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Entry version 148 (16 Oct 2019)
Sequence version 2 (27 Jul 2011)
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Protein

Nascent polypeptide-associated complex subunit alpha, muscle-specific form

Gene

Naca

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • myoblast migration Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nascent polypeptide-associated complex subunit alpha, muscle-specific form
Alternative name(s):
Alpha-NAC, muscle-specific form
Short name:
skNAC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Naca
Synonyms:Gm1878
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:106095 Naca

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Partial embryonic lethality by embryonic day 12.5, with ventricular hypoplasia and decreased cardiomyocyte proliferation. Viable skNAC(-/-) adult mice have reduced postnatal skeletal muscle growth and impaired regenerative capacity after cardiotoxin-induced injury. Satellite cells have impaired survival compared with wild-type.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1952L → A: Loss of interaction with SMYD1. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001355781 – 2187Nascent polypeptide-associated complex subunit alpha, muscle-specific formAdd BLAST2187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei247Asymmetric dimethylarginineCombined sources1
Modified residuei590PhosphothreonineCombined sources1
Modified residuei822PhosphoserineCombined sources1
Modified residuei1174PhosphoserineCombined sources1
Modified residuei1177PhosphoserineCombined sources1
Modified residuei1364PhosphothreonineCombined sources1
Modified residuei1368PhosphoserineCombined sources1
Modified residuei1392PhosphoserineCombined sources1
Modified residuei1398PhosphothreonineCombined sources1
Modified residuei1400PhosphoserineCombined sources1
Modified residuei1423PhosphoserineCombined sources1
Modified residuei1492PhosphoserineCombined sources1
Modified residuei2015Phosphoserine; by ILK1Curated1
Modified residuei2104PhosphoserineBy similarity1
Modified residuei2114N6-acetyllysine; alternateCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki2114Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei2131Phosphothreonine; by GSK3-betaCombined sourcesCurated1
Modified residuei2133PhosphothreonineBy similarity1
Modified residuei2138PhosphoserineCombined sources1
Modified residuei2158PhosphoserineBy similarity1
Modified residuei2163PhosphoserineBy similarity1
Modified residuei2175PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation of Ser-2015 by ILK during cell adhesion may promote nuclear localization. Phosphorylation of Thr-2131 by GSK3B may promote proteasome mediated degradation.

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P70670

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P70670

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P70670

PeptideAtlas

More...
PeptideAtlasi
P70670

PRoteomics IDEntifications database

More...
PRIDEi
P70670

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P70670

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P70670

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P70670

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed in heart and skeletal muscle: it is present in differentiated myotubes but not in myoblasts.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed concomitant with the onset of mineralization in ossification centers of developing bone.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced in muscle by wounding.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000061315 Expressed in 42 organ(s), highest expression level in thymus

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P70670 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P70670 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via PXLXP motif) with the muscle-restricted histone methyltransferase SMYD1 (via MYND-type zinc finger).

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
201682, 9 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P70670

Protein interaction database and analysis system

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IntActi
P70670, 7 interactors

Molecular INTeraction database

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MINTi
P70670

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000089680

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P70670

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2042 – 2107NAC-A/BPROSITE-ProRule annotationAdd BLAST66
Domaini2148 – 2185UBAAdd BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2041 – 2052Required for DNA-bindingAdd BLAST12

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1950 – 1954PXLXP5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NAC-alpha family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2239 Eukaryota
COG1308 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00440000033468

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000168224

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P70670

KEGG Orthology (KO)

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KOi
K03626

Identification of Orthologs from Complete Genome Data

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OMAi
KESQATP

Database of Orthologous Groups

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OrthoDBi
1331328at2759

TreeFam database of animal gene trees

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TreeFami
TF313348

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.20.70.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016641 EGD2/NACA
IPR038187 NAC_A/B_dom_sf
IPR002715 Nas_poly-pep-assoc_cplx_dom

The PANTHER Classification System

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PANTHERi
PTHR21713 PTHR21713, 4 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01849 NAC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01407 NAC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51151 NAC_AB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 2 (identifier: P70670-1) [UniParc]FASTAAdd to basket
Also known as: Gp220, skNAC

