UniProtKB - P70605 (KCNN3_RAT)
Protein
Small conductance calcium-activated potassium channel protein 3
Gene
Kcnn3
Organism
Rattus norvegicus (Rat)
Status
Functioni
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
GO - Molecular functioni
- calmodulin binding Source: RGD
- protein-containing complex binding Source: RGD
- small conductance calcium-activated potassium channel activity Source: RGD
GO - Biological processi
- ion transport Source: GO_Central
- potassium ion transmembrane transport Source: GO_Central
- potassium ion transport Source: RGD
Keywordsi
Molecular function | Calmodulin-binding, Ion channel |
Biological process | Ion transport, Transport |
Enzyme and pathway databases
Reactomei | R-RNO-1296052, Ca2+ activated K+ channels |
Names & Taxonomyi
Protein namesi | Recommended name: Small conductance calcium-activated potassium channel protein 3Short name: SK3 Short name: SKCa 3 Short name: SKCa3 Alternative name(s): KCa2.3 |
Gene namesi | Name:Kcnn3 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2964, Kcnn3 |
Subcellular locationi
Other locations
Plasma Membrane
- plasma membrane Source: RGD
Other locations
- cell body Source: RGD
- cytoplasm Source: RGD
- filopodium Source: RGD
- integral component of membrane Source: UniProtKB-KW
- neuromuscular junction Source: RGD
- neuron projection Source: RGD
- neuronal cell body Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 289 – 309 | Helical; Name=Segment S1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 316 – 336 | Helical; Name=Segment S2Sequence analysisAdd BLAST | 21 | |
Transmembranei | 367 – 387 | Helical; Name=Segment S3Sequence analysisAdd BLAST | 21 | |
Transmembranei | 406 – 426 | Helical; Name=Segment S4Sequence analysisAdd BLAST | 21 | |
Transmembranei | 455 – 475 | Helical; Name=Segment S5Sequence analysisAdd BLAST | 21 | |
Intramembranei | 495 – 515 | Pore-forming; Name=Segment H5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 524 – 544 | Helical; Name=Segment S6Sequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL3780 |
DrugCentrali | P70605 |
GuidetoPHARMACOLOGYi | 383 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000155016 | 1 – 732 | Small conductance calcium-activated potassium channel protein 3Add BLAST | 732 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 168 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P70605 |
PRIDEi | P70605 |
PTM databases
PhosphoSitePlusi | P70605 |
Interactioni
Subunit structurei
Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).
Interacts with CALM1 (By similarity).
By similarityGO - Molecular functioni
- calmodulin binding Source: RGD
Protein-protein interaction databases
IntActi | P70605, 1 interactor |
STRINGi | 10116.ENSRNOP00000028117 |
Chemistry databases
BindingDBi | P70605 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 562 – 638 | Calmodulin-bindingBy similarityAdd BLAST | 77 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 19 – 59 | Pro-richAdd BLAST | 41 | |
Compositional biasi | 30 – 95 | Gln-richAdd BLAST | 66 | |
Compositional biasi | 684 – 688 | Poly-Gln | 5 | |
Compositional biasi | 728 – 731 | Poly-Ser | 4 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3684, Eukaryota |
InParanoidi | P70605 |
OrthoDBi | 907751at2759 |
PhylomeDBi | P70605 |
Family and domain databases
InterProi | View protein in InterPro IPR004178, CaM-bd_dom IPR036122, CaM-bd_dom_sf IPR015449, K_chnl_Ca-activ_SK IPR013099, K_chnl_dom |
PANTHERi | PTHR10153, PTHR10153, 1 hit |
Pfami | View protein in Pfam PF02888, CaMBD, 1 hit PF07885, Ion_trans_2, 1 hit PF03530, SK_channel, 1 hit |
PRINTSi | PR01451, SKCHANNEL |
SMARTi | View protein in SMART SM01053, CaMBD, 1 hit |
SUPFAMi | SSF81327, SSF81327, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P70605-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDTSGHFHDS GVGDLDEDPK CPCPSSGDEQ QQQQQPPPPS APPAVPQQPP
