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Entry version 140 (07 Oct 2020)
Sequence version 2 (01 Nov 1998)
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Protein

Small conductance calcium-activated potassium channel protein 1

Gene

Kcnn1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Ion channel
Biological processIon transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-1296052, Ca2+ activated K+ channels

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Small conductance calcium-activated potassium channel protein 1
Short name:
SK1
Short name:
SKCa 1
Short name:
SKCa1
Alternative name(s):
KCa2.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Kcnn1
Synonyms:Sk1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Rat genome database

More...
RGDi
2962, Kcnn1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei107 – 127Helical; Name=Segment S1Sequence analysisAdd BLAST21
Transmembranei136 – 156Helical; Name=Segment S2Sequence analysisAdd BLAST21
Transmembranei224 – 244Helical; Name=Segment S3Sequence analysisAdd BLAST21
Transmembranei273 – 293Helical; Name=Segment S4Sequence analysisAdd BLAST21
Transmembranei313 – 333Helical; Name=Segment S5Sequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei342 – 362Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Transmembranei487 – 507Helical; Name=Segment S6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3743

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001550091 – 536Small conductance calcium-activated potassium channel protein 1Add BLAST536

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P70606

PRoteomics IDEntifications database

More...
PRIDEi
P70606

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P70606

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P70606

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed including brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000029264, Expressed in frontal cortex and 21 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P70606, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P70606, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P70606, 1 interactor

Molecular INTeraction database

More...
MINTi
P70606

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000042517

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P70606

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P70606

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni380 – 459Calmodulin-bindingBy similarityAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi66 – 74Poly-Glu9

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3684, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182904

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P70606

KEGG Orthology (KO)

More...
KOi
K04942

Identification of Orthologs from Complete Genome Data

More...
OMAi
PLFAIKC

Database of Orthologous Groups

More...
OrthoDBi
907751at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P70606

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004178, CaM-bd_dom
IPR036122, CaM-bd_dom_sf
IPR015449, K_chnl_Ca-activ_SK
IPR013099, K_chnl_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10153, PTHR10153, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02888, CaMBD, 1 hit
PF07885, Ion_trans_2, 1 hit
PF03530, SK_channel, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01451, SKCHANNEL

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01053, CaMBD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81327, SSF81327, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P70606-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSRSHNGSV GRPLGSGPGF LGWEPVDPEA GRPRQPTQGP GLQMMAKGQP
60 70 80 90 100
AGLSPSGPRG HSQAQEEEEE EEDEDRPGSG KPPTVSHRLG HRRALFEKRK
110 120 130 140 150
RLSDYALIFG MFGIVVMVTE TELSWGVYTK ESLCSFALKC LISLSTVILL
160 170 180 190 200
GLVILYHARE IQLFLVDNGA DDWRIAMTWE RVSLISLELA VCAIHPVPGH
210 220 230 240 250
YRFTWTARLA FSLVPSAAEA DVDVLLSIPM FLRLYLLARV MLLHSRIFTD
260 270 280 290 300
ASSRSIGALN RVTFNTRFVT KTLMTICPGT VLLVFSISSW IVAAWTVRVC
310 320 330 340 350
ERYHDKQEVT SNFLGAMWLI SITFLSIGYG DMVPHTYCGK GVCLLTGIMG
360 370 380 390 400
AGCTALVVAV VARKLELTKA EKHVHNFMMD TQLTKRVKNA AANVLRETWL
410 420 430 440 450
IYKHTRLVKK PDQSRVRKHQ RKFLQAIHQA QKLRTVKIEQ GKVNDQANTL
460 470 480 490 500
ADLAKAQSIA YEVVSELQAQ QEELEARLAA LESRLDVLGA SLQALPSLIA
510 520 530
QAICPLPPPW PGPSHLTTAA QSPQSHWLPT TASDCG
Length:536
Mass (Da):59,215
Last modified:November 1, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i97FF82071B0BE36A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2K6L7A0A0G2K6L7_RAT
Small conductance calcium-activated...
Kcnn1
533Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF000973 mRNA Translation: AAB82740.1
U69885 mRNA Translation: AAB09564.1

NCBI Reference Sequences

More...
RefSeqi
NP_062186.1, NM_019313.1
XP_017455721.1, XM_017600232.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000044291; ENSRNOP00000042517; ENSRNOG00000029264

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54261

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:54261

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000973 mRNA Translation: AAB82740.1
U69885 mRNA Translation: AAB09564.1
RefSeqiNP_062186.1, NM_019313.1
XP_017455721.1, XM_017600232.1

3D structure databases

SMRiP70606
ModBaseiSearch...

Protein-protein interaction databases

IntActiP70606, 1 interactor
MINTiP70606
STRINGi10116.ENSRNOP00000042517

Chemistry databases

BindingDBiP70606
ChEMBLiCHEMBL3743

PTM databases

iPTMnetiP70606
PhosphoSitePlusiP70606

Proteomic databases

PaxDbiP70606
PRIDEiP70606

Genome annotation databases

EnsembliENSRNOT00000044291; ENSRNOP00000042517; ENSRNOG00000029264
GeneIDi54261
KEGGirno:54261

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3780
RGDi2962, Kcnn1

Phylogenomic databases

eggNOGiKOG3684, Eukaryota
GeneTreeiENSGT00950000182904
InParanoidiP70606
KOiK04942
OMAiPLFAIKC
OrthoDBi907751at2759
PhylomeDBiP70606

Enzyme and pathway databases

ReactomeiR-RNO-1296052, Ca2+ activated K+ channels

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P70606

Gene expression databases

BgeeiENSRNOG00000029264, Expressed in frontal cortex and 21 other tissues
ExpressionAtlasiP70606, baseline and differential
GenevisibleiP70606, RN

Family and domain databases

InterProiView protein in InterPro
IPR004178, CaM-bd_dom
IPR036122, CaM-bd_dom_sf
IPR015449, K_chnl_Ca-activ_SK
IPR013099, K_chnl_dom
PANTHERiPTHR10153, PTHR10153, 1 hit
PfamiView protein in Pfam
PF02888, CaMBD, 1 hit
PF07885, Ion_trans_2, 1 hit
PF03530, SK_channel, 1 hit
PRINTSiPR01451, SKCHANNEL
SMARTiView protein in SMART
SM01053, CaMBD, 1 hit
SUPFAMiSSF81327, SSF81327, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCNN1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P70606
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 1, 1998
Last modified: October 7, 2020
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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