRFLQDVF TTLVDLKWPH TLLIFTMSFL CSWLLFAMVW WLIAFAHGDL 
       110        120        130        140        150
APGEGTNVPC VTSIHSFSSA FLFSIEVQVT IGFGGRMVTE ECPLAILILI 
       160        170        180        190        200
VQNIVGLMIN AIMLGCIFMK TAQAHRRAET LIFSKHAVIT LRHGRLCFML 
       210        220        230        240        250
RVGDLRKSMI ISATIHMQVV RKTTSPEGEV VPLHQVDIPM ENGVGGNSIF 
       260        270        280        290        300
LVAPLIIYHV IDSNSPLYDL APSDLHHHQD LEIIVILEGV VETTGITTQA 
       310        320        330        340        350
RTSYLADEIL WGQRFVPIVA EEDGRYSVDY SKFGNTVKVP TPLCTARQLD 
       360        370        380        390
EDRSLLDALT LASSRGPLRK RSVAVAKAKP KFSISPDSLS

Length:390

Mass (Da):43,608

Last modified:February 1, 1997 - v1

Checksum:ⁱC8E59AD298DE4F13

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	191	L → P in BAA96239 (Ref. 5) Curated		1
Sequence conflictⁱ	365	R → Q in AAB01810 (PubMed:8607800).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D86039 mRNA Translation: BAA12971.1 X97041 mRNA Translation: CAA65754.1 U44897 mRNA Translation: AAB01810.1 D61687 mRNA Translation: BAA23630.1 AB043638 mRNA Translation: BAA96239.1
PIRⁱ	JC4689
NCBI Reference Sequences More...RefSeqⁱ	NP_112648.2, NM_031358.3
UniGeneⁱ	Rn.3985

Genome annotation databases

Ensemblⁱ	ENSRNOT00000028685; ENSRNOP00000028685; ENSRNOG00000021128
GeneIDⁱ	83535
KEGGⁱ	rno:83535
UCSC genome browser More...UCSCⁱ	RGD:69247 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P70673	ATP-sensitive inward rectifier potassium channel 11	)	HUMAN		390	UniRef90_Q14654
ATP-sensitive inward rectifier potassium channel 11		RABIT		390
ATP-sensitive inward rectifier potassium channel 11		CAVPO		390
KCNJ11 isoform 4 (Fragment)		PONAB		153
ATP-sensitive inward rectifier potassium channel 11		PTEAL		395
+146

Protein	Similar proteins		Species	Score	Length	Source
P70673	ATP-sensitive inward rectifier potassium channel 11	)	HUMAN		390	UniRef50_Q14654
ATP-sensitive inward rectifier potassium channel 11		RABIT		390
ATP-sensitive inward rectifier potassium channel 11		CAVPO		390
KCNJ11 isoform 4 (Fragment)		PONAB		153
ATP-sensitive inward rectifier potassium channel 11		MYODS		395
+434

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D86039 mRNA Translation: BAA12971.1 X97041 mRNA Translation: CAA65754.1 U44897 mRNA Translation: AAB01810.1 D61687 mRNA Translation: BAA23630.1 AB043638 mRNA Translation: BAA96239.1
PIRⁱ	JC4689
RefSeqⁱ	NP_112648.2, NM_031358.3
UniGeneⁱ	Rn.3985

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5TWV	electron microscopy	6.30	A/C/E/G	1-390	[»]
	6BAA	electron microscopy	3.63	A/B/C/D	1-390	[»]
ProteinModelPortalⁱ	P70673
SMRⁱ	P70673
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

ComplexPortalⁱ	CPX-181 Inward rectifying potassium channel complex, Kir6.2-SUR2A CPX-185 Inward rectifying potassium channel complex, Kir6.2-SUR2B CPX-186 Inward rectifying potassium channel complex, Kir6.2-SUR1
CORUMⁱ	P70673
DIPⁱ	DIP-58641N
IntActⁱ	P70673, 2 interactors
STRINGⁱ	10116.ENSRNOP00000028685

Chemistry databases

ChEMBLⁱ	CHEMBL3038487
GuidetoPHARMACOLOGYⁱ	442

Protein family/group databases

TCDBⁱ	1.A.2.1.7 the inward rectifier k(+) channel (irk-c) family

TCDBⁱ

1.A.2.1.7 the inward rectifier k(+) channel (irk-c) family

PTM databases

iPTMnetⁱ	P70673
PhosphoSitePlusⁱ	P70673

Proteomic databases

PaxDbⁱ	P70673
PRIDEⁱ	P70673

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000028685; ENSRNOP00000028685; ENSRNOG00000021128
GeneIDⁱ	83535
KEGGⁱ	rno:83535
UCSCⁱ	RGD:69247 rat

Organism-specific databases

CTDⁱ	3767
RGDⁱ	69247 Kcnj11

Phylogenomic databases

eggNOGⁱ	KOG3827 Eukaryota ENOG410XQ62 LUCA
GeneTreeⁱ	ENSGT00760000118842
HOGENOMⁱ	HOG000237325
HOVERGENⁱ	HBG006178
InParanoidⁱ	P70673
KOⁱ	K05004
OMAⁱ	NGNCNVA
OrthoDBⁱ	EOG091G08HC
PhylomeDBⁱ	P70673
TreeFamⁱ	TF313676

Enzyme and pathway databases

Reactomeⁱ	R-RNO-1296025 ATP sensitive Potassium channels R-RNO-382556 ABC-family proteins mediated transport R-RNO-5578775 Ion homeostasis

Reactomeⁱ

R-RNO-1296025 ATP sensitive Potassium channels
R-RNO-382556 ABC-family proteins mediated transport
R-RNO-5578775 Ion homeostasis

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P70673

PROⁱ

PR:P70673

Gene expression databases

Bgeeⁱ	ENSRNOG00000021128 Expressed in 8 organ(s), highest expression level in skeletal muscle tissue
Genevisibleⁱ	P70673 RN

Family and domain databases

Gene3Dⁱ	2.60.40.1400, 2 hits
InterProⁱ	View protein in InterPro IPR014756 Ig_E-set IPR016449 K_chnl_inward-rec_Kir IPR003279 K_chnl_inward-rec_Kir6.2 IPR013518 K_chnl_inward-rec_Kir_cyto
PANTHERⁱ	PTHR11767 PTHR11767, 1 hit PTHR11767:SF44 PTHR11767:SF44, 1 hit
Pfamⁱ	View protein in Pfam PF01007 IRK, 1 hit
PIRSFⁱ	PIRSF005465 GIRK_kir, 1 hit
PRINTSⁱ	PR01332 KIR62CHANNEL PR01320 KIRCHANNEL
SUPFAMⁱ	SSF81296 SSF81296, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KCJ11_RAT
Accessionⁱ	P70673Primary (citable) accession number: P70673 Secondary accession number(s): Q62906, Q9JM48
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	February 1, 1997
	Last modified:	September 12, 2018
	This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P70673 (KCJ11_RAT)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

ATP-sensitive inward rectifier potassium channel 11

Kcnj11

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Endoplasmic reticulum

Endosome

Mitochondrion

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