Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Prostaglandin E2 receptor EP1 subtype

Gene

Ptger1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function (By similarity). Implicated the smooth muscle contractile response to PGE2 in various tissues. Isoform 1 and isoform 2 have identical ligand binding properties, but isoform 2 lacks coupling to calcium mobilization and may therefore attenuate the action of PGE2 on tissues.By similarity

GO - Molecular functioni

  • D1 dopamine receptor binding Source: Ensembl
  • prostaglandin E receptor activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-391908 Prostanoid ligand receptors
R-RNO-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin E2 receptor EP1 subtype
Short name:
PGE receptor EP1 subtype
Short name:
PGE2 receptor EP1 subtype
Alternative name(s):
Prostanoid EP1 receptor
Gene namesi
Name:Ptger1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi3434 Ptger1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
Transmembranei40 – 62Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini63 – 80CytoplasmicSequence analysisAdd BLAST18
Transmembranei81 – 99Helical; Name=2Sequence analysisAdd BLAST19
Topological domaini100 – 113ExtracellularSequence analysisAdd BLAST14
Transmembranei114 – 135Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini136 – 157CytoplasmicSequence analysisAdd BLAST22
Transmembranei158 – 179Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini180 – 202ExtracellularSequence analysisAdd BLAST23
Transmembranei203 – 228Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini229 – 301CytoplasmicSequence analysisAdd BLAST73
Transmembranei302 – 323Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini324 – 337ExtracellularSequence analysisAdd BLAST14
Transmembranei338 – 357Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini358 – 405CytoplasmicSequence analysisAdd BLAST48

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5068
GuidetoPHARMACOLOGYi340

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700521 – 405Prostaglandin E2 receptor EP1 subtypeAdd BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi112 ↔ 190PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated.Curated

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP70597
PRIDEiP70597

PTM databases

PhosphoSitePlusiP70597

Expressioni

Tissue specificityi

Highly abundant in kidney and lung. Found in a lesser extent in spleen, colon, and thymus. Also expressed in uterine myometrium and endometrium.

Gene expression databases

BgeeiENSRNOG00000004094
GenevisibleiP70597 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi247666, 1 interactor
STRINGi10116.ENSRNOP00000005470

Chemistry databases

BindingDBiP70597

Structurei

3D structure databases

ProteinModelPortaliP70597
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119188
HOGENOMiHOG000015238
HOVERGENiHBG003621
InParanoidiP70597
KOiK04258
OMAiCICWSPM
OrthoDBiEOG091G0NMF
PhylomeDBiP70597
TreeFamiTF324982

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR008365 Prostanoid_rcpt
IPR001244 Prostglndn_DP_rcpt
IPR000708 Prostglndn_EP1_rcpt
PANTHERiPTHR11866 PTHR11866, 1 hit
PTHR11866:SF3 PTHR11866:SF3, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00428 PROSTAGLNDNR
PR01788 PROSTANOIDR
PR00580 PRSTNOIDEP1R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P70597-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPYGLNLSL VDEATTCVTP RVPNTSVVLP TGGNGTSPAL PIFSMTLGAV
60 70 80 90 100
SNVLALALLA QVAGRLRRRR STATFLLFVA SLLAIDLAGH VIPGALVLRL
110 120 130 140 150
YTAGRAPAGG ACHFLGGCMV FFGLCPLLLG CGMAVERCVG VTQPLIHAAR
160 170 180 190 200
VSVARARLAL ALLAAMALAV ALLPLVHVGH YELQYPGTWC FISLGPPGGW
210 220 230 240 250
RQALLAGLFA GLGLAALLAA LVCNTLSGLA LLRARWRRRR SRRFRENAGP
260 270 280 290 300
DDRRRWGSRG LRLASASSAS SITSTTAALR SSRGGGSARR VHAHDVEMVG
310 320 330 340 350
QLVGIMVVSC ICWSPLLVLV VLAIGGWNSN SLQRPLFLAV RLASWNQILD
360 370 380 390 400
PWVYILLRQA MLRQLLRLLP LRVSAKGGPT ELSLTKSAWE ASSLRSSRHS

GFSHL
Length:405
Mass (Da):43,048
Last modified:February 1, 1997 - v1
Checksum:iE8312388B619F9EC
GO
Isoform 2 (identifier: P70597-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     319-366: LVVLAIGGWN...LRQAMLRQLL → RGAVAPQAKL...FFTLFGNLCK
     367-405: Missing.

Show »
Length:366
Mass (Da):38,498
Checksum:i82ADD2DCB12EB5C0
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001927319 – 366LVVLA…LRQLL → RGAVAPQAKLFSAPSWPLPA KDPACRQKPAPLLSRTLTFF TLFGNLCK in isoform 2. CuratedAdd BLAST48
Alternative sequenceiVSP_001928367 – 405Missing in isoform 2. CuratedAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68037 mRNA Translation: AAB07735.1
D88751 mRNA Translation: BAA13691.1
D88752 mRNA Translation: BAA13692.1
RefSeqiNP_001265404.1, NM_001278475.1 [P70597-1]
UniGeneiRn.11423

Genome annotation databases

EnsembliENSRNOT00000005470; ENSRNOP00000005470; ENSRNOG00000004094 [P70597-1]
GeneIDi25637
KEGGirno:25637

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPE2R1_RAT
AccessioniPrimary (citable) accession number: P70597
Secondary accession number(s): P97537
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: July 18, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health