ATP-sensitive inward rectifier potassium channel 11

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ankyrin binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Dual role of K ATP channel C-terminal motif in membrane targeting and metabolic regulation."
    Kline C.F., Kurata H.T., Hund T.J., Cunha S.R., Koval O.M., Wright P.J., Christensen M., Anderson M.E., Nichols C.G., Mohler P.J.
    Proc Natl Acad Sci U S A 106:16669-16674(2009) [PubMed] [Europe PMC] [Abstract]
• ATP-activated inward rectifier potassium channel activity Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Identification of two types of ATP-sensitive K+ channels in rat ventricular myocytes."
    Wu S.N., Wu A.Z., Sung R.J.
    Life Sci 80:378-387(2007) [PubMed] [Europe PMC] [Abstract]
• ATPase-coupled cation transmembrane transporter activity Source: ARUK-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Conserved functional consequences of disease-associated mutations in the slide-helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel."
    Cooper P.E., McClenaghan C., Chen X., Stary-Weinzinger A., Nichols C.G.
    J. Biol. Chem. 292:17387-17398(2017) [PubMed] [Europe PMC] [Abstract]
• ATP binding Source: RGD
• heat shock protein binding Source: RGDInferred from physical interactionⁱ
  • "Role of Hsp90 in biogenesis of the beta-cell ATP-sensitive potassium channel complex."
    Yan F.F., Pratt E.B., Chen P.C., Wang F., Skach W.R., David L.L., Shyng S.L.
    Mol Biol Cell 21:1945-1954(2010) [PubMed] [Europe PMC] [Abstract]
• inward rectifier potassium channel activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• ion channel binding Source: RGD
• protein C-terminus binding Source: RGDInferred from physical interactionⁱ
  • "Proximal C-terminal domain of sulphonylurea receptor 2A interacts with pore-forming Kir6 subunits in KATP channels."
    Rainbow R.D., James M., Hudman D., Al Johi M., Singh H., Watson P.J., Ashmole I., Davies N.W., Lodwick D., Norman R.I.
    Biochem J 379:173-181(2004) [PubMed] [Europe PMC] [Abstract]
• voltage-gated potassium channel activity Source: RGD