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPGEATETVP ATEQELPQPQ AETAVLPMSS ALKVAAVGQP GPTPPSSLGP
60 70 80 90 100
QQSPIVTAHQ PSPLPSSVSS TPFEVPFAQP ITAETALPSG TAPPTPTFLP
110 120 130 140 150
HLIGPPISPA ALALASPMIG LAQKGARSSS APLSLVALAP HSVQKSSVCP
160 170 180 190 200
PHPLTSPPSA AGAELGALTA SIPPLEPKTS TSQVPSQGTL NLKGTAPCPP
210 220 230 240 250
DVVRAFPSHL ENPLASVQPG LMSCPQTLSN TSPVKGVPIS SALTQSRLSL
260 270 280 290 300
NLKGPVSPPA RNTAAPSIPL APSTSLGCHL PLLHHSSVDS PIQPPGQSGL
310 320 330 340 350
AVSNPTSVGH SGIAASCPPE RCVVPALPSR LLAVDSGAAP SDDKGSSAVT
360 370 380 390 400
NELCSPPGSS NVAGTSLSPK ASLVPKGSNV ALQPLVTQVP ASQKTGLKEI
410 420 430 440 450
PVSCIGATHH ALDNPSAISV APATHVPPPT SSGLVSSKDP ASPVTSLVVP
460 470 480 490 500
AAHKQFPAPP ASATLGVPVS PLPATEGLKN LPISALVNVG APVSPAQAGL
510 520 530 540 550
PTRKDTTLQP LAPIALKESP SSQSASSLEV LSEDTVTKKT TGGPAPVVRP
560 570 580 590 600
AIAGVATTTS LRADSPPAVI RADSCVSPNT VSQPLKRSVT DPAMAPRTAK
610 620 630 640 650
NTAPSTTSPL VPLASEGCPV ASSMALSPQN ASVSETALAL SPEIPKSVPF
660 670 680 690 700
PDPPLAEISF SNARKVDAVS HMESSGSSRQ GHPDASVTAK GTVVCLADSS
710 720 730 740 750
LDTSVSASKG SALSGASSPL YPLEVSFLPE AGLAVQGPKG SLNKLSPTPP
760 770 780 790 800
SSKGAPVPST GAPPSPKGAP IVPTESSISS KQVPAEILPS PQKTPEVTAS
810 820 830 840 850
RLISAVQSPK VDPIMSDVTP TSPKKTSATA VPKDTSATLS LKSVPAVTSL
860 870 880 890 900
SPPKAPVAPS NEATIVPTEI PTSLKNALAA ATPKETLATS IPKVTSPSPQ
910 920 930 940 950
KTPKSVSLKG APAMTSKKAT EIAASKDVSP SQFPKEVPLL PHVPPTSPPK
960 970 980 990 1000
SPVSDTLSGA LTSPPPKGPP ATLAETPTYP KKSPKPAASK KTPATPSPEG
1010 1020 1030 1040 1050
VTAVPLEIPP CSKKAPKTAA PKESSATSSS KRAPKTAVSK EIPSKGVTAV
1060 1070 1080 1090 1100
PLEISLPLKE TSKSATPGEK SASSPKRSPK TAGPKETPPG GVTAVPPEIS
1110 1120 1130 1140 1150
LPPKETPQNA TPNESLAASS QKRSPKTSVP KETPPGGVTA MPLEIPSAPQ
1160 1170 1180 1190 1200
KAPKTAVPKQ IPTPEDAVTI LAGSPLSPKK ASKTAAPKEA PATPSVGVIA
1210 1220 1230 1240 1250
VSGEISPSPK KTSKTAAPKE NSATLPPKRS PKTAAPKETP ATSSEGVTAV
1260 1270 1280 1290 1300
PSEISPSPPT PASKGVPVTL TPKGAPNALA ESPASPKKVP KTAAPEETST
1310 1320 1330 1340 1350
TPSPQKIPKV AGPKEASATP PSKKTPKTAV PKETSAPSEG VTAVPLEIPP
1360 1370 1380 1390 1400
SPRKAPKTAA PKETPAPSPE GATTAPVQIP PSPRKGSKKA GSKETPTTPS
1410 1420 1430 1440 1450
PEGVTAAPLE IPISSKKTSK MASPKETLVT PSSKKLSQTV GPKETSLEGA
1460 1470 1480 1490 1500
TAVPLEIPPS HKKAPKTVDP KQVPLTPSPK DAPTTLAESP SSPKKAPKTA
1510 1520 1530 1540 1550
APPSERVTTV PPEKPATPQK ASATTASKVP VPAETQEVAV SSRETPVTPA
1560 1570 1580 1590 1600
VPPVKNPSSH KKTSKTIELK EAPATLPPSP TKSPKIPSSK KAPRTSAPKE
1610 1620 1630 1640 1650
FPASPSIKPV TTSLAQTAPP SLQKAPSTTI PKENLAAPAV LPVSSKSPAA
1660 1670 1680 1690 1700
PAAASASLSP ATAAPQTAPK EATTIPSCKK AAATETPIET STAPSLEGAP
1710 1720 1730 1740 1750
KETSETSVSK VLMSSPPKKA SSSKRASTLP ATTLPSLKEA SVLSPTATSS
1760 1770 1780 1790 1800
GKDSHISPVS DACSTGTTTP QASEKLPSKK GPTAFTEMLA APAPESALAI
1810 1820 1830 1840 1850
TAPIQKSPGA NSNSASSPKC PDPSSKKDTK GLPSAVALAP QTVPVEKDTS
1860 1870 1880 1890 1900
KAIETLLVSP AKGSDCLHSP KGPVGSQVAT PLAAFTSDKV PPEAVSASVA
1910 1920 1930 1940 1950
PKPAPAASLT LAPSPVAPLP PKQPLLESAP GSVLESPSKL PVPAEEDELP
1960 1970 1980 1990 2000
PLIPPEAVSG GEPFQPILVN MPAPKPAGTP APAPSAKQPV LKNNKGSGTE
2010 2020 2030 2040 2050
SDSDESVPEL EEQDSTQTAT QQAQLAAAAE IDEEPVSKAK QSRSEKKARK
2060 2070 2080 2090 2100
AMSKLGLRQV TGVTRVTIRK SKNILFVITK PDVYKSPASD TYIVFGEAKI
2110 2120 2130 2140 2150
EDLSQQAQLA AAEKFKVQGE AVSNIQENTQ TPTVQEESEE EEVDETGVEV
2160 2170 2180
KDIELVMSQA NVSRAKAVRA LKNNSNDIVN AIMELTM
Length:2,187
Mass (Da):220,499
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7BB6EDE3538F0954
GO
Isoform 1 (identifier: Q60817-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q60817.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:215
Mass (Da):23,384
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti941P → Q in AAB18734 (PubMed:8698236).Curated1
Sequence conflicti941P → Q in AAB18732 (PubMed:8698236).Curated1
Sequence conflicti1523A → G in AAB18734 (PubMed:8698236).Curated1
Sequence conflicti1523A → G in AAB18732 (PubMed:8698236).Curated1
Sequence conflicti1653A → R in AAB18734 (PubMed:8698236).Curated1
Sequence conflicti1653A → R in AAB18732 (PubMed:8698236).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U48364 mRNA Translation: AAB18734.1
U48363 Genomic DNA Translation: AAB18732.1
AC131120 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS48723.1 [P70670-1]

