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UniProtKB - P70623 (FABP4_RAT)
Protein
Fatty acid-binding protein, adipocyte
Gene
Fabp4
Organism
Rattus norvegicus (Rat)
Status
Functioni
Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.
By similarityGO - Molecular functioni
- fatty acid binding Source: GO_Central
- hormone receptor binding Source: RGD
- long-chain fatty acid binding Source: UniProtKB
- long-chain fatty acid transporter activity Source: UniProtKB
GO - Biological processi
- brown fat cell differentiation Source: RGD
- cellular response to lithium ion Source: RGD
- cellular response to tumor necrosis factor Source: RGD
- cholesterol homeostasis Source: RGD
- fatty acid metabolic process Source: RGD
- fatty acid transport Source: GO_Central
- long-chain fatty acid transport Source: UniProtKB
- negative regulation of protein kinase activity Source: RGD
- negative regulation of transcription, DNA-templated Source: RGD
- positive regulation of cell population proliferation Source: RGD
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of inflammatory response Source: RGD
- response to bacterium Source: RGD
- response to glucocorticoid Source: RGD
- response to xenobiotic stimulus Source: RGD
- white fat cell differentiation Source: RGD
Keywordsi
Biological process | Transport |
Ligand | Lipid-binding |
Enzyme and pathway databases
Reactomei | R-RNO-163560, Triglyceride catabolism |
Names & Taxonomyi
Protein namesi | Recommended name: Fatty acid-binding protein, adipocyteAlternative name(s): Adipocyte lipid-binding protein Short name: ALBP Adipocyte-type fatty acid-binding protein Short name: A-FABP Short name: AFABP Fatty acid-binding protein 4 |
Gene namesi | Name:Fabp4 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 69309, Fabp4 |
Subcellular locationi
Cytosol
- cytosol Source: RGD
Nucleus
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: RGD
- lipid droplet Source: Reactome
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000067369 | 2 – 132 | Fatty acid-binding protein, adipocyteAdd BLAST | 131 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylcysteineBy similarity | 1 | |
Modified residuei | 13 | PhosphoserineCombined sources | 1 | |
Modified residuei | 20 | Phosphotyrosine; by Tyr-kinasesBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PaxDbi | P70623 |
PRIDEi | P70623 |
PTM databases
iPTMneti | P70623 |
PhosphoSitePlusi | P70623 |
Interactioni
Subunit structurei
Monomer (By similarity). Homodimer.
Interacts with PPARG (By similarity).
By similarityGO - Molecular functioni
- hormone receptor binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000014701 |
Chemistry databases
BindingDBi | P70623 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 127 – 129 | Fatty acid bindingBy similarity | 3 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 22 – 32 | Nuclear localization signalBy similarityAdd BLAST | 11 |
Domaini
Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.By similarity
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4015, Eukaryota |
InParanoidi | P70623 |
PhylomeDBi | P70623 |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR012674, Calycin IPR033073, FABP4 IPR000463, Fatty_acid-bd IPR031259, ILBP IPR000566, Lipocln_cytosolic_FA-bd_dom |
PANTHERi | PTHR11955, PTHR11955, 1 hit PTHR11955:SF83, PTHR11955:SF83, 1 hit |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
PRINTSi | PR00178, FATTYACIDBP |
SUPFAMi | SSF50814, SSF50814, 1 hit |
PROSITEi | View protein in PROSITE PS00214, FABP, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P70623-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCDAFVGTWK LVSSENFDDY MKEVGVGFAT RKVAGMAKPN LIISVEGDLV
60 70 80 90 100
VIRSESTFKN TEISFKLGVE FDEITPDDRK VKSIITLDGG VLVHVQKWDG
110 120 130
KSTTIKKRRD GDKLVVECVM KGVTSTRVYE RA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5XFV4 | Q5XFV4_RAT | Fatty acid-binding protein, adipocy... | Fabp4 rCG_41639 | 132 | Annotation score: | ||
A0A8I5Y7N0 | A0A8I5Y7N0_RAT | Fatty acid-binding protein, adipocy... | Fabp4 | 142 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U75581 mRNA Translation: AAB18344.1 |
Genome annotation databases
UCSCi | RGD:69309, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U75581 mRNA Translation: AAB18344.1 |
3D structure databases
AlphaFoldDBi | P70623 |
SMRi | P70623 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000014701 |
Chemistry databases
BindingDBi | P70623 |
ChEMBLi | CHEMBL2021755 |
PTM databases
iPTMneti | P70623 |
PhosphoSitePlusi | P70623 |
Proteomic databases
PaxDbi | P70623 |
PRIDEi | P70623 |
Genome annotation databases
UCSCi | RGD:69309, rat |
Organism-specific databases
RGDi | 69309, Fabp4 |
Phylogenomic databases
eggNOGi | KOG4015, Eukaryota |
InParanoidi | P70623 |
PhylomeDBi | P70623 |
Enzyme and pathway databases
Reactomei | R-RNO-163560, Triglyceride catabolism |
Miscellaneous databases
PROi | PR:P70623 |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR012674, Calycin IPR033073, FABP4 IPR000463, Fatty_acid-bd IPR031259, ILBP IPR000566, Lipocln_cytosolic_FA-bd_dom |
PANTHERi | PTHR11955, PTHR11955, 1 hit PTHR11955:SF83, PTHR11955:SF83, 1 hit |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
PRINTSi | PR00178, FATTYACIDBP |
SUPFAMi | SSF50814, SSF50814, 1 hit |
PROSITEi | View protein in PROSITE PS00214, FABP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FABP4_RAT | |
Accessioni | P70623Primary (citable) accession number: P70623 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 137 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families