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Protein

SPARC-like protein 1

Gene

Sparcl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi621 – 632PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: GO_Central
  • collagen binding Source: GO_Central
  • extracellular matrix binding Source: GO_Central

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
SPARC-like protein 1
Alternative name(s):
Extracellular matrix protein 2
Matrix glycoprotein Sc1
Gene namesi
Name:Sparcl1
Synonyms:Ecm2, Sc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:108110 Sparcl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000002031317 – 650SPARC-like protein 1Add BLAST634

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei70PhosphoserineBy similarity1
Modified residuei78PhosphoserineBy similarity1
Modified residuei86PhosphoserineBy similarity1
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei155PhosphoserineBy similarity1
Modified residuei163PhosphoserineBy similarity1
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei272PhosphoserineBy similarity1
Modified residuei353PhosphoserineCombined sources1
Modified residuei406PhosphoserineCombined sources1
Disulfide bondi419 ↔ 430PROSITE-ProRule annotation
Disulfide bondi424 ↔ 440PROSITE-ProRule annotation
Disulfide bondi442 ↔ 476PROSITE-ProRule annotation
Disulfide bondi448 ↔ 469PROSITE-ProRule annotation
Disulfide bondi458 ↔ 495PROSITE-ProRule annotation
Glycosylationi462N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi501 ↔ 612PROSITE-ProRule annotation
Disulfide bondi620 ↔ 636PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP70663
PaxDbiP70663
PeptideAtlasiP70663
PRIDEiP70663

PTM databases

iPTMnetiP70663
PhosphoSitePlusiP70663

Expressioni

Tissue specificityi

Highest expression in brain. Moderate levels in heart, adrenal gland, epididymis and lung. Low levels in kidney, eye, liver, spleen, submandibular gland and testis.

Gene expression databases

BgeeiENSMUSG00000029309 Expressed in 278 organ(s), highest expression level in superior colliculus
CleanExiMM_SPARCL1
ExpressionAtlasiP70663 baseline and differential
GenevisibleiP70663 MM

Interactioni

Protein-protein interaction databases

BioGridi199367, 1 interactor
IntActiP70663, 2 interactors
MINTiP70663
STRINGi10090.ENSMUSP00000031249

Structurei

3D structure databases

ProteinModelPortaliP70663
SMRiP70663
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini418 – 440Follistatin-likeAdd BLAST23
Domaini436 – 497Kazal-likePROSITE-ProRule annotationAdd BLAST62
Domaini608 – 643EF-handPROSITE-ProRule annotationAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi192 – 277Glu-richAdd BLAST86
Compositional biasi192 – 209Poly-GluAdd BLAST18

Sequence similaritiesi

Belongs to the SPARC family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4004 Eukaryota
ENOG41101WW LUCA
GeneTreeiENSGT00510000046787
HOGENOMiHOG000063702
HOVERGENiHBG079212
InParanoidiP70663
OMAiQLYEPNP
OrthoDBiEOG091G0CPG
TreeFamiTF319356

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR003645 Fol_N
IPR015369 Follistatin/Osteonectin_EGF
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR001999 Osteonectin_CS
IPR037641 SPARC
IPR016359 SPARC-like_p1
IPR019577 SPARC/Testican_Ca-bd-dom
PANTHERiPTHR13866 PTHR13866, 1 hit
PfamiView protein in Pfam
PF09289 FOLN, 1 hit
PF00050 Kazal_1, 1 hit
PF10591 SPARC_Ca_bdg, 1 hit
PIRSFiPIRSF002574 SPARC-like_p1, 1 hit
SMARTiView protein in SMART
SM00274 FOLN, 1 hit
SM00280 KAZAL, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS51465 KAZAL_2, 1 hit
PS00612 OSTEONECTIN_1, 1 hit
PS00613 OSTEONECTIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P70663-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKAVLLLLCA LGTAVAIPTS TRFLSDHSNP TTATLVTPED ATVPIAGVEA
60 70 80 90 100
TADIENHPSD KAEKPSALNS EEETHEQSTE QDKTYSFEVD LKDEEDGDGD
110 120 130 140 150
LSVDPTEGTL TLDLQEGTSE PQQKSLPENG DFPATVSTSY VDPNQRANIT
160 170 180 190 200
KGKESQEQPV SDSHQQPNES SKQTQDLKAE ESQTQDPDIP NEEEEEEEDE
210 220 230 240 250
EEEEEEEPED IGAPSDNQEE GKEPLEEQPT SKWEGNREQS DDTLEESSQP
260 270 280 290 300
TQISKTEKHQ SEQGNQGQES DSEAEGEDKA AGSKEHIPHT EQQDQEGKAG
310 320 330 340 350
LEAIGNQKDT DEKAVSTEPT DAAVVPRSHG GAGDNGGGDD SKHGAGDDYF
360 370 380 390 400
IPSQEFLEAE RMHSLSYYLK YGGGEETTTG ESENRREAAD NQEAKKAESS
410 420 430 440 450
PNAEPSDEGN SREHSAGSCT NFQCKRGHIC KTDPQGKPHC VCQDPETCPP
460 470 480 490 500
AKILDQACGT DNQTYASSCH LFATKCRLEG TKKGHQLQLD YFGACKSIPA
510 520 530 540 550
CTDFEVAQFP LRMRDWLKNI LMQLYEPNPK HGGYLNEKQR SKVKKIYLDE
560 570 580 590 600
KRLLAGDHPI ELLLRDFKKN YHMYVYPVHW QFNELDQHPA DRILTHSELA
610 620 630 640 650
PLRASLVPME HCITRFFEEC DPNKDKHITL KEWGHCFGIK EEDIDENLLF
Length:650
Mass (Da):72,287
Last modified:July 27, 2011 - v3
Checksum:i8E2CA0145DE3E66E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JFH7A0A0G2JFH7_MOUSE
SPARC-like protein 1
Sparcl1
239Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25S → F in AAC53172 (PubMed:9199668).Curated1
Sequence conflicti59S → N in AAB06444 (PubMed:8938431).Curated1
Sequence conflicti59S → N in AAB08451 (PubMed:8938431).Curated1
Sequence conflicti59S → N in AAC53172 (PubMed:9199668).Curated1
Sequence conflicti59S → N in AAH03759 (PubMed:15489334).Curated1
Sequence conflicti199D → E in AAB06444 (PubMed:8938431).Curated1
Sequence conflicti199D → E in AAB08451 (PubMed:8938431).Curated1
Sequence conflicti281A → S in AAB06444 (PubMed:8938431).Curated1
Sequence conflicti281A → S in AAB08451 (PubMed:8938431).Curated1
Sequence conflicti385R → Q in AAB06444 (PubMed:8938431).Curated1
Sequence conflicti385R → Q in AAB08451 (PubMed:8938431).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66166
, U66158, U66159, U66160, U66161, U66162, U66163, U66164, U66165 Genomic DNA Translation: AAB06444.1
U77330 mRNA Translation: AAC53172.1
U64827 mRNA Translation: AAB08451.1
AL714024 Genomic DNA No translation available.
BC003759 mRNA Translation: AAH03759.1
CCDSiCCDS19483.1
RefSeqiNP_034227.3, NM_010097.4
XP_006534831.1, XM_006534768.1
XP_017176145.1, XM_017320656.1
UniGeneiMm.29027