GO - Biological processⁱ

• cellular response to glucose stimulus Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Glucose deprivation regulates KATP channel trafficking via AMP-activated protein kinase in pancreatic beta-cells."
    Lim A., Park S.H., Sohn J.W., Jeon J.H., Park J.H., Song D.K., Lee S.H., Ho W.K.
    Diabetes 58:2813-2819(2009) [PubMed] [Europe PMC] [Abstract]
• cellular response to nicotine Source: RGDInferred from expression patternⁱ
  • "Chronic nicotine induces hypoxia inducible factor-2alpha in perinatal rat adrenal chromaffin cells: role in transcriptional upregulation of KATP channel subunit Kir6.2."
    Salman S., Brown S.T., Nurse C.A.
    Am J Physiol Cell Physiol 302:C1531-8(2012) [PubMed] [Europe PMC] [Abstract]
• cellular response to tumor necrosis factor Source: RGDInferred from expression patternⁱ
  • "Angiotensin II and tumour necrosis factor alpha as mediators of ATP-dependent potassium channel remodelling in post-infarction heart failure."
    Isidoro Tavares N., Philip-Couderc P., Baertschi A.J., Lerch R., Montessuit C.
    Cardiovasc Res 83:726-736(2009) [PubMed] [Europe PMC] [Abstract]
• glucose metabolic process Source: RGD
• inorganic cation transmembrane transport Source: ARUK-UCLInferred from genetic interactionⁱ
  • "Conserved functional consequences of disease-associated mutations in the slide-helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel."
    Cooper P.E., McClenaghan C., Chen X., Stary-Weinzinger A., Nichols C.G.
    J. Biol. Chem. 292:17387-17398(2017) [PubMed] [Europe PMC] [Abstract]
• negative regulation of insulin secretion Source: RGD
• nervous system process Source: RGD
• positive regulation of cation channel activity Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Pregabalin attenuates excitotoxicity in diabetes."
    Huang C.W., Lai M.C., Cheng J.T., Tsai J.J., Huang C.C., Wu S.N.
    PLoS One 8:e65154-e65154(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein localization to plasma membrane Source: RGDInferred from mutant phenotypeⁱ
  • "Engineered Kir6.2 mutations that correct the trafficking defect of K(ATP) channels caused by specific SUR1 mutations."
    Zhou Q., Pratt E.B., Shyng S.L.
    Channels (Austin) 7:313-317(2013) [PubMed] [Europe PMC] [Abstract]
• potassium ion import across plasma membrane Source: RGD
• potassium ion transmembrane transport Source: RGD
• potassium ion transport Source: RGDInferred from direct assayⁱ
  • "Identification of two types of ATP-sensitive K+ channels in rat ventricular myocytes."
    Wu S.N., Wu A.Z., Sung R.J.
    Life Sci 80:378-387(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of insulin secretion Source: RGD
• regulation of ion transmembrane transport Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of membrane potential Source: RGD
• response to ATP Source: ARUK-UCLInferred from genetic interactionⁱ
  • "Conserved functional consequences of disease-associated mutations in the slide-helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel."
    Cooper P.E., McClenaghan C., Chen X., Stary-Weinzinger A., Nichols C.G.
    J. Biol. Chem. 292:17387-17398(2017) [PubMed] [Europe PMC] [Abstract]
• response to drug Source: RGDInferred from expression patternⁱ
  • "Iptakalim, opener of K(ATP), reverses the enhanced expression of genes encoding K(ATP) subunits in spontaneously hypertensive rats."
    Gao M., Xue H., Wang Y., Wang H.
    Life Sci 77:2743-2751(2005) [PubMed] [Europe PMC] [Abstract]
• response to estradiol Source: RGDInferred from expression patternⁱ
  • "Neuroprotective effects of 17beta-estradiol associate with KATP in rat brain."
    Zhang D., Xia H., Xu L., Zhang C., Yao W., Wang Y., Ren J., Wu J., Tian Y., Liu W., Wang X.
    Neuroreport 23:952-957(2012) [PubMed] [Europe PMC] [Abstract]
• response to ischemia Source: RGDInferred from expression patternⁱ
  • "Endosomal KATP channels as a reservoir after myocardial ischemia: a role for SUR2 subunits."
    Bao L., Hadjiolova K., Coetzee W.A., Rindler M.J.
    Am J Physiol Heart Circ Physiol 300:H262-70(2011) [PubMed] [Europe PMC] [Abstract]
• response to testosterone Source: RGDInferred from expression patternⁱ
  • "A role for ATP-sensitive potassium channels in male sexual behavior."
    McDevitt M.A., Thorsness R.J., Levine J.E.
    Horm Behav 55:366-374(2009) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• ankyrin binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Dual role of K ATP channel C-terminal motif in membrane targeting and metabolic regulation."
    Kline C.F., Kurata H.T., Hund T.J., Cunha S.R., Koval O.M., Wright P.J., Christensen M., Anderson M.E., Nichols C.G., Mohler P.J.
    Proc Natl Acad Sci U S A 106:16669-16674(2009) [PubMed] [Europe PMC] [Abstract]
• heat shock protein binding Source: RGDInferred from physical interactionⁱ
  • "Role of Hsp90 in biogenesis of the beta-cell ATP-sensitive potassium channel complex."
    Yan F.F., Pratt E.B., Chen P.C., Wang F., Skach W.R., David L.L., Shyng S.L.
    Mol Biol Cell 21:1945-1954(2010) [PubMed] [Europe PMC] [Abstract]
• ion channel binding Source: RGD
• protein C-terminus binding Source: RGDInferred from physical interactionⁱ
  • "Proximal C-terminal domain of sulphonylurea receptor 2A interacts with pore-forming Kir6 subunits in KATP channels."
    Rainbow R.D., James M., Hudman D., Al Johi M., Singh H., Watson P.J., Ashmole I., Davies N.W., Lodwick D., Norman R.I.
    Biochem J 379:173-181(2004) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Motif

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MLSRKGIIPE EYVLTRLAED PTEPRYRTRE RRARFVSKKG NCNVAHKNIR 
        60         70         80         90        100
EQGRFLQDVF TTLVDLKWPH TLLIFTMSFL CSWLLFAMVW WLIAFAHGDL 
       110        120        130        140        150
APGEGTNVPC VTSIHSFSSA FLFSIEVQVT IGFGGRMVTE ECPLAILILI 
       160        170        180        190        200
VQNIVGLMIN AIMLGCIFMK TAQAHRRAET LIFSKHAVIT LRHGRLCFML 
       210        220        230        240        250
RVGDLRKSMI ISATIHMQVV RKTTSPEGEV VPLHQVDIPM ENGVGGNSIF 
       260        270        280        290        300
LVAPLIIYHV IDSNSPLYDL APSDLHHHQD LEIIVILEGV VETTGITTQA 
       310        320        330        340        350
RTSYLADEIL WGQRFVPIVA EEDGRYSVDY SKFGNTVKVP TPLCTARQLD 
       360        370        380        390
EDRSLLDALT LASSRGPLRK RSVAVAKAKP KFSISPDSLS            

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. SIMILARITY comments
   Index of protein domains and families