Protein sequence database of the Protein Information Resource

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PIRi
T30826

NCBI Reference Sequences

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RefSeqi
NP_001106670.1, NM_001113199.1 [P70670-1]
NP_038636.2, NM_013608.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000092048; ENSMUSP00000089680; ENSMUSG00000061315 [P70670-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
17938

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:17938

UCSC genome browser

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UCSCi
uc007hlc.2 mouse [P70670-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48364 mRNA Translation: AAB18734.1
U48363 Genomic DNA Translation: AAB18732.1
AC131120 Genomic DNA No translation available.
CCDSiCCDS48723.1 [P70670-1]
PIRiT30826
RefSeqiNP_001106670.1, NM_001113199.1 [P70670-1]
NP_038636.2, NM_013608.3

3D structure databases

SMRiP70670
ModBaseiSearch...

Protein-protein interaction databases

BioGridi201682, 9 interactors
ELMiP70670
IntActiP70670, 7 interactors
MINTiP70670
STRINGi10090.ENSMUSP00000089680

PTM databases

iPTMnetiP70670
PhosphoSitePlusiP70670
SwissPalmiP70670

Proteomic databases

EPDiP70670
jPOSTiP70670
PaxDbiP70670
PeptideAtlasiP70670
PRIDEiP70670

Genome annotation databases

EnsembliENSMUST00000092048; ENSMUSP00000089680; ENSMUSG00000061315 [P70670-1]
GeneIDi17938
KEGGimmu:17938
UCSCiuc007hlc.2 mouse [P70670-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4666
MGIiMGI:106095 Naca

Phylogenomic databases

eggNOGiKOG2239 Eukaryota
COG1308 LUCA
GeneTreeiENSGT00440000033468
HOGENOMiHOG000168224
InParanoidiP70670
KOiK03626
OMAiKESQATP
OrthoDBi1331328at2759
TreeFamiTF313348

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Naca mouse

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000061315 Expressed in 42 organ(s), highest expression level in thymus
ExpressionAtlasiP70670 baseline and differential
GenevisibleiP70670 MM

Family and domain databases

Gene3Di2.20.70.30, 1 hit
InterProiView protein in InterPro
IPR016641 EGD2/NACA
IPR038187 NAC_A/B_dom_sf
IPR002715 Nas_poly-pep-assoc_cplx_dom
PANTHERiPTHR21713 PTHR21713, 4 hits
PfamiView protein in Pfam
PF01849 NAC, 1 hit
SMARTiView protein in SMART
SM01407 NAC, 1 hit
PROSITEiView protein in PROSITE
PS51151 NAC_AB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNACAM_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P70670
Secondary accession number(s): E9QMB1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 27, 2011
Last modified: October 16, 2019
This is version 148 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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