Genome annotation databases

EnsembliENSMUST00000031249; ENSMUSP00000031249; ENSMUSG00000029309
GeneIDi13602
KEGGimmu:13602
UCSCiuc008ykb.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66166
, U66158, U66159, U66160, U66161, U66162, U66163, U66164, U66165 Genomic DNA Translation: AAB06444.1
U77330 mRNA Translation: AAC53172.1
U64827 mRNA Translation: AAB08451.1
AL714024 Genomic DNA No translation available.
BC003759 mRNA Translation: AAH03759.1
CCDSiCCDS19483.1
RefSeqiNP_034227.3, NM_010097.4
XP_006534831.1, XM_006534768.1
XP_017176145.1, XM_017320656.1
UniGeneiMm.29027

3D structure databases

ProteinModelPortaliP70663
SMRiP70663
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199367, 1 interactor
IntActiP70663, 2 interactors
MINTiP70663
STRINGi10090.ENSMUSP00000031249

PTM databases

iPTMnetiP70663
PhosphoSitePlusiP70663

Proteomic databases

MaxQBiP70663
PaxDbiP70663
PeptideAtlasiP70663
PRIDEiP70663

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031249; ENSMUSP00000031249; ENSMUSG00000029309
GeneIDi13602
KEGGimmu:13602
UCSCiuc008ykb.2 mouse

Organism-specific databases

CTDi8404
MGIiMGI:108110 Sparcl1

Phylogenomic databases

eggNOGiKOG4004 Eukaryota
ENOG41101WW LUCA
GeneTreeiENSGT00510000046787
HOGENOMiHOG000063702
HOVERGENiHBG079212
InParanoidiP70663
OMAiQLYEPNP
OrthoDBiEOG091G0CPG
TreeFamiTF319356

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRSiSparcl1 mouse
PROiPR:P70663
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029309 Expressed in 278 organ(s), highest expression level in superior colliculus
CleanExiMM_SPARCL1
ExpressionAtlasiP70663 baseline and differential
GenevisibleiP70663 MM

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR003645 Fol_N
IPR015369 Follistatin/Osteonectin_EGF
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR001999 Osteonectin_CS
IPR037641 SPARC
IPR016359 SPARC-like_p1
IPR019577 SPARC/Testican_Ca-bd-dom
PANTHERiPTHR13866 PTHR13866, 1 hit
PfamiView protein in Pfam
PF09289 FOLN, 1 hit
PF00050 Kazal_1, 1 hit
PF10591 SPARC_Ca_bdg, 1 hit
PIRSFiPIRSF002574 SPARC-like_p1, 1 hit
SMARTiView protein in SMART
SM00274 FOLN, 1 hit
SM00280 KAZAL, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS51465 KAZAL_2, 1 hit
PS00612 OSTEONECTIN_1, 1 hit
PS00613 OSTEONECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPRL1_MOUSE
AccessioniPrimary (citable) accession number: P70663
Secondary accession number(s): E9QPH2, P97810, Q99L82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 150 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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