60 70 80 90 100
GPLLQPQPPQ LQQQQQQQQQ QQQQQQQQQQ APLHPLPQLA QLQSQLVHPG
110 120 130 140 150
LLHSSPTAFR APNSANSTAI LHPSSRQGSQ LNLNDHLLGH SPSSTATSGP
160 170 180 190 200
GGGSRHRQAS PLVHRRDSNP FTEIAMSSCK YSGGVMKPLS RLSASRRNLI
210 220 230 240 250
EAEPEGQPLQ LFSPSNPPEI IISSREDNHA HQTLLHHPNA THNHQHAGTT
260 270 280 290 300
AGSTTFPKAN KRKNQNIGYK LGHRRALFEK RKRLSDYALI FGMFGIVVMV
310 320 330 340 350
IETELSWGLY SKDSMFSLAL KCLISLSTII LLGLIIAYHT REVQLFVIDN
360 370 380 390 400
GADDWRIAMT YERILYISLE MLVCAIHPIP GEYKFFWTAR LAFSYTPSRA
410 420 430 440 450
EADVDIILSI PMFLRLYLIA RVMLLHSKLF TDASSRSIGA LNKINFNTRF
460 470 480 490 500
VMKTLMTICP GTVLLVFSIS LWIIAAWTVR VCERYHDQQD VTSNFLGAMW
510 520 530 540 550
LISITFLSIG YGDMVPHTYC GKGVCLLTGI MGAGCTALVV AVVARKLELT
560 570 580 590 600
KAEKHVHNFM MDTQLTKRIK NAAANVLRET WLIYKHTKLL KKIDHAKVRK
610 620 630 640 650
HQRKFLQAIH QLRGVKMEQR KLSDQANTLV DLSKMQNVMY DLITELNDRS
660 670 680 690 700
EDLEKQIGSL ESKLEHLTAS FNSLPLLIAD TLRQQQQQLL TAFVEARGIS
710 720 730
VAVGTSHAPP SDSPIGISST SFPTPYTSSS SC
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V8S7 | G3V8S7_RAT | Potassium intermediate/small conduc... | Kcnn3 rCG_62604 | 731 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 9 | D → E in AAB81653 (PubMed:8781233).Curated | 1 | |
Sequence conflicti | 96 | L → V in AAB81653 (PubMed:8781233).Curated | 1 | |
Sequence conflicti | 138 | L → V in AAB81653 (PubMed:8781233).Curated | 1 | |
Sequence conflicti | 162 | L → V in AAB81653 (PubMed:8781233).Curated | 1 | |
Sequence conflicti | 190 | S → N in AAB81653 (PubMed:8781233).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 78 – 79 | Missing 1 Publication | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U69884 mRNA Translation: AAB81653.1 AF292389 mRNA Translation: AAG13967.1 AF284345 mRNA Translation: AAG38878.1 |
RefSeqi | NP_062188.2, NM_019315.2 |
Genome annotation databases
GeneIDi | 54263 |
KEGGi | rno:54263 |
UCSCi | RGD:2964, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U69884 mRNA Translation: AAB81653.1 AF292389 mRNA Translation: AAG13967.1 AF284345 mRNA Translation: AAG38878.1 |
RefSeqi | NP_062188.2, NM_019315.2 |
3D structure databases
SMRi | P70605 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P70605, 1 interactor |
STRINGi | 10116.ENSRNOP00000028117 |
Chemistry databases
BindingDBi | P70605 |
ChEMBLi | CHEMBL3780 |
DrugCentrali | P70605 |
GuidetoPHARMACOLOGYi | 383 |
PTM databases
PhosphoSitePlusi | P70605 |
Proteomic databases
PaxDbi | P70605 |
PRIDEi | P70605 |
Genome annotation databases
GeneIDi | 54263 |
KEGGi | rno:54263 |
UCSCi | RGD:2964, rat |
Organism-specific databases
CTDi | 3782 |
RGDi | 2964, Kcnn3 |
Phylogenomic databases
eggNOGi | KOG3684, Eukaryota |
InParanoidi | P70605 |
OrthoDBi | 907751at2759 |
PhylomeDBi | P70605 |
Enzyme and pathway databases
Reactomei | R-RNO-1296052, Ca2+ activated K+ channels |
Miscellaneous databases
PROi | PR:P70605 |
Family and domain databases
InterProi | View protein in InterPro IPR004178, CaM-bd_dom IPR036122, CaM-bd_dom_sf IPR015449, K_chnl_Ca-activ_SK IPR013099, K_chnl_dom |
PANTHERi | PTHR10153, PTHR10153, 1 hit |
Pfami | View protein in Pfam PF02888, CaMBD, 1 hit PF07885, Ion_trans_2, 1 hit PF03530, SK_channel, 1 hit |
PRINTSi | PR01451, SKCHANNEL |
SMARTi | View protein in SMART SM01053, CaMBD, 1 hit |
SUPFAMi | SSF81327, SSF81327, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KCNN3_RAT | |
Accessioni | P70605Primary (citable) accession number: P70605 Secondary accession number(s): Q9EQ81, Q9ERQ4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 |
Last sequence update: | November 16, 2001 | |
Last modified: | February 10, 2021 | |
This is version 144 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families