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Protein

Neurogenin-3

Gene

Neurog3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenin-3
Short name:
NGN-3
Alternative name(s):
Helix-loop-helix protein mATH-4B
Short name:
mATH4B
Protein atonal homolog 5
Gene namesi
Name:Neurog3
Synonyms:Ath4b, Atoh5, Ngn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:893591 Neurog3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001274031 – 214Neurogenin-3Add BLAST214

Proteomic databases

PaxDbiP70661
PRIDEiP70661

PTM databases

iPTMnetiP70661
PhosphoSitePlusiP70661

Expressioni

Gene expression databases

BgeeiENSMUSG00000044312 Expressed in 62 organ(s), highest expression level in pancreas
CleanExiMM_NEUROG3
ExpressionAtlasiP70661 baseline and differential
GenevisibleiP70661 MM

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Interacts with ATOH8.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054054

Structurei

3D structure databases

ProteinModelPortaliP70661
SMRiP70661
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 135bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiKOG3898 Eukaryota
ENOG4111U26 LUCA
GeneTreeiENSGT00680000099860
HOGENOMiHOG000063655
HOVERGENiHBG031743
InParanoidiP70661
KOiK08028
OMAiADHSFYG
OrthoDBiEOG091G0PNH
PhylomeDBiP70661
TreeFamiTF315153

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR032656 Ngn3
PANTHERiPTHR19290:SF94 PTHR19290:SF94, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P70661-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPHPLDALT IQVSPETQQP FPGASDHEVL SSNSTPPSPT LIPRDCSEAE
60 70 80 90 100
VGDCRGTSRK LRARRGGRNR PKSELALSKQ RRSRRKKAND RERNRMHNLN
110 120 130 140 150
SALDALRGVL PTFPDDAKLT KIETLRFAHN YIWALTQTLR IADHSFYGPE
160 170 180 190 200
PPVPCGELGS PGGGSNGDWG SIYSPVSQAG NLSPTASLEE FPGLQVPSSP
210
SYLLPGALVF SDFL
Length:214
Mass (Da):23,267
Last modified:February 1, 1997 - v1
Checksum:i1AB31183291FB98B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P770A0A1W2P770_MOUSE
Neurogenin-3
Neurog3
50Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09167 Genomic DNA Translation: CAA70366.1
U76208 Genomic DNA Translation: AAC53029.1
CCDSiCCDS23887.1
RefSeqiNP_033849.3, NM_009719.6
UniGeneiMm.57236

Genome annotation databases

EnsembliENSMUST00000050103; ENSMUSP00000054054; ENSMUSG00000044312
GeneIDi11925
KEGGimmu:11925
UCSCiuc007fgu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09167 Genomic DNA Translation: CAA70366.1
U76208 Genomic DNA Translation: AAC53029.1
CCDSiCCDS23887.1
RefSeqiNP_033849.3, NM_009719.6
UniGeneiMm.57236

3D structure databases

ProteinModelPortaliP70661
SMRiP70661
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054054

PTM databases

iPTMnetiP70661
PhosphoSitePlusiP70661

Proteomic databases

PaxDbiP70661
PRIDEiP70661

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050103; ENSMUSP00000054054; ENSMUSG00000044312
GeneIDi11925
KEGGimmu:11925
UCSCiuc007fgu.1 mouse

Organism-specific databases

CTDi50674
MGIiMGI:893591 Neurog3

Phylogenomic databases

eggNOGiKOG3898 Eukaryota
ENOG4111U26 LUCA
GeneTreeiENSGT00680000099860
HOGENOMiHOG000063655
HOVERGENiHBG031743
InParanoidiP70661
KOiK08028
OMAiADHSFYG
OrthoDBiEOG091G0PNH
PhylomeDBiP70661
TreeFamiTF315153

Miscellaneous databases

PROiPR:P70661
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044312 Expressed in 62 organ(s), highest expression level in pancreas
CleanExiMM_NEUROG3
ExpressionAtlasiP70661 baseline and differential
GenevisibleiP70661 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR032656 Ngn3
PANTHERiPTHR19290:SF94 PTHR19290:SF94, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNGN3_MOUSE
AccessioniPrimary (citable) accession number: P70661
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: November 7, